BRD-A19500257_geldanamycin_HT29_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

380 genes differentially expressed following the BRD-A19500257_geldanamycin_HT29_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACSF2 acyl-CoA synthetase family member 2
ADD3 adducin 3 (gamma)
AFF1 AF4/FMR2 family, member 1
AKAP9 A kinase (PRKA) anchor protein 9
ALCAM activated leukocyte cell adhesion molecule
AMACR alpha-methylacyl-CoA racemase
ANO10 anoctamin 10
ANXA4 annexin A4
ARID4B AT rich interactive domain 4B (RBP1-like)
ARMCX1 armadillo repeat containing, X-linked 1
ASS1 argininosuccinate synthase 1
ATP9A ATPase, class II, type 9A
ATRX alpha thalassemia/mental retardation syndrome X-linked
AZU1 azurocidin 1
BACE2 beta-site APP-cleaving enzyme 2
BAG3 BCL2-associated athanogene 3
BASP1 brain abundant, membrane attached signal protein 1
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BECN1 beclin 1, autophagy related
BEX1 brain expressed, X-linked 1
BID BH3 interacting domain death agonist
BPTF bromodomain PHD finger transcription factor
BRD8 bromodomain containing 8
BTN3A2 butyrophilin, subfamily 3, member A2
C1ORF115 chromosome 1 open reading frame 115
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCDC28A coiled-coil domain containing 28A
CCNB2 cyclin B2
CCNG1 cyclin G1
CCNG2 cyclin G2
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDH17 cadherin 17, LI cadherin (liver-intestine)
CDK19 cyclin-dependent kinase 19
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CELF2 CUGBP, Elav-like family member 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLCA1 chloride channel accessory 1
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COLEC12 collectin sub-family member 12
CP ceruloplasmin (ferroxidase)
CRISP3 cysteine-rich secretory protein 3
CRYAB crystallin, alpha B
CTSA cathepsin A
CTSG cathepsin G
DAPK1 death-associated protein kinase 1
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
DEFB1 defensin, beta 1
DLK1 delta-like 1 homolog (Drosophila)
EHF ets homologous factor
ELANE elastase, neutrophil expressed
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ERBB4 erb-b2 receptor tyrosine kinase 4
FAM117A family with sequence similarity 117, member A
FAM13A family with sequence similarity 13, member A
FCGBP Fc fragment of IgG binding protein
FGFR2 fibroblast growth factor receptor 2
FOXO4 forkhead box O4
FTH1 ferritin, heavy polypeptide 1
FXR1 fragile X mental retardation, autosomal homolog 1
FZD2 frizzled class receptor 2
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45B growth arrest and DNA-damage-inducible, beta
GLRX glutaredoxin (thioltransferase)
GLUL glutamate-ammonia ligase
GOLGA8A golgin A8 family, member A
GPRC5B G protein-coupled receptor, class C, group 5, member B
GPX3 glutathione peroxidase 3
GRAMD3 GRAM domain containing 3
GSDMB gasdermin B
GULP1 GULP, engulfment adaptor PTB domain containing 1
GYG2 glycogenin 2
HBP1 HMG-box transcription factor 1
HECA headcase homolog (Drosophila)
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HLA-E major histocompatibility complex, class I, E
HOOK2 hook microtubule-tethering protein 2
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
IDO1 indoleamine 2,3-dioxygenase 1
IFI27 interferon, alpha-inducible protein 27
IGBP1 immunoglobulin (CD79A) binding protein 1
IL7R interleukin 7 receptor
IRS2 insulin receptor substrate 2
JMJD6 jumonji domain containing 6
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1
KDM3A lysine (K)-specific demethylase 3A
KLHL24 kelch-like family member 24
LBH limb bud and heart development
LCN2 lipocalin 2
LETMD1 LETM1 domain containing 1
LUC7L3 LUC7-like 3 (S. cerevisiae)
LXN latexin
LYZ lysozyme
MAGEA12 melanoma antigen family A12
MAGED2 melanoma antigen family D2
MAOA monoamine oxidase A
MDK midkine (neurite growth-promoting factor 2)
MKRN1 makorin ring finger protein 1
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MUC4 mucin 4, cell surface associated
MUC5B mucin 5B, oligomeric mucus/gel-forming
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
MYB v-myb avian myeloblastosis viral oncogene homolog
MYO6 myosin VI
N4BP2L2 NEDD4 binding protein 2-like 2
NARF nuclear prelamin A recognition factor
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NNT nicotinamide nucleotide transhydrogenase
NPC2 Niemann-Pick disease, type C2
NPTX2 neuronal pentraxin II
NXF3 nuclear RNA export factor 3
OBSL1 obscurin-like 1
OGDHL oxoglutarate dehydrogenase-like
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDIA5 protein disulfide isomerase family A, member 5
PDZK1IP1 PDZK1 interacting protein 1
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PILRB paired immunoglobin-like type 2 receptor beta
PIN4 peptidylprolyl cis/trans isomerase, NIMA-interacting 4
PNRC1 proline-rich nuclear receptor coactivator 1
POFUT2 protein O-fucosyltransferase 2
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PROM1 prominin 1
PTPRK protein tyrosine phosphatase, receptor type, K
PTTG1IP pituitary tumor-transforming 1 interacting protein
QPRT quinolinate phosphoribosyltransferase
RAB13 RAB13, member RAS oncogene family
RAB17 RAB17, member RAS oncogene family
RABGAP1L RAB GTPase activating protein 1-like
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RB1CC1 RB1-inducible coiled-coil 1
RBL2 retinoblastoma-like 2
RNF130 ring finger protein 130
SC5D sterol-C5-desaturase
SCPEP1 serine carboxypeptidase 1
SELENBP1 selenium binding protein 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SESN1 sestrin 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLPI secretory leukocyte peptidase inhibitor
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
SPON2 spondin 2, extracellular matrix protein
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STAR steroidogenic acute regulatory protein
STXBP1 syntaxin binding protein 1
STXBP2 syntaxin binding protein 2
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SYNE2 spectrin repeat containing, nuclear envelope 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TMC5 transmembrane channel-like 5
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOX thymocyte selection-associated high mobility group box
TOX3 TOX high mobility group box family member 3
TPD52L1 tumor protein D52-like 1
TPP1 tripeptidyl peptidase I
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
TSPAN13 tetraspanin 13
TTC3 tetratricopeptide repeat domain 3
TXNIP thioredoxin interacting protein
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UFC1 ubiquitin-fold modifier conjugating enzyme 1
UGDH UDP-glucose 6-dehydrogenase
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
VWA5A von Willebrand factor A domain containing 5A
WDTC1 WD and tetratricopeptide repeats 1
WFDC2 WAP four-disulfide core domain 2
WIPI1 WD repeat domain, phosphoinositide interacting 1
WSB1 WD repeat and SOCS box containing 1
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)
ZKSCAN1 zinc finger with KRAB and SCAN domains 1
ZMYM2 zinc finger, MYM-type 2
ZMYND8 zinc finger, MYND-type containing 8

decreased expression

Symbol Name
ADGRE5 adhesion G protein-coupled receptor E5
ADK adenosine kinase
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AK4 adenylate kinase 4
ARF6 ADP-ribosylation factor 6
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATAD2 ATPase family, AAA domain containing 2
BOP1 block of proliferation 1
BYSL bystin-like
C1QBP complement component 1, q subcomponent binding protein
CCDC85B coiled-coil domain containing 85B
CCDC86 coiled-coil domain containing 86
CCND2 cyclin D2
CCNE2 cyclin E2
CCNF cyclin F
CD200 CD200 molecule
CD3EAP CD3e molecule, epsilon associated protein
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CENPU centromere protein U
CKLF chemokine-like factor
CPE carboxypeptidase E
CREB1 cAMP responsive element binding protein 1
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CTPS1 CTP synthase 1
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL14 chemokine (C-X-C motif) ligand 14
CYR61 cysteine-rich, angiogenic inducer, 61
DCTPP1 dCTP pyrophosphatase 1
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
ECM2 extracellular matrix protein 2, female organ and adipocyte specific
EDNRA endothelin receptor type A
EGR1 early growth response 1
EGR2 early growth response 2
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EIF4E eukaryotic translation initiation factor 4E
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF5A eukaryotic translation initiation factor 5A
ELOVL6 ELOVL fatty acid elongase 6
EMG1 EMG1 N1-specific pseudouridine methyltransferase
EMP1 epithelial membrane protein 1
ENDOD1 endonuclease domain containing 1
EREG epiregulin
EXOSC4 exosome component 4
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F12 coagulation factor XII (Hageman factor)
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM129A family with sequence similarity 129, member A
FAM216A family with sequence similarity 216, member A
FAM57A family with sequence similarity 57, member A
FAS Fas cell surface death receptor
FEN1 flap structure-specific endonuclease 1
FJX1 four jointed box 1 (Drosophila)
FOSL1 FOS-like antigen 1
FRZB frizzled-related protein
GATA2 GATA binding protein 2
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLRX2 glutaredoxin 2
GRWD1 glutamate-rich WD repeat containing 1
H2AFX H2A histone family, member X
HBB hemoglobin, beta
HK2 hexokinase 2
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HOPX HOP homeobox
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFI44L interferon-induced protein 44-like
IFIT5 interferon-induced protein with tetratricopeptide repeats 5
IFRD2 interferon-related developmental regulator 2
IGF1 insulin-like growth factor 1 (somatomedin C)
IPO5 importin 5
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4
KIAA0020 KIAA0020
KLF4 Kruppel-like factor 4 (gut)
KRT6B keratin 6B, type II
LMNA lamin A/C
LOXL1 lysyl oxidase-like 1
MAK16 MAK16 homolog (S. cerevisiae)
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MPZL2 myelin protein zero-like 2
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MSH6 mutS homolog 6
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYLK myosin light chain kinase
NDUFAF4 NADH dehydrogenase (ubiquinone) complex I, assembly factor 4
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae)
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NOP56 NOP56 ribonucleoprotein
NXT1 nuclear transport factor 2-like export factor 1
ODC1 ornithine decarboxylase 1
OGN osteoglycin
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PAK1IP1 PAK1 interacting protein 1
PCNA proliferating cell nuclear antigen
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLN phospholamban
PNO1 partner of NOB1 homolog (S. cerevisiae)
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPARG peroxisome proliferator-activated receptor gamma
PPAT phosphoribosyl pyrophosphate amidotransferase
PPIF peptidylprolyl isomerase F
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PTGIS prostaglandin I2 (prostacyclin) synthase
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PUS7 pseudouridylate synthase 7 (putative)
RAB20 RAB20, member RAS oncogene family
RAD51 RAD51 recombinase
RANBP1 RAN binding protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RGS5 regulator of G-protein signaling 5
RPP40 ribonuclease P/MRP 40kDa subunit
RPS11 ribosomal protein S11
RRM2 ribonucleotide reductase M2
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SACS sacsin molecular chaperone
SCGB2A2 secretoglobin, family 2A, member 2
SEH1L SEH1-like (S. cerevisiae)
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFN stratifin
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLK STE20-like kinase
SMYD2 SET and MYND domain containing 2
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa
SORD sorbitol dehydrogenase
SOWAHC sosondowah ankyrin repeat domain family member C
SPARCL1 SPARC-like 1 (hevin)
SPINK5 serine peptidase inhibitor, Kazal type 5
SRM spermidine synthase
SRSF6 serine/arginine-rich splicing factor 6
TACSTD2 tumor-associated calcium signal transducer 2
TCF4 transcription factor 4
TFAM transcription factor A, mitochondrial
TFRC transferrin receptor
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TIPIN TIMELESS interacting protein
TM4SF1 transmembrane 4 L six family member 1
TMEM109 transmembrane protein 109
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TOP2A topoisomerase (DNA) II alpha 170kDa
TRAPPC4 trafficking protein particle complex 4
TSPAN4 tetraspanin 4
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UPP1 uridine phosphorylase 1
VWF von Willebrand factor
WDR43 WD repeat domain 43
WEE1 WEE1 G2 checkpoint kinase
ZWINT ZW10 interacting kinetochore protein