BRD-A19500257_geldanamycin_HT29_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

411 genes differentially expressed following the BRD-A19500257_geldanamycin_HT29_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ABHD4 abhydrolase domain containing 4
ACKR3 atypical chemokine receptor 3
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
AFF1 AF4/FMR2 family, member 1
AGR2 anterior gradient 2
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALCAM activated leukocyte cell adhesion molecule
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ARID4B AT rich interactive domain 4B (RBP1-like)
ARMCX1 armadillo repeat containing, X-linked 1
ATP9A ATPase, class II, type 9A
ATRX alpha thalassemia/mental retardation syndrome X-linked
AUTS2 autism susceptibility candidate 2
BAG3 BCL2-associated athanogene 3
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BBX bobby sox homolog (Drosophila)
BCL6 B-cell CLL/lymphoma 6
BEX1 brain expressed, X-linked 1
BEX4 brain expressed, X-linked 4
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BRD8 bromodomain containing 8
C14ORF132 chromosome 14 open reading frame 132
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCDC28A coiled-coil domain containing 28A
CCNG1 cyclin G1
CCNG2 cyclin G2
CCNI cyclin I
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH17 cadherin 17, LI cadherin (liver-intestine)
CDK19 cyclin-dependent kinase 19
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CELF2 CUGBP, Elav-like family member 2
CEP57 centrosomal protein 57kDa
CEP70 centrosomal protein 70kDa
CERS6 ceramide synthase 6
CFLAR CASP8 and FADD-like apoptosis regulator
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLIC5 chloride intracellular channel 5
COL2A1 collagen, type II, alpha 1
CP ceruloplasmin (ferroxidase)
CSNK1D casein kinase 1, delta
CTSA cathepsin A
CTSV cathepsin V
CYFIP2 cytoplasmic FMR1 interacting protein 2
DAPK1 death-associated protein kinase 1
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
DEFB1 defensin, beta 1
DHRS3 dehydrogenase/reductase (SDR family) member 3
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
EFNA1 ephrin-A1
ELANE elastase, neutrophil expressed
EPCAM epithelial cell adhesion molecule
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
F13A1 coagulation factor XIII, A1 polypeptide
FAM114A1 family with sequence similarity 114, member A1
FAM134B family with sequence similarity 134, member B
FAM13A family with sequence similarity 13, member A
FAM13B family with sequence similarity 13, member B
FBN2 fibrillin 2
FGFR2 fibroblast growth factor receptor 2
FLRT3 fibronectin leucine rich transmembrane protein 3
FNBP1L formin binding protein 1-like
FOXO4 forkhead box O4
FTH1 ferritin, heavy polypeptide 1
FXR1 fragile X mental retardation, autosomal homolog 1
FZD2 frizzled class receptor 2
FZD5 frizzled class receptor 5
GABARAPL1 GABA(A) receptor-associated protein like 1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GJA1 gap junction protein, alpha 1, 43kDa
GLRX glutaredoxin (thioltransferase)
GLUL glutamate-ammonia ligase
GOLPH3L golgi phosphoprotein 3-like
GPNMB glycoprotein (transmembrane) nmb
GPR137B G protein-coupled receptor 137B
GPX3 glutathione peroxidase 3
GRAMD1C GRAM domain containing 1C
GULP1 GULP, engulfment adaptor PTB domain containing 1
GYG2 glycogenin 2
HBP1 HMG-box transcription factor 1
HECA headcase homolog (Drosophila)
HES1 hes family bHLH transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-E major histocompatibility complex, class I, E
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
IDO1 indoleamine 2,3-dioxygenase 1
IFI6 interferon, alpha-inducible protein 6
IGBP1 immunoglobulin (CD79A) binding protein 1
IGF1R insulin-like growth factor 1 receptor
INSIG1 insulin induced gene 1
INSR insulin receptor
IRS1 insulin receptor substrate 1
JMJD6 jumonji domain containing 6
KDM3A lysine (K)-specific demethylase 3A
KLF5 Kruppel-like factor 5 (intestinal)
KLHL24 kelch-like family member 24
KRT18 keratin 18, type I
KRT19 keratin 19, type I
LITAF lipopolysaccharide-induced TNF factor
LXN latexin
MAGED2 melanoma antigen family D2
MAOA monoamine oxidase A
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MARCKSL1 MARCKS-like 1
MATN2 matrilin 2
MFAP5 microfibrillar associated protein 5
MKNK2 MAP kinase interacting serine/threonine kinase 2
MKRN1 makorin ring finger protein 1
MME membrane metallo-endopeptidase
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MTUS1 microtubule associated tumor suppressor 1
MXI1 MAX interactor 1, dimerization protein
MYB v-myb avian myeloblastosis viral oncogene homolog
MYO6 myosin VI
NARF nuclear prelamin A recognition factor
NARFL nuclear prelamin A recognition factor-like
NAV2 neuron navigator 2
NBPF10 neuroblastoma breakpoint family, member 10
NCK2 NCK adaptor protein 2
NDRG1 N-myc downstream regulated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEBL nebulette
NEU1 sialidase 1 (lysosomal sialidase)
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NOTCH2NL notch 2 N-terminal like
NPC2 Niemann-Pick disease, type C2
NTS neurotensin
NUCB2 nucleobindin 2
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9
NUPR1 nuclear protein, transcriptional regulator, 1
OARD1 O-acyl-ADP-ribose deacylase 1
OGDHL oxoglutarate dehydrogenase-like
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PAN2 PAN2 poly(A) specific ribonuclease subunit
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDZK1 PDZ domain containing 1
PEG10 paternally expressed 10
PERP PERP, TP53 apoptosis effector
PHYH phytanoyl-CoA 2-hydroxylase
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PJA2 praja ring finger 2, E3 ubiquitin protein ligase
PROM1 prominin 1
PROS1 protein S (alpha)
PRSS8 protease, serine, 8
PTOV1 prostate tumor overexpressed 1
PXDN peroxidasin
QPCT glutaminyl-peptide cyclotransferase
QPRT quinolinate phosphoribosyltransferase
RAB13 RAB13, member RAS oncogene family
RAB15 RAB15, member RAS oncogene family
RAB17 RAB17, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RB1CC1 RB1-inducible coiled-coil 1
RNF130 ring finger protein 130
SARAF store-operated calcium entry-associated regulatory factor
SC5D sterol-C5-desaturase
SCGB2A1 secretoglobin, family 2A, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCPEP1 serine carboxypeptidase 1
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SERINC5 serine incorporator 5
SESN1 sestrin 1
SGK1 serum/glucocorticoid regulated kinase 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLPI secretory leukocyte peptidase inhibitor
SNX3 sorting nexin 3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
SPEN spen family transcriptional repressor
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STK38 serine/threonine kinase 38
STXBP1 syntaxin binding protein 1
STXBP2 syntaxin binding protein 2
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SYF2 SYF2 pre-mRNA-splicing factor
SYNE2 spectrin repeat containing, nuclear envelope 2
TACC2 transforming, acidic coiled-coil containing protein 2
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TMC5 transmembrane channel-like 5
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOX3 TOX high mobility group box family member 3
TPP1 tripeptidyl peptidase I
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
TSPAN13 tetraspanin 13
TTC39A tetratricopeptide repeat domain 39A
TUBA1A tubulin, alpha 1a
UGDH UDP-glucose 6-dehydrogenase
UQCRB ubiquinol-cytochrome c reductase binding protein
USP3 ubiquitin specific peptidase 3
USP9X ubiquitin specific peptidase 9, X-linked
VAMP8 vesicle-associated membrane protein 8
VSIG4 V-set and immunoglobulin domain containing 4
WDR19 WD repeat domain 19
WDTC1 WD and tetratricopeptide repeats 1
WIF1 WNT inhibitory factor 1
WLS wntless Wnt ligand secretion mediator
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)
ZMYM2 zinc finger, MYM-type 2
ZMYND8 zinc finger, MYND-type containing 8
ZNF277 zinc finger protein 277
ZNF292 zinc finger protein 292
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ACTG2 actin, gamma 2, smooth muscle, enteric
ADGRE5 adhesion G protein-coupled receptor E5
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AK4 adenylate kinase 4
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
AREG amphiregulin
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
BOP1 block of proliferation 1
BYSL bystin-like
C1QBP complement component 1, q subcomponent binding protein
C7 complement component 7
CCDC85B coiled-coil domain containing 85B
CD320 CD320 molecule
CD3EAP CD3e molecule, epsilon associated protein
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDK4 cyclin-dependent kinase 4
CEMIP cell migration inducing protein, hyaluronan binding
CKLF chemokine-like factor
COCH cochlin
COL1A1 collagen, type I, alpha 1
COL3A1 collagen, type III, alpha 1
CSRP1 cysteine and glycine-rich protein 1
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CTPS1 CTP synthase 1
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEGS1 delta(4)-desaturase, sphingolipid 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DLEU1 deleted in lymphocytic leukemia 1 (non-protein coding)
DPH2 DPH2 homolog (S. cerevisiae)
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
EAF2 ELL associated factor 2
EDNRA endothelin receptor type A
EFNB2 ephrin-B2
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
ELOVL6 ELOVL fatty acid elongase 6
EMG1 EMG1 N1-specific pseudouridine methyltransferase
EML3 echinoderm microtubule associated protein like 3
EREG epiregulin
EXOSC2 exosome component 2
EXOSC4 exosome component 4
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F12 coagulation factor XII (Hageman factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FAM216A family with sequence similarity 216, member A
FAM57A family with sequence similarity 57, member A
FAS Fas cell surface death receptor
FEN1 flap structure-specific endonuclease 1
FKBP11 FK506 binding protein 11, 19 kDa
FOSL1 FOS-like antigen 1
FRZB frizzled-related protein
GAL galanin/GMAP prepropeptide
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
GATA2 GATA binding protein 2
GEMIN4 gem (nuclear organelle) associated protein 4
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLRX2 glutaredoxin 2
GRWD1 glutamate-rich WD repeat containing 1
HBEGF heparin-binding EGF-like growth factor
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
IARS isoleucyl-tRNA synthetase
IER2 immediate early response 2
IER3 immediate early response 3
IFRD2 interferon-related developmental regulator 2
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
ISOC1 isochorismatase domain containing 1
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KIAA0020 KIAA0020
KLF4 Kruppel-like factor 4 (gut)
KLK6 kallikrein-related peptidase 6
LIF leukemia inhibitory factor
LOXL1 lysyl oxidase-like 1
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAOB monoamine oxidase B
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MINA MYC induced nuclear antigen
MRPL3 mitochondrial ribosomal protein L3
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MSH6 mutS homolog 6
MTCL1 microtubule crosslinking factor 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYLK myosin light chain kinase
NAV3 neuron navigator 3
NES nestin
NHP2 NHP2 ribonucleoprotein
NID2 nidogen 2 (osteonidogen)
NME1 NME/NM23 nucleoside diphosphate kinase 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae)
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NOP56 NOP56 ribonucleoprotein
NPM3 nucleophosmin/nucleoplasmin 3
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NUP210 nucleoporin 210kDa
NXT1 nuclear transport factor 2-like export factor 1
ODC1 ornithine decarboxylase 1
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PCNA proliferating cell nuclear antigen
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PMP22 peripheral myelin protein 22
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPARG peroxisome proliferator-activated receptor gamma
PPAT phosphoribosyl pyrophosphate amidotransferase
PPIF peptidylprolyl isomerase F
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PRKRIR protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTRF polymerase I and transcript release factor
PUS1 pseudouridylate synthase 1
PUS7 pseudouridylate synthase 7 (putative)
PXMP2 peroxisomal membrane protein 2, 22kDa
PYCR1 pyrroline-5-carboxylate reductase 1
RAB20 RAB20, member RAS oncogene family
RAD51 RAD51 recombinase
RANBP1 RAN binding protein 1
RPP40 ribonuclease P/MRP 40kDa subunit
RPS4Y1 ribosomal protein S4, Y-linked 1
RRM2 ribonucleotide reductase M2
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RTN1 reticulon 1
RUVBL1 RuvB-like AAA ATPase 1
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
SACS sacsin molecular chaperone
SCGB2A2 secretoglobin, family 2A, member 2
SEH1L SEH1-like (S. cerevisiae)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFN stratifin
SMAD1 SMAD family member 1
SNAI2 snail family zinc finger 2
SOWAHC sosondowah ankyrin repeat domain family member C
SPRR1A small proline-rich protein 1A
SRM spermidine synthase
TFRC transferrin receptor
TGFA transforming growth factor, alpha
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TIAM1 T-cell lymphoma invasion and metastasis 1
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TIPIN TIMELESS interacting protein
TM4SF1 transmembrane 4 L six family member 1
TMEM109 transmembrane protein 109
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNC tenascin C
TRIP13 thyroid hormone receptor interactor 13
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSPAN4 tetraspanin 4
TYMP thymidine phosphorylase
TYMS thymidylate synthetase
UNG uracil-DNA glycosylase
WEE1 WEE1 G2 checkpoint kinase
WNT5A wingless-type MMTV integration site family, member 5A