BRD-A19500257_geldanamycin_LNCAP_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

80 genes differentially expressed following the BRD-A19500257_geldanamycin_LNCAP_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACBD3 acyl-CoA binding domain containing 3
AMIGO2 adhesion molecule with Ig-like domain 2
BAG3 BCL2-associated athanogene 3
C7 complement component 7
CA2 carbonic anhydrase II
CFD complement factor D (adipsin)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CRELD2 cysteine-rich with EGF-like domains 2
CTSE cathepsin E
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DEFB1 defensin, beta 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
FAM13A family with sequence similarity 13, member A
FAM46C family with sequence similarity 46, member C
FKBP11 FK506 binding protein 11, 19 kDa
GPX3 glutathione peroxidase 3
HBD hemoglobin, delta
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGFBP5 insulin-like growth factor binding protein 5
IGHMBP2 immunoglobulin mu binding protein 2
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
ITM2C integral membrane protein 2C
JCHAIN joining chain of multimeric IgA and IgM
JMJD6 jumonji domain containing 6
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
LYN LYN proto-oncogene, Src family tyrosine kinase
MAL mal, T-cell differentiation protein
MUC5B mucin 5B, oligomeric mucus/gel-forming
MZB1 marginal zone B and B1 cell-specific protein
PDIA4 protein disulfide isomerase family A, member 4
PDIA6 protein disulfide isomerase family A, member 6
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIEZO2 piezo-type mechanosensitive ion channel component 2
POU2AF1 POU class 2 associating factor 1
RAD9A RAD9 homolog A (S. pombe)
RPS11 ribosomal protein S11
SDF2L1 stromal cell-derived factor 2-like 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC35B1 solute carrier family 35, member B1
SLC39A14 solute carrier family 39 (zinc transporter), member 14
TES testin LIM domain protein
TGFA transforming growth factor, alpha
TNFRSF17 tumor necrosis factor receptor superfamily, member 17
TRIB3 tribbles pseudokinase 3
TXNIP thioredoxin interacting protein
WIPI1 WD repeat domain, phosphoinositide interacting 1

decreased expression

Symbol Name
APOD apolipoprotein D
AREG amphiregulin
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
DACH1 dachshund family transcription factor 1
FKBP5 FK506 binding protein 5
GAS1 growth arrest-specific 1
GLUL glutamate-ammonia ligase
GRIA2 glutamate receptor, ionotropic, AMPA 2
IL13RA2 interleukin 13 receptor, alpha 2
JADE2 jade family PHD finger 2
LMO2 LIM domain only 2 (rhombotin-like 1)
MAP7 microtubule-associated protein 7
MCL1 myeloid cell leukemia 1
OXA1L oxidase (cytochrome c) assembly 1-like
PIP prolactin-induced protein
PSPH phosphoserine phosphatase
RTN1 reticulon 1
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
TM4SF1 transmembrane 4 L six family member 1
WEE1 WEE1 G2 checkpoint kinase