BRD-A19500257_geldanamycin_HS578T_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

57 genes differentially expressed following the BRD-A19500257_geldanamycin_HS578T_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
C3 complement component 3
C6ORF62 chromosome 6 open reading frame 62
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CD163 CD163 molecule
CFB complement factor B
COL1A1 collagen, type I, alpha 1
CP ceruloplasmin (ferroxidase)
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EIF5A eukaryotic translation initiation factor 5A
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IGF1R insulin-like growth factor 1 receptor
KDM5A lysine (K)-specific demethylase 5A
LCN2 lipocalin 2
MAN1C1 mannosidase, alpha, class 1C, member 1
MSLN mesothelin
PDZK1IP1 PDZK1 interacting protein 1
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RPS27L ribosomal protein S27-like
SOD2 superoxide dismutase 2, mitochondrial
SOX9 SRY (sex determining region Y)-box 9
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TWIST1 twist family bHLH transcription factor 1

decreased expression

Symbol Name
ADGRF5 adhesion G protein-coupled receptor F5
DEPTOR DEP domain containing MTOR-interacting protein
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FGF13 fibroblast growth factor 13
GULP1 GULP, engulfment adaptor PTB domain containing 1
H1F0 H1 histone family, member 0
HHEX hematopoietically expressed homeobox
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
IPO13 importin 13
KRT18 keratin 18, type I
LGALS3 lectin, galactoside-binding, soluble, 3
LYST lysosomal trafficking regulator
MAOA monoamine oxidase A
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
RNH1 ribonuclease/angiogenin inhibitor 1
SCGB2A2 secretoglobin, family 2A, member 2
SPP1 secreted phosphoprotein 1
STC1 stanniocalcin 1
TFF3 trefoil factor 3 (intestinal)
TRIM2 tripartite motif containing 2