BRD-A19500257_geldanamycin_HS578T_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

168 genes differentially expressed following the BRD-A19500257_geldanamycin_HS578T_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL3 acyl-CoA synthetase long-chain family member 3
ADCY7 adenylate cyclase 7
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
BAG3 BCL2-associated athanogene 3
CADM1 cell adhesion molecule 1
CAPN6 calpain 6
CBS cystathionine-beta-synthase
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COL2A1 collagen, type II, alpha 1
CRELD2 cysteine-rich with EGF-like domains 2
CXCL13 chemokine (C-X-C motif) ligand 13
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DIO2 deiodinase, iodothyronine, type II
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FGG fibrinogen gamma chain
FOXF2 forkhead box F2
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BG histone cluster 1, H2bg
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMOX1 heme oxygenase 1
HOMER2 homer scaffolding protein 2
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
HYOU1 hypoxia up-regulated 1
IER5 immediate early response 5
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGLJ3 immunoglobulin lambda joining 3
INHBE inhibin, beta E
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JCHAIN joining chain of multimeric IgA and IgM
KDM5D lysine (K)-specific demethylase 5D
KIZ kizuna centrosomal protein
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
MANF mesencephalic astrocyte-derived neurotrophic factor
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MSX1 msh homeobox 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEFL neurofilament, light polypeptide
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NUPR1 nuclear protein, transcriptional regulator, 1
PDIA6 protein disulfide isomerase family A, member 6
PDZD2 PDZ domain containing 2
PEX11A peroxisomal biogenesis factor 11 alpha
PLBD1 phospholipase B domain containing 1
PLK2 polo-like kinase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PSPH phosphoserine phosphatase
RAD9A RAD9 homolog A (S. pombe)
RGS2 regulator of G-protein signaling 2
RGS4 regulator of G-protein signaling 4
RHOB ras homolog family member B
SFTPA2 surfactant protein A2
SIK1 salt-inducible kinase 1
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TRIB3 tribbles pseudokinase 3
TSPAN13 tetraspanin 13
USP6NL USP6 N-terminal like
WARS tryptophanyl-tRNA synthetase
WASF3 WAS protein family, member 3
WIF1 WNT inhibitory factor 1
XBP1 X-box binding protein 1

decreased expression

Symbol Name
ADCK3 aarF domain containing kinase 3
ADM adrenomedullin
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
AREG amphiregulin
ASPH aspartate beta-hydroxylase
BHLHE41 basic helix-loop-helix family, member e41
BMP2 bone morphogenetic protein 2
BST2 bone marrow stromal cell antigen 2
C10ORF10 chromosome 10 open reading frame 10
CA2 carbonic anhydrase II
CAV1 caveolin 1, caveolae protein, 22kDa
CD200 CD200 molecule
CD24 CD24 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CPA3 carboxypeptidase A3 (mast cell)
CTSG cathepsin G
CXCL6 chemokine (C-X-C motif) ligand 6
CXCL8 chemokine (C-X-C motif) ligand 8
DPYSL3 dihydropyrimidinase-like 3
EMP1 epithelial membrane protein 1
ESRP1 epithelial splicing regulatory protein 1
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FST follistatin
FZD7 frizzled class receptor 7
GAL galanin/GMAP prepropeptide
GOLT1B golgi transport 1B
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HES1 hes family bHLH transcription factor 1
HMG20B high mobility group 20B
HOXA5 homeobox A5
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
KLK10 kallikrein-related peptidase 10
KRT18 keratin 18, type I
KRT6B keratin 6B, type II
LMCD1 LIM and cysteine-rich domains 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP7 microtubule-associated protein 7
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NID1 nidogen 1
NTS neurotensin
PECAM1 platelet/endothelial cell adhesion molecule 1
PERP PERP, TP53 apoptosis effector
PHLDA2 pleckstrin homology-like domain, family A, member 2
PI3 peptidase inhibitor 3, skin-derived
PIP prolactin-induced protein
PLAGL1 pleiomorphic adenoma gene-like 1
PPAP2C phosphatidic acid phosphatase type 2C
PRDX2 peroxiredoxin 2
PUF60 poly-U binding splicing factor 60KDa
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SOX11 SRY (sex determining region Y)-box 11
SPON1 spondin 1, extracellular matrix protein
SPP1 secreted phosphoprotein 1
STAR steroidogenic acute regulatory protein
SYNM synemin, intermediate filament protein
TACSTD2 tumor-associated calcium signal transducer 2
TFF1 trefoil factor 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF1 transmembrane 4 L six family member 1
TMSB15A thymosin beta 15a
TNC tenascin C
TNIK TRAF2 and NCK interacting kinase
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TSPAN4 tetraspanin 4
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
VCAM1 vascular cell adhesion molecule 1
VCAN versican