BRD-A19500257_geldanamycin_MCF10A_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

379 genes differentially expressed following the BRD-A19500257_geldanamycin_MCF10A_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ABHD4 abhydrolase domain containing 4
ACKR3 atypical chemokine receptor 3
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADCY9 adenylate cyclase 9
ADIPOQ adiponectin, C1Q and collagen domain containing
AGR2 anterior gradient 2
AKAP9 A kinase (PRKA) anchor protein 9
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANGPTL2 angiopoietin-like 2
APOD apolipoprotein D
AQP1 aquaporin 1 (Colton blood group)
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP9A ATPase, class II, type 9A
ATRX alpha thalassemia/mental retardation syndrome X-linked
BBX bobby sox homolog (Drosophila)
BLNK B-cell linker
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG2 BTG family, member 2
C1ORF54 chromosome 1 open reading frame 54
C1QB complement component 1, q subcomponent, B chain
CA12 carbonic anhydrase XII
CALCOCO1 calcium binding and coiled-coil domain 1
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCL5 chemokine (C-C motif) ligand 5
CCNG2 cyclin G2
CCPG1 cell cycle progression 1
CD14 CD14 molecule
CD163 CD163 molecule
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase
CEP57 centrosomal protein 57kDa
CES1 carboxylesterase 1
CFB complement factor B
CFD complement factor D (adipsin)
CLU clusterin
COL14A1 collagen, type XIV, alpha 1
COL15A1 collagen, type XV, alpha 1
COL1A2 collagen, type I, alpha 2
COL21A1 collagen, type XXI, alpha 1
COL4A5 collagen, type IV, alpha 5
COL6A1 collagen, type VI, alpha 1
COLEC12 collectin sub-family member 12
CPA3 carboxypeptidase A3 (mast cell)
CPE carboxypeptidase E
CRYAB crystallin, alpha B
CST1 cystatin SN
CTSK cathepsin K
CYB5R1 cytochrome b5 reductase 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DCN decorin
DDR1 discoidin domain receptor tyrosine kinase 1
DEFB1 defensin, beta 1
DHCR24 24-dehydrocholesterol reductase
DHRS3 dehydrogenase/reductase (SDR family) member 3
DLG5 discs, large homolog 5 (Drosophila)
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DPT dermatopontin
DSP desmoplakin
DST dystonin
DUSP1 dual specificity phosphatase 1
EFHD1 EF-hand domain family, member D1
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB4 erb-b2 receptor tyrosine kinase 4
F13A1 coagulation factor XIII, A1 polypeptide
FADS2 fatty acid desaturase 2
FAM117A family with sequence similarity 117, member A
FAM8A1 family with sequence similarity 8, member A1
FAXDC2 fatty acid hydroxylase domain containing 2
FBLN1 fibulin 1
FCGBP Fc fragment of IgG binding protein
FOXO4 forkhead box O4
FTH1 ferritin, heavy polypeptide 1
FUCA1 fucosidase, alpha-L- 1, tissue
GABARAPL1 GABA(A) receptor-associated protein like 1
GATA3 GATA binding protein 3
GDF15 growth differentiation factor 15
GLUL glutamate-ammonia ligase
GOLGB1 golgin B1
GPM6B glycoprotein M6B
GPNMB glycoprotein (transmembrane) nmb
GPRC5B G protein-coupled receptor, class C, group 5, member B
GPX3 glutathione peroxidase 3
GSE1 Gse1 coiled-coil protein
GSN gelsolin
GSTM3 glutathione S-transferase mu 3 (brain)
HBB hemoglobin, beta
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HOXA5 homeobox A5
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
IDS iduronate 2-sulfatase
IFITM1 interferon induced transmembrane protein 1
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGSF1 immunoglobulin superfamily, member 1
IL2RB interleukin 2 receptor, beta
IRF9 interferon regulatory factor 9
IRS1 insulin receptor substrate 1
ITM2C integral membrane protein 2C
JAM3 junctional adhesion molecule 3
JUP junction plakoglobin
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KLHL24 kelch-like family member 24
KRT19 keratin 19, type I
KYNU kynureninase
LAMP2 lysosomal-associated membrane protein 2
LCN2 lipocalin 2
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LINC00341 long intergenic non-protein coding RNA 341
LOC100272216 uncharacterized LOC100272216
LTBP1 latent transforming growth factor beta binding protein 1
MAGEA3 melanoma antigen family A3
MAOB monoamine oxidase B
MAP1A microtubule-associated protein 1A
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MATN2 matrilin 2
MDK midkine (neurite growth-promoting factor 2)
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
METTL7A methyltransferase like 7A
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MXRA5 matrix-remodelling associated 5
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
OPTN optineurin
ORAI3 ORAI calcium release-activated calcium modulator 3
OSR2 odd-skipped related transciption factor 2
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFRL platelet-derived growth factor receptor-like
PEG10 paternally expressed 10
PERP PERP, TP53 apoptosis effector
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PINK1 PTEN induced putative kinase 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLIN1 perilipin 1
PLXNB2 plexin B2
PNRC1 proline-rich nuclear receptor coactivator 1
PPAP2B phosphatidic acid phosphatase type 2B
PPL periplakin
PROM1 prominin 1
PRSS23 protease, serine, 23
PTN pleiotrophin
QPRT quinolinate phosphoribosyltransferase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RBP4 retinol binding protein 4, plasma
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
S100A4 S100 calcium binding protein A4
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCUBE2 signal peptide, CUB domain, EGF-like 2
SCYL3 SCY1-like 3 (S. cerevisiae)
SECISBP2L SECIS binding protein 2-like
SELENBP1 selenium binding protein 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPP1 selenoprotein P, plasma, 1
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SGCE sarcoglycan, epsilon
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SPINT1 serine peptidase inhibitor, Kunitz type 1
SQSTM1 sequestosome 1
STC1 stanniocalcin 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
SYNE2 spectrin repeat containing, nuclear envelope 2
SYNM synemin, intermediate filament protein
TBX3 T-box 3
TF transferrin
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR3 transforming growth factor, beta receptor III
TMEM45A transmembrane protein 45A
TRAC T cell receptor alpha constant
TRD T cell receptor delta locus
TRIM22 tripartite motif containing 22
TRIM29 tripartite motif containing 29
TRPS1 trichorhinophalangeal syndrome I
TSKU tsukushi, small leucine rich proteoglycan
TXNIP thioredoxin interacting protein
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
USP9X ubiquitin specific peptidase 9, X-linked
VAV3 vav 3 guanine nucleotide exchange factor
VNN1 vanin 1
VTCN1 V-set domain containing T cell activation inhibitor 1
VWA5A von Willebrand factor A domain containing 5A
WFDC2 WAP four-disulfide core domain 2
WIPI1 WD repeat domain, phosphoinositide interacting 1
WNK1 WNK lysine deficient protein kinase 1
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)
ZNF91 zinc finger protein 91
ZSCAN31 zinc finger and SCAN domain containing 31

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ACTN1 actinin, alpha 1
ADRB2 adrenoceptor beta 2, surface
AK4 adenylate kinase 4
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMD1 adenosylmethionine decarboxylase 1
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ANXA3 annexin A3
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
AURKA aurora kinase A
AXL AXL receptor tyrosine kinase
BIRC5 baculoviral IAP repeat containing 5
BOP1 block of proliferation 1
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C1ORF116 chromosome 1 open reading frame 116
C1QBP complement component 1, q subcomponent binding protein
CALD1 caldesmon 1
CBFB core-binding factor, beta subunit
CCNA2 cyclin A2
CCND1 cyclin D1
CCNF cyclin F
CD3EAP CD3e molecule, epsilon associated protein
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
COTL1 coactosin-like F-actin binding protein 1
CSE1L CSE1 chromosome segregation 1-like (yeast)
CTPS1 CTP synthase 1
CYCS cytochrome c, somatic
CYR61 cysteine-rich, angiogenic inducer, 61
DBF4 DBF4 zinc finger
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DKC1 dyskeratosis congenita 1, dyskerin
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP6 dual specificity phosphatase 6
EDNRB endothelin receptor type B
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF5A eukaryotic translation initiation factor 5A
EMG1 EMG1 N1-specific pseudouridine methyltransferase
EMP1 epithelial membrane protein 1
EMX2 empty spiracles homeobox 2
ENO1 enolase 1, (alpha)
EREG epiregulin
EXOSC2 exosome component 2
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F3 coagulation factor III (thromboplastin, tissue factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FBP1 fructose-1,6-bisphosphatase 1
FEN1 flap structure-specific endonuclease 1
FJX1 four jointed box 1 (Drosophila)
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
GAL galanin/GMAP prepropeptide
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLIPR1 GLI pathogenesis-related 1
GRPEL1 GrpE-like 1, mitochondrial (E. coli)
HMGA2 high mobility group AT-hook 2
HMGB2 high mobility group box 2
HN1 hematological and neurological expressed 1
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
IER2 immediate early response 2
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
ITGA6 integrin, alpha 6
KIAA0020 KIAA0020
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KLK10 kallikrein-related peptidase 10
LBR lamin B receptor
LMNB1 lamin B1
LMNB2 lamin B2
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MALL mal, T-cell differentiation protein-like
MCL1 myeloid cell leukemia 1
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEK2 NIMA-related kinase 2
NET1 neuroepithelial cell transforming 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NOP56 NOP56 ribonucleoprotein
NPM3 nucleophosmin/nucleoplasmin 3
NUP85 nucleoporin 85kDa
NXT1 nuclear transport factor 2-like export factor 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PCNA proliferating cell nuclear antigen
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PFAS phosphoribosylformylglycinamidine synthase
PFKP phosphofructokinase, platelet
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
PNP purine nucleoside phosphorylase
PODXL podocalyxin-like
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR1E polymerase (RNA) I polypeptide E, 53kDa
POLR3G polymerase (RNA) III (DNA directed) polypeptide G (32kD)
PPAT phosphoribosyl pyrophosphate amidotransferase
PRPF4 pre-mRNA processing factor 4
PRPS1 phosphoribosyl pyrophosphate synthetase 1
PRSS2 protease, serine, 2 (trypsin 2)
PSPH phosphoserine phosphatase
PUS7 pseudouridylate synthase 7 (putative)
QDPR quinoid dihydropteridine reductase
RANBP1 RAN binding protein 1
RBM34 RNA binding motif protein 34
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RPS2 ribosomal protein S2
RRM2 ribonucleotide reductase M2
RRP1B ribosomal RNA processing 1B
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A2 S100 calcium binding protein A2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SET SET nuclear proto-oncogene
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLIRP SRA stem-loop interacting RNA binding protein
SNAI2 snail family zinc finger 2
SRI sorcin
SRM spermidine synthase
SRSF3 serine/arginine-rich splicing factor 3
SRSF6 serine/arginine-rich splicing factor 6
SRSF7 serine/arginine-rich splicing factor 7
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TACC3 transforming, acidic coiled-coil containing protein 3
TFDP1 transcription factor Dp-1
TGFBI transforming growth factor, beta-induced, 68kDa
THBS1 thrombospondin 1
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TIPIN TIMELESS interacting protein
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM5 transmembrane protein 5
TNC tenascin C
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRIP13 thyroid hormone receptor interactor 13
TUBA4A tubulin, alpha 4a
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2S ubiquitin-conjugating enzyme E2S
UPP1 uridine phosphorylase 1
VRK1 vaccinia related kinase 1
ZBTB18 zinc finger and BTB domain containing 18
ZDHHC6 zinc finger, DHHC-type containing 6
ZNF22 zinc finger protein 22
ZWINT ZW10 interacting kinetochore protein