BRD-A19500257_geldanamycin_MCF10A_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

198 genes differentially expressed following the BRD-A19500257_geldanamycin_MCF10A_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD6 abhydrolase domain containing 6
AEBP1 AE binding protein 1
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANXA10 annexin A10
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
BAG3 BCL2-associated athanogene 3
BCL6 B-cell CLL/lymphoma 6
BGN biglycan
CACYBP calcyclin binding protein
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CLEC2B C-type lectin domain family 2, member B
CLU clusterin
COL5A2 collagen, type V, alpha 2
COL9A3 collagen, type IX, alpha 3
CPA3 carboxypeptidase A3 (mast cell)
CRYAB crystallin, alpha B
CTSE cathepsin E
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL8 chemokine (C-X-C motif) ligand 8
DLK1 delta-like 1 homolog (Drosophila)
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
ECM1 extracellular matrix protein 1
FGFR3 fibroblast growth factor receptor 3
GJA1 gap junction protein, alpha 1, 43kDa
GRB10 growth factor receptor-bound protein 10
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HOPX HOP homeobox
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IL1RN interleukin 1 receptor antagonist
KRT13 keratin 13, type I
KRT19 keratin 19, type I
KRT7 keratin 7, type II
LIMCH1 LIM and calponin homology domains 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MALT1 MALT1 paracaspase
MAPT microtubule-associated protein tau
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP12 matrix metallopeptidase 12
MSLN mesothelin
NEBL nebulette
NPDC1 neural proliferation, differentiation and control, 1
NPTX2 neuronal pentraxin II
NR2F6 nuclear receptor subfamily 2, group F, member 6
NUPR1 nuclear protein, transcriptional regulator, 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PBX1 pre-B-cell leukemia homeobox 1
PEG3 paternally expressed 3
PEX11A peroxisomal biogenesis factor 11 alpha
PIR pirin (iron-binding nuclear protein)
PODXL podocalyxin-like
PPP1R3C protein phosphatase 1, regulatory subunit 3C
QPRT quinolinate phosphoribosyltransferase
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RGS5 regulator of G-protein signaling 5
RPL27A ribosomal protein L27a
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
S100A7 S100 calcium binding protein A7
SCYL3 SCY1-like 3 (S. cerevisiae)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLPI secretory leukocyte peptidase inhibitor
SPINK1 serine peptidase inhibitor, Kazal type 1
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
STIP1 stress-induced phosphoprotein 1
SYT1 synaptotagmin I
TACSTD2 tumor-associated calcium signal transducer 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBI transforming growth factor, beta-induced, 68kDa
TGM2 transglutaminase 2
TMEM97 transmembrane protein 97
TSPAN13 tetraspanin 13
VWF von Willebrand factor
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADORA2B adenosine A2b receptor
ADRB2 adrenoceptor beta 2, surface
AKAP12 A kinase (PRKA) anchor protein 12
AOX1 aldehyde oxidase 1
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
APOC1 apolipoprotein C-I
APOD apolipoprotein D
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
AREG amphiregulin
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
CA1 carbonic anhydrase I
CCL5 chemokine (C-C motif) ligand 5
CD24 CD24 molecule
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CELF2 CUGBP, Elav-like family member 2
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CLC Charcot-Leyden crystal galectin
CNN3 calponin 3, acidic
CPM carboxypeptidase M
CSTA cystatin A (stefin A)
CTGF connective tissue growth factor
CXCL12 chemokine (C-X-C motif) ligand 12
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DCLK1 doublecortin-like kinase 1
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EGR3 early growth response 3
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPS8 epidermal growth factor receptor pathway substrate 8
EREG epiregulin
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EXOSC4 exosome component 4
F13A1 coagulation factor XIII, A1 polypeptide
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
FAM171A1 family with sequence similarity 171, member A1
FAM60A family with sequence similarity 60, member A
FRY furry homolog (Drosophila)
GDF15 growth differentiation factor 15
GLS glutaminase
GOLM1 golgi membrane protein 1
H1F0 H1 histone family, member 0
HBD hemoglobin, delta
HES1 hes family bHLH transcription factor 1
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
IER3 immediate early response 3
IGFBP6 insulin-like growth factor binding protein 6
KCTD12 potassium channel tetramerization domain containing 12
KDM5D lysine (K)-specific demethylase 5D
LEPR leptin receptor
LTF lactotransferrin
MAN1A1 mannosidase, alpha, class 1A, member 1
MCL1 myeloid cell leukemia 1
MME membrane metallo-endopeptidase
MT1G metallothionein 1G
MT2A metallothionein 2A
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRN1 neuritin 1
NT5E 5'-nucleotidase, ecto (CD73)
PEG10 paternally expressed 10
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
RAB38 RAB38, member RAS oncogene family
RPS4Y1 ribosomal protein S4, Y-linked 1
RRAS2 related RAS viral (r-ras) oncogene homolog 2
S100A9 S100 calcium binding protein A9
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SPP1 secreted phosphoprotein 1
SRSF6 serine/arginine-rich splicing factor 6
STK39 serine threonine kinase 39
SYBU syntabulin (syntaxin-interacting)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
THBS1 thrombospondin 1
THSD7A thrombospondin, type I, domain containing 7A
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKT transketolase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMX4 thioredoxin-related transmembrane protein 4
TNC tenascin C
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TP53I3 tumor protein p53 inducible protein 3
TSPAN7 tetraspanin 7
TUSC3 tumor suppressor candidate 3
TXNIP thioredoxin interacting protein
VCAN versican
WEE1 WEE1 G2 checkpoint kinase
ZBTB18 zinc finger and BTB domain containing 18
ZFP36L2 ZFP36 ring finger protein-like 2