BRD-A19500257_geldanamycin_MCF10A_3_h_0.12_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

235 genes differentially expressed following the BRD-A19500257_geldanamycin_MCF10A_3_h_0.12_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANXA10 annexin A10
ANXA3 annexin A3
ARMCX3 armadillo repeat containing, X-linked 3
ARMCX6 armadillo repeat containing, X-linked 6
BAG3 BCL2-associated athanogene 3
BEX1 brain expressed, X-linked 1
CACYBP calcyclin binding protein
CAPN6 calpain 6
CD83 CD83 molecule
CDC42 cell division cycle 42
CDK2AP2 cyclin-dependent kinase 2 associated protein 2
CHI3L2 chitinase 3-like 2
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CLEC2B C-type lectin domain family 2, member B
COL5A2 collagen, type V, alpha 2
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRELD2 cysteine-rich with EGF-like domains 2
CXCL5 chemokine (C-X-C motif) ligand 5
CYTIP cytohesin 1 interacting protein
DDIT3 DNA-damage-inducible transcript 3
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EXOSC4 exosome component 4
FKBP11 FK506 binding protein 11, 19 kDa
FOLR1 folate receptor 1 (adult)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA4L heat shock 70kDa protein 4-like
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IFI6 interferon, alpha-inducible protein 6
IGHD immunoglobulin heavy constant delta
IGHMBP2 immunoglobulin mu binding protein 2
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV3-20 immunoglobulin kappa variable 3-20
IGKV4-1 immunoglobulin kappa variable 4-1
JCHAIN joining chain of multimeric IgA and IgM
JMJD6 jumonji domain containing 6
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
LAMP3 lysosomal-associated membrane protein 3
LAPTM4B lysosomal protein transmembrane 4 beta
LIMCH1 LIM and calponin homology domains 1
MANF mesencephalic astrocyte-derived neurotrophic factor
MAOB monoamine oxidase B
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MARCKS myristoylated alanine-rich protein kinase C substrate
MATN2 matrilin 2
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP12 matrix metallopeptidase 12
MT1E metallothionein 1E
NELL2 NEL-like 2 (chicken)
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NRBF2 nuclear receptor binding factor 2
OLFM1 olfactomedin 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBX1 pre-B-cell leukemia homeobox 1
PDZD2 PDZ domain containing 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PRAME preferentially expressed antigen in melanoma
PTP4A3 protein tyrosine phosphatase type IVA, member 3
QPRT quinolinate phosphoribosyltransferase
RAD9A RAD9 homolog A (S. pombe)
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RPL39L ribosomal protein L39-like
RPS4Y1 ribosomal protein S4, Y-linked 1
RYR1 ryanodine receptor 1 (skeletal)
SCG5 secretogranin V
SDF2L1 stromal cell-derived factor 2-like 1
SEPW1 selenoprotein W, 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SFTPC surfactant protein C
SLPI secretory leukocyte peptidase inhibitor
SPATS2L spermatogenesis associated, serine-rich 2-like
SPEN spen family transcriptional repressor
SPINK1 serine peptidase inhibitor, Kazal type 1
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SSFA2 sperm specific antigen 2
STIP1 stress-induced phosphoprotein 1
TCF4 transcription factor 4
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM45A transmembrane protein 45A
TMEM97 transmembrane protein 97
TNNT1 troponin T type 1 (skeletal, slow)
TRIP6 thyroid hormone receptor interactor 6
TRPS1 trichorhinophalangeal syndrome I
TSPAN13 tetraspanin 13
TSPYL5 TSPY-like 5
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WARS tryptophanyl-tRNA synthetase
WBP5 WW domain binding protein 5
XIST X inactive specific transcript (non-protein coding)
ZC3HAV1 zinc finger CCCH-type, antiviral 1

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIPOQ adiponectin, C1Q and collagen domain containing
ADRB2 adrenoceptor beta 2, surface
AGTR1 angiotensin II receptor, type 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AREG amphiregulin
CA12 carbonic anhydrase XII
CD200 CD200 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDKN2A cyclin-dependent kinase inhibitor 2A
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CFD complement factor D (adipsin)
CHRDL1 chordin-like 1
CNN1 calponin 1, basic, smooth muscle
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CSTA cystatin A (stefin A)
CTGF connective tissue growth factor
CYR61 cysteine-rich, angiogenic inducer, 61
DCLK1 doublecortin-like kinase 1
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DLC1 DLC1 Rho GTPase activating protein
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EPCAM epithelial cell adhesion molecule
ERAP2 endoplasmic reticulum aminopeptidase 2
EREG epiregulin
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
FAM60A family with sequence similarity 60, member A
FAM65B family with sequence similarity 65, member B
FKBP5 FK506 binding protein 5
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
GRB14 growth factor receptor-bound protein 14
GULP1 GULP, engulfment adaptor PTB domain containing 1
H2AFX H2A histone family, member X
HBB hemoglobin, beta
HEATR1 HEAT repeat containing 1
HES1 hes family bHLH transcription factor 1
HMGA2 high mobility group AT-hook 2
IER2 immediate early response 2
IER3 immediate early response 3
IGFBP7 insulin-like growth factor binding protein 7
ISG20 interferon stimulated exonuclease gene 20kDa
ITGA6 integrin, alpha 6
JADE2 jade family PHD finger 2
JAG1 jagged 1
KANK1 KN motif and ankyrin repeat domains 1
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KDM5D lysine (K)-specific demethylase 5D
KLF2 Kruppel-like factor 2
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIF leukemia inhibitory factor
LMOD1 leiomodin 1 (smooth muscle)
LRRC17 leucine rich repeat containing 17
MAB21L2 mab-21-like 2 (C. elegans)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MT1X metallothionein 1X
MT2A metallothionein 2A
MX2 MX dynamin-like GTPase 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYH11 myosin, heavy chain 11, smooth muscle
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NID1 nidogen 1
NOP56 NOP56 ribonucleoprotein
NR4A2 nuclear receptor subfamily 4, group A, member 2
OSBPL10 oxysterol binding protein-like 10
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PCNA proliferating cell nuclear antigen
PDGFA platelet-derived growth factor alpha polypeptide
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAT plasminogen activator, tissue
PLN phospholamban
RGS1 regulator of G-protein signaling 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SORBS2 sorbin and SH3 domain containing 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX11 SRY (sex determining region Y)-box 11
SOX9 SRY (sex determining region Y)-box 9
SPRY4 sprouty homolog 4 (Drosophila)
STC1 stanniocalcin 1
SYNGR1 synaptogyrin 1
TACC2 transforming, acidic coiled-coil containing protein 2
TF transferrin
TFF1 trefoil factor 1
TGIF1 TGFB-induced factor homeobox 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMX4 thioredoxin-related transmembrane protein 4
TNC tenascin C
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TOX3 TOX high mobility group box family member 3
TPSAB1 tryptase alpha/beta 1
TSC22D3 TSC22 domain family, member 3
TSPAN8 tetraspanin 8
TXNIP thioredoxin interacting protein
VCAN versican
WEE1 WEE1 G2 checkpoint kinase
ZFP36 ZFP36 ring finger protein
ZFP36L2 ZFP36 ring finger protein-like 2