BRD-A19500257_geldanamycin_HS578T_3_h_0.12_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

112 genes differentially expressed following the BRD-A19500257_geldanamycin_HS578T_3_h_0.12_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
CASP7 caspase 7, apoptosis-related cysteine peptidase
CAST calpastatin
CD8A CD8a molecule
COL1A2 collagen, type I, alpha 2
COL2A1 collagen, type II, alpha 1
CORO1A coronin, actin binding protein, 1A
CXCL5 chemokine (C-X-C motif) ligand 5
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFB1 defensin, beta 1
DENND2D DENN/MADD domain containing 2D
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
FGFR3 fibroblast growth factor receptor 3
FLRT3 fibronectin leucine rich transmembrane protein 3
GUSBP11 glucuronidase, beta pseudogene 11
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
GZMK granzyme K (granzyme 3; tryptase II)
HMOX1 heme oxygenase 1
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IFITM1 interferon induced transmembrane protein 1
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
JCHAIN joining chain of multimeric IgA and IgM
KRT15 keratin 15, type I
KRT5 keratin 5, type II
LAPTM4B lysosomal protein transmembrane 4 beta
MAOB monoamine oxidase B
MATN2 matrilin 2
MTSS1 metastasis suppressor 1
MXRA7 matrix-remodelling associated 7
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NELL2 NEL-like 2 (chicken)
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
PAN2 PAN2 poly(A) specific ribonuclease subunit
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDZK1 PDZ domain containing 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLS3 plastin 3
PVRIG poliovirus receptor related immunoglobulin domain containing
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RGS2 regulator of G-protein signaling 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFN stratifin
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
TACSTD2 tumor-associated calcium signal transducer 2
TFPI2 tissue factor pathway inhibitor 2
TMEM47 transmembrane protein 47
TOX thymocyte selection-associated high mobility group box
TPBG trophoblast glycoprotein
TRBC1 T cell receptor beta constant 1
TSPAN13 tetraspanin 13
TSPAN8 tetraspanin 8
TSPYL5 TSPY-like 5
TUBB2A tubulin, beta 2A class IIa

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
AREG amphiregulin
BHLHE41 basic helix-loop-helix family, member e41
CALML5 calmodulin-like 5
CD36 CD36 molecule (thrombospondin receptor)
COL11A1 collagen, type XI, alpha 1
CYBA cytochrome b-245, alpha polypeptide
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DEPTOR DEP domain containing MTOR-interacting protein
FABP4 fatty acid binding protein 4, adipocyte
FAS Fas cell surface death receptor
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GPX1 glutathione peroxidase 1
HES1 hes family bHLH transcription factor 1
HHEX hematopoietically expressed homeobox
IER3 immediate early response 3
JAG1 jagged 1
KIAA1033 KIAA1033
KIF5C kinesin family member 5C
KYNU kynureninase
LTF lactotransferrin
MAP7 microtubule-associated protein 7
NR2F2 nuclear receptor subfamily 2, group F, member 2
PRR15L proline rich 15-like
S100P S100 calcium binding protein P
SCG5 secretogranin V
SCGB1D2 secretoglobin, family 1D, member 2
SFRP4 secreted frizzled-related protein 4
SNAP25 synaptosomal-associated protein, 25kDa
SNX10 sorting nexin 10
SRPX sushi-repeat containing protein, X-linked
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
SYBU syntabulin (syntaxin-interacting)
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TFF3 trefoil factor 3 (intestinal)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM158 transmembrane protein 158 (gene/pseudogene)
TOX3 TOX high mobility group box family member 3
TRAPPC3 trafficking protein particle complex 3