BRD-A19500257_geldanamycin_HS578T_3_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

158 genes differentially expressed following the BRD-A19500257_geldanamycin_HS578T_3_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
AQP3 aquaporin 3 (Gill blood group)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
BAG3 BCL2-associated athanogene 3
C4BPA complement component 4 binding protein, alpha
C6ORF62 chromosome 6 open reading frame 62
CACYBP calcyclin binding protein
CD200 CD200 molecule
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CECR1 cat eye syndrome chromosome region, candidate 1
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CP ceruloplasmin (ferroxidase)
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EYA2 EYA transcriptional coactivator and phosphatase 2
FAM134B family with sequence similarity 134, member B
FBXO11 F-box protein 11
FGFR2 fibroblast growth factor receptor 2
GPM6B glycoprotein M6B
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPE1 heat shock 10kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV3-20 immunoglobulin kappa variable 3-20
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IL6R interleukin 6 receptor
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
KRT5 keratin 5, type II
LOC100505650 uncharacterized LOC100505650
MAP2K5 mitogen-activated protein kinase kinase 5
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MT1E metallothionein 1E
MT1X metallothionein 1X
MTSS1 metastasis suppressor 1
MUC16 mucin 16, cell surface associated
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RPS11 ribosomal protein S11
SAT1 spermidine/spermine N1-acetyltransferase 1
SEPW1 selenoprotein W, 1
SFTPA2 surfactant protein A2
SFTPC surfactant protein C
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
TFPI2 tissue factor pathway inhibitor 2
TREM1 triggering receptor expressed on myeloid cells 1
TSPAN13 tetraspanin 13
TSPYL5 TSPY-like 5
TUBB2A tubulin, beta 2A class IIa
WFDC2 WAP four-disulfide core domain 2

decreased expression

Symbol Name
ADCK3 aarF domain containing kinase 3
ADIPOQ adiponectin, C1Q and collagen domain containing
ADRB2 adrenoceptor beta 2, surface
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMIGO2 adhesion molecule with Ig-like domain 2
AREG amphiregulin
ASS1 argininosuccinate synthase 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BHLHE41 basic helix-loop-helix family, member e41
BLNK B-cell linker
C1R complement component 1, r subcomponent
CCNF cyclin F
CD1E CD1e molecule
CD36 CD36 molecule (thrombospondin receptor)
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CLIC3 chloride intracellular channel 3
CPE carboxypeptidase E
CXCL12 chemokine (C-X-C motif) ligand 12
CXCR4 chemokine (C-X-C motif) receptor 4
DEPTOR DEP domain containing MTOR-interacting protein
DHCR24 24-dehydrocholesterol reductase
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EMX2 empty spiracles homeobox 2
EREG epiregulin
ESR1 estrogen receptor 1
FABP4 fatty acid binding protein 4, adipocyte
FHL1 four and a half LIM domains 1
FOSL1 FOS-like antigen 1
FST follistatin
FZD7 frizzled class receptor 7
GREB1 growth regulation by estrogen in breast cancer 1
HES1 hes family bHLH transcription factor 1
HOXA5 homeobox A5
HOXC6 homeobox C6
IER3 immediate early response 3
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
KAZN kazrin, periplakin interacting protein
KIAA1033 KIAA1033
LAMA3 laminin, alpha 3
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP7 microtubule-associated protein 7
MGLL monoglyceride lipase
MGP matrix Gla protein
MMP7 matrix metallopeptidase 7
MSLN mesothelin
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOTCH2 notch 2
NPY1R neuropeptide Y receptor Y1
ORC1 origin recognition complex, subunit 1
PDZK1 PDZ domain containing 1
PEG3 paternally expressed 3
PRSS2 protease, serine, 2 (trypsin 2)
PRSS3 protease, serine, 3
RBP1 retinol binding protein 1, cellular
RHOBTB3 Rho-related BTB domain containing 3
S100P S100 calcium binding protein P
SCG5 secretogranin V
SCGB2A1 secretoglobin, family 2A, member 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SOBP sine oculis binding protein homolog (Drosophila)
STAR steroidogenic acute regulatory protein
STC1 stanniocalcin 1
TACSTD2 tumor-associated calcium signal transducer 2
TFF1 trefoil factor 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNNT1 troponin T type 1 (skeletal, slow)
TXNIP thioredoxin interacting protein
VCAM1 vascular cell adhesion molecule 1
VGLL4 vestigial-like family member 4
ZHX2 zinc fingers and homeoboxes 2
ZMYM2 zinc finger, MYM-type 2