BRD-A19500257_geldanamycin_LNCAP_24_h_0.12_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

141 genes differentially expressed following the BRD-A19500257_geldanamycin_LNCAP_24_h_0.12_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ADGRE5 adhesion G protein-coupled receptor E5
BCAM basal cell adhesion molecule (Lutheran blood group)
BTG2 BTG family, member 2
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CD99 CD99 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
DPYSL3 dihydropyrimidinase-like 3
EFNB2 ephrin-B2
EGFL6 EGF-like-domain, multiple 6
EPHB2 EPH receptor B2
FOLR1 folate receptor 1 (adult)
GATA6 GATA binding protein 6
HSPA1A heat shock 70kDa protein 1A
HSPB1 heat shock 27kDa protein 1
IDS iduronate 2-sulfatase
IGFBP7 insulin-like growth factor binding protein 7
ITGAV integrin, alpha V
LAMP3 lysosomal-associated membrane protein 3
LAPTM4B lysosomal protein transmembrane 4 beta
LTBP2 latent transforming growth factor beta binding protein 2
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MYL9 myosin, light chain 9, regulatory
NRIP1 nuclear receptor interacting protein 1
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RBP1 retinol binding protein 1, cellular
REEP1 receptor accessory protein 1
RPL31 ribosomal protein L31
SELENBP1 selenium binding protein 1
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SESN1 sestrin 1
TM4SF1 transmembrane 4 L six family member 1
TOX thymocyte selection-associated high mobility group box
TOX3 TOX high mobility group box family member 3
TPM2 tropomyosin 2 (beta)
TPST2 tyrosylprotein sulfotransferase 2
TSC22D1 TSC22 domain family, member 1
WT1 Wilms tumor 1
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ACSL1 acyl-CoA synthetase long-chain family member 1
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CCNB2 cyclin B2
CDC20 cell division cycle 20
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHEK2 checkpoint kinase 2
CHPT1 choline phosphotransferase 1
CKAP4 cytoskeleton-associated protein 4
CKS1B CDC28 protein kinase regulatory subunit 1B
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FOXM1 forkhead box M1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPM6B glycoprotein M6B
H1FX H1 histone family, member X
H2AFX H2A histone family, member X
HMGB1 high mobility group box 1
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
IGF1R insulin-like growth factor 1 receptor
IGL immunoglobulin lambda locus
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
KDM5D lysine (K)-specific demethylase 5D
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF15 kinesin family member 15
KIF20A kinesin family member 20A
KRT15 keratin 15, type I
KRT23 keratin 23, type I
KRT5 keratin 5, type II
LBR lamin B receptor
LTF lactotransferrin
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAL mal, T-cell differentiation protein
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MKI67 marker of proliferation Ki-67
MMD monocyte to macrophage differentiation-associated
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAM1 neural cell adhesion molecule 1
NCAPG non-SMC condensin I complex, subunit G
NEK2 NIMA-related kinase 2
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
PCDH9 protocadherin 9
PCNA proliferating cell nuclear antigen
PLK1 polo-like kinase 1
PPAP2B phosphatidic acid phosphatase type 2B
PRC1 protein regulator of cytokinesis 1
PRIM1 primase, DNA, polypeptide 1 (49kDa)
RACGAP1 Rac GTPase activating protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RRM2 ribonucleotide reductase M2
SCGB2A2 secretoglobin, family 2A, member 2
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFRP1 secreted frizzled-related protein 1
SMC2 structural maintenance of chromosomes 2
SMC4 structural maintenance of chromosomes 4
STMN1 stathmin 1
TBC1D31 TBC1 domain family, member 31
TK1 thymidine kinase 1, soluble
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM194A transmembrane protein 194A
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TPD52L1 tumor protein D52-like 1
TPX2 TPX2, microtubule-associated
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein