BRD-A19500257_geldanamycin_LNCAP_24_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

251 genes differentially expressed following the BRD-A19500257_geldanamycin_LNCAP_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT1 acetyl-CoA acetyltransferase 1
ACTA2 actin, alpha 2, smooth muscle, aorta
ADGRF5 adhesion G protein-coupled receptor F5
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ALDOB aldolase B, fructose-bisphosphate
AMIGO2 adhesion molecule with Ig-like domain 2
ANPEP alanyl (membrane) aminopeptidase
AREG amphiregulin
ARID5B AT rich interactive domain 5B (MRF1-like)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATRX alpha thalassemia/mental retardation syndrome X-linked
BAG2 BCL2-associated athanogene 2
BEX4 brain expressed, X-linked 4
CAB39 calcium binding protein 39
CADM1 cell adhesion molecule 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCNG1 cyclin G1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CERS2 ceramide synthase 2
CLEC3B C-type lectin domain family 3, member B
COL4A5 collagen, type IV, alpha 5
CPM carboxypeptidase M
CTSC cathepsin C
DEFB1 defensin, beta 1
DNASE1L1 deoxyribonuclease I-like 1
E2F2 E2F transcription factor 2
EFNB2 ephrin-B2
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
FAM13A family with sequence similarity 13, member A
FILIP1L filamin A interacting protein 1-like
FKBP1B FK506 binding protein 1B, 12.6 kDa
G0S2 G0/G1 switch 2
GAS6 growth arrest-specific 6
GLUL glutamate-ammonia ligase
GRB10 growth factor receptor-bound protein 10
GSTM3 glutathione S-transferase mu 3 (brain)
HECA headcase homolog (Drosophila)
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2BC histone cluster 1, H2bc
HIST2H2BE histone cluster 2, H2be
HSPA2 heat shock 70kDa protein 2
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
HTRA1 HtrA serine peptidase 1
IDS iduronate 2-sulfatase
IFI27 interferon, alpha-inducible protein 27
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP7 insulin-like growth factor binding protein 7
IL1R1 interleukin 1 receptor, type I
KDM5B lysine (K)-specific demethylase 5B
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS8 lectin, galactoside-binding, soluble, 8
LOC100272216 uncharacterized LOC100272216
MAOA monoamine oxidase A
MARCH8 membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
MCOLN1 mucolipin 1
MECOM MDS1 and EVI1 complex locus
MYL9 myosin, light chain 9, regulatory
MYO6 myosin VI
NRIP1 nuclear receptor interacting protein 1
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PPAP2A phosphatidic acid phosphatase type 2A
PPP1R3C protein phosphatase 1, regulatory subunit 3C
QPRT quinolinate phosphoribosyltransferase
RAB38 RAB38, member RAS oncogene family
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RRAGD Ras-related GTP binding D
RYBP RING1 and YY1 binding protein
SAT1 spermidine/spermine N1-acetyltransferase 1
SC5D sterol-C5-desaturase
SCPEP1 serine carboxypeptidase 1
SDC2 syndecan 2
SDC4 syndecan 4
SELENBP1 selenium binding protein 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPP1 selenoprotein P, plasma, 1
SESN1 sestrin 1
SKP1 S-phase kinase-associated protein 1
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SPEN spen family transcriptional repressor
SSBP2 single-stranded DNA binding protein 2
STAB1 stabilin 1
TSC22D1 TSC22 domain family, member 1
TSPYL5 TSPY-like 5
TUBA1A tubulin, alpha 1a
UBB ubiquitin B
WISP2 WNT1 inducible signaling pathway protein 2
WLS wntless Wnt ligand secretion mediator
ZNF331 zinc finger protein 331
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
AURKB aurora kinase B
BACE2 beta-site APP-cleaving enzyme 2
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C3 complement component 3
CCNA2 cyclin A2
CCNB2 cyclin B2
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDCA4 cell division cycle associated 4
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDKN3 cyclin-dependent kinase inhibitor 3
CDT1 chromatin licensing and DNA replication factor 1
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CIT citron rho-interacting serine/threonine kinase
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL8 chemokine (C-X-C motif) ligand 8
DACH1 dachshund family transcription factor 1
DBF4 DBF4 zinc finger
DCK deoxycytidine kinase
DHFR dihydrofolate reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ECT2 epithelial cell transforming 2
EXO1 exonuclease 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP7 fatty acid binding protein 7, brain
FANCG Fanconi anemia, complementation group G
FANCI Fanconi anemia, complementation group I
FBXO5 F-box protein 5
FEN1 flap structure-specific endonuclease 1
FOXM1 forkhead box M1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
HAL histidine ammonia-lyase
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
IFI44L interferon-induced protein 44-like
IGF1R insulin-like growth factor 1 receptor
IGL immunoglobulin lambda locus
IRS2 insulin receptor substrate 2
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF15 kinesin family member 15
KIF18A kinesin family member 18A
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF22 kinesin family member 22
KIF23 kinesin family member 23
KIF4A kinesin family member 4A
KRT15 keratin 15, type I
LAMP5 lysosomal-associated membrane protein family, member 5
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LRP4 low density lipoprotein receptor-related protein 4
LTF lactotransferrin
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MMP7 matrix metallopeptidase 7
MSH2 mutS homolog 2
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NCAPH non-SMC condensin I complex, subunit H
NDC80 NDC80 kinetochore complex component
NEFL neurofilament, light polypeptide
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NEK2 NIMA-related kinase 2
NELL2 NEL-like 2 (chicken)
NLRP2 NLR family, pyrin domain containing 2
NRN1 neuritin 1
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
PRIM1 primase, DNA, polypeptide 1 (49kDa)
RACGAP1 Rac GTPase activating protein 1
RAD51 RAD51 recombinase
RAD51AP1 RAD51 associated protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RMI1 RecQ mediated genome instability 1
RNASEH2A ribonuclease H2, subunit A
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
S100P S100 calcium binding protein P
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SHCBP1 SHC SH2-domain binding protein 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMC2 structural maintenance of chromosomes 2
SMC4 structural maintenance of chromosomes 4
SNAP25 synaptosomal-associated protein, 25kDa
SPC25 SPC25, NDC80 kinetochore complex component
SPP1 secreted phosphoprotein 1
SRGN serglycin
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TBC1D31 TBC1 domain family, member 31
TEAD4 TEA domain family member 4
TFF1 trefoil factor 1
TIMELESS timeless circadian clock
TIPIN TIMELESS interacting protein
TK1 thymidine kinase 1, soluble
TMEM194A transmembrane protein 194A
TMPO thymopoietin
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TSPAN13 tetraspanin 13
TYMS thymidylate synthetase
UBE2S ubiquitin-conjugating enzyme E2S
VRK1 vaccinia related kinase 1
VSNL1 visinin-like 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZBTB18 zinc finger and BTB domain containing 18
ZWINT ZW10 interacting kinetochore protein