BRD-A19500257_geldanamycin_LNCAP_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

299 genes differentially expressed following the BRD-A19500257_geldanamycin_LNCAP_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
AFF1 AF4/FMR2 family, member 1
AKAP13 A kinase (PRKA) anchor protein 13
AMIGO2 adhesion molecule with Ig-like domain 2
ATP2A3 ATPase, Ca++ transporting, ubiquitous
ATRX alpha thalassemia/mental retardation syndrome X-linked
BAMBI BMP and activin membrane-bound inhibitor
BCAM basal cell adhesion molecule (Lutheran blood group)
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
CAB39 calcium binding protein 39
CCNG1 cyclin G1
CCNG2 cyclin G2
CD52 CD52 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD59 CD59 molecule, complement regulatory protein
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
COLEC12 collectin sub-family member 12
CPD carboxypeptidase D
CRABP2 cellular retinoic acid binding protein 2
CTGF connective tissue growth factor
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DENND1B DENN/MADD domain containing 1B
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DSE dermatan sulfate epimerase
ECHDC2 enoyl CoA hydratase domain containing 2
EFNB2 ephrin-B2
EGF epidermal growth factor
ERBB2 erb-b2 receptor tyrosine kinase 2
EZR ezrin
FAM46A family with sequence similarity 46, member A
FGD6 FYVE, RhoGEF and PH domain containing 6
FTH1 ferritin, heavy polypeptide 1
FUCA1 fucosidase, alpha-L- 1, tissue
FXR1 fragile X mental retardation, autosomal homolog 1
GAB2 GRB2-associated binding protein 2
GAS6 growth arrest-specific 6
GATA6 GATA binding protein 6
GLUL glutamate-ammonia ligase
GOLM1 golgi membrane protein 1
GPC3 glypican 3
GRB10 growth factor receptor-bound protein 10
GRN granulin
GUSBP3 glucuronidase, beta pseudogene 3
HIST1H2AC histone cluster 1, H2ac
HIST1H2BG histone cluster 1, H2bg
HIST2H2BE histone cluster 2, H2be
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB1 heat shock 27kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
IDS iduronate 2-sulfatase
IFI27 interferon, alpha-inducible protein 27
JAK1 Janus kinase 1
KDM5B lysine (K)-specific demethylase 5B
KLHL24 kelch-like family member 24
LGALS8 lectin, galactoside-binding, soluble, 8
LOC100272216 uncharacterized LOC100272216
MAGED2 melanoma antigen family D2
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MFAP5 microfibrillar associated protein 5
MSMO1 methylsterol monooxygenase 1
NCOA3 nuclear receptor coactivator 3
NET1 neuroepithelial cell transforming 1
NPC2 Niemann-Pick disease, type C2
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9
OBSL1 obscurin-like 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDGFC platelet derived growth factor C
PDIA3 protein disulfide isomerase family A, member 3
PEG10 paternally expressed 10
PHKA1 phosphorylase kinase, alpha 1 (muscle)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLBD1 phospholipase B domain containing 1
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PRSS8 protease, serine, 8
PXDN peroxidasin
QPRT quinolinate phosphoribosyltransferase
RAB11A RAB11A, member RAS oncogene family
RBPJ recombination signal binding protein for immunoglobulin kappa J region
RGS2 regulator of G-protein signaling 2
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RRAGD Ras-related GTP binding D
RSF1 remodeling and spacing factor 1
RYBP RING1 and YY1 binding protein
SAT1 spermidine/spermine N1-acetyltransferase 1
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPP1 selenoprotein P, plasma, 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SESN1 sestrin 1
SFTPC surfactant protein C
SH3BGRL SH3 domain binding glutamate-rich protein like
SKAP2 src kinase associated phosphoprotein 2
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SNAP23 synaptosomal-associated protein, 23kDa
SORBS3 sorbin and SH3 domain containing 3
SPINT1 serine peptidase inhibitor, Kunitz type 1
SSBP2 single-stranded DNA binding protein 2
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
STAB1 stabilin 1
STC1 stanniocalcin 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
THBS4 thrombospondin 4
TIMP1 TIMP metallopeptidase inhibitor 1
TIMP3 TIMP metallopeptidase inhibitor 3
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM135 transmembrane protein 135
TMEM2 transmembrane protein 2
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TPM4 tropomyosin 4
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UGDH UDP-glucose 6-dehydrogenase
WLS wntless Wnt ligand secretion mediator
XIST X inactive specific transcript (non-protein coding)
YAP1 Yes-associated protein 1
YPEL5 yippee-like 5 (Drosophila)
ZMAT3 zinc finger, matrin-type 3
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
AK4 adenylate kinase 4
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ASF1B anti-silencing function 1B histone chaperone
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
BIRC5 baculoviral IAP repeat containing 5
BOP1 block of proliferation 1
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C1ORF116 chromosome 1 open reading frame 116
C3 complement component 3
CA12 carbonic anhydrase XII
CCDC85B coiled-coil domain containing 85B
CCNA2 cyclin A2
CCNB2 cyclin B2
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDKN3 cyclin-dependent kinase inhibitor 3
CDT1 chromatin licensing and DNA replication factor 1
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CETN3 centrin, EF-hand protein, 3
CHEK2 checkpoint kinase 2
CIT citron rho-interacting serine/threonine kinase
CKB creatine kinase, brain
CXCL14 chemokine (C-X-C motif) ligand 14
CYC1 cytochrome c-1
DACH1 dachshund family transcription factor 1
DBF4 DBF4 zinc finger
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEPDC1 DEP domain containing 1
DHFR dihydrofolate reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ECT2 epithelial cell transforming 2
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EREG epiregulin
EXO1 exonuclease 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAM216A family with sequence similarity 216, member A
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FGFR3 fibroblast growth factor receptor 3
FOXM1 forkhead box M1
GAL galanin/GMAP prepropeptide
GHR growth hormone receptor
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPM6B glycoprotein M6B
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
HAL histidine ammonia-lyase
HBB hemoglobin, beta
HLTF helicase-like transcription factor
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
IGF1R insulin-like growth factor 1 receptor
IGFBP3 insulin-like growth factor binding protein 3
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KIAA0101 KIAA0101
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF4A kinesin family member 4A
KRT17 keratin 17, type I
KRT7 keratin 7, type II
LMNB1 lamin B1
LOC81691 exonuclease NEF-sp
LTF lactotransferrin
LUM lumican
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MPHOSPH9 M-phase phosphoprotein 9
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPD3 non-SMC condensin II complex, subunit D3
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NDC80 NDC80 kinetochore complex component
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NEK2 NIMA-related kinase 2
NNMT nicotinamide N-methyltransferase
NPY1R neuropeptide Y receptor Y1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUSAP1 nucleolar and spindle associated protein 1
OASL 2'-5'-oligoadenylate synthetase-like
OIP5 Opa interacting protein 5
OLFM1 olfactomedin 1
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCNA proliferating cell nuclear antigen
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PFKP phosphofructokinase, platelet
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
PLK4 polo-like kinase 4
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPIF peptidylprolyl isomerase F
PRC1 protein regulator of cytokinesis 1
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PSPH phosphoserine phosphatase
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
PTTG1 pituitary tumor-transforming 1
PUF60 poly-U binding splicing factor 60KDa
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RMI1 RecQ mediated genome instability 1
RNASEH2A ribonuclease H2, subunit A
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SEH1L SEH1-like (S. cerevisiae)
SHCBP1 SHC SH2-domain binding protein 1
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SMC2 structural maintenance of chromosomes 2
SMC4 structural maintenance of chromosomes 4
SORBS2 sorbin and SH3 domain containing 2
SORD sorbitol dehydrogenase
SPC25 SPC25, NDC80 kinetochore complex component
SRM spermidine synthase
STC2 stanniocalcin 2
STEAP3 STEAP family member 3, metalloreductase
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBC1D31 TBC1 domain family, member 31
TESC tescalcin
THEM6 thioesterase superfamily member 6
TIPIN TIMELESS interacting protein
TK1 thymidine kinase 1, soluble
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM194A transmembrane protein 194A
TMEM5 transmembrane protein 5
TMPO thymopoietin
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIB3 tribbles pseudokinase 3
TRIP13 thyroid hormone receptor interactor 13
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UNG uracil-DNA glycosylase
USP1 ubiquitin specific peptidase 1
VRK1 vaccinia related kinase 1
ZWINT ZW10 interacting kinetochore protein