BRD-A19500257_geldanamycin_HS578T_24_h_0.12_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

302 genes differentially expressed following the BRD-A19500257_geldanamycin_HS578T_24_h_0.12_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACSL3 acyl-CoA synthetase long-chain family member 3
ADAM10 ADAM metallopeptidase domain 10
ADGRG6 adhesion G protein-coupled receptor G6
AFF1 AF4/FMR2 family, member 1
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
APOL1 apolipoprotein L, 1
AQP3 aquaporin 3 (Gill blood group)
ARG2 arginase 2
ARID4B AT rich interactive domain 4B (RBP1-like)
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ASS1 argininosuccinate synthase 1
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BBX bobby sox homolog (Drosophila)
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BID BH3 interacting domain death agonist
BRD8 bromodomain containing 8
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CA12 carbonic anhydrase XII
CALCA calcitonin-related polypeptide alpha
CCL20 chemokine (C-C motif) ligand 20
CCNB2 cyclin B2
CCNG1 cyclin G1
CCNI cyclin I
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CD1E CD1e molecule
CD24 CD24 molecule
CDC25B cell division cycle 25B
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CENPE centromere protein E, 312kDa
CFB complement factor B
CHEK2 checkpoint kinase 2
CHN1 chimerin 1
CKS2 CDC28 protein kinase regulatory subunit 2
COL3A1 collagen, type III, alpha 1
COL4A5 collagen, type IV, alpha 5
CRABP1 cellular retinoic acid binding protein 1
CRYZ crystallin, zeta (quinone reductase)
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCP2 decapping mRNA 2
DEFB1 defensin, beta 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
EFNA1 ephrin-A1
FABP6 fatty acid binding protein 6, ileal
FAM114A1 family with sequence similarity 114, member A1
FAM13A family with sequence similarity 13, member A
FAM171A1 family with sequence similarity 171, member A1
FLNB filamin B, beta
FOXJ3 forkhead box J3
FRS2 fibroblast growth factor receptor substrate 2
FXR1 fragile X mental retardation, autosomal homolog 1
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GOLM1 golgi membrane protein 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
HACD3 3-hydroxyacyl-CoA dehydratase 3
HMGB3 high mobility group box 3
HMMR hyaluronan-mediated motility receptor (RHAMM)
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB8 heat shock 22kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IGL immunoglobulin lambda locus
IRX5 iroquois homeobox 5
ITM2C integral membrane protein 2C
JMJD6 jumonji domain containing 6
KDM5B lysine (K)-specific demethylase 5B
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF5C kinesin family member 5C
KRT19 keratin 19, type I
LITAF lipopolysaccharide-induced TNF factor
LOC100272216 uncharacterized LOC100272216
LPAR6 lysophosphatidic acid receptor 6
MAGEA3 melanoma antigen family A3
MAGED1 melanoma antigen family D1
MAOA monoamine oxidase A
MAOB monoamine oxidase B
MBP myelin basic protein
NDRG1 N-myc downstream regulated 1
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NME4 NME/NM23 nucleoside diphosphate kinase 4
OBSL1 obscurin-like 1
OXTR oxytocin receptor
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PBK PDZ binding kinase
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
PDE10A phosphodiesterase 10A
PGK1 phosphoglycerate kinase 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLK1 polo-like kinase 1
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
QPRT quinolinate phosphoribosyltransferase
RAD21 RAD21 homolog (S. pombe)
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RNF44 ring finger protein 44
RPL31 ribosomal protein L31
SCUBE2 signal peptide, CUB domain, EGF-like 2
SELE selectin E
SEPP1 selenoprotein P, plasma, 1
SIK1 salt-inducible kinase 1
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SMAD3 SMAD family member 3
SMS spermine synthase
SOD2 superoxide dismutase 2, mitochondrial
SPP1 secreted phosphoprotein 1
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SST somatostatin
STC1 stanniocalcin 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
STK26 serine/threonine protein kinase 26
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TMEM45A transmembrane protein 45A
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNNT1 troponin T type 1 (skeletal, slow)
TOP2A topoisomerase (DNA) II alpha 170kDa
TOX3 TOX high mobility group box family member 3
TPBG trophoblast glycoprotein
TRPS1 trichorhinophalangeal syndrome I
TSPYL5 TSPY-like 5
TUSC3 tumor suppressor candidate 3
UBE2C ubiquitin-conjugating enzyme E2C
USP3 ubiquitin specific peptidase 3
XIST X inactive specific transcript (non-protein coding)
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
YPEL5 yippee-like 5 (Drosophila)
ZNF292 zinc finger protein 292
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain
ADAM12 ADAM metallopeptidase domain 12
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMDHD2 amidohydrolase domain containing 2
AREG amphiregulin
ARL4C ADP-ribosylation factor-like 4C
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ASPH aspartate beta-hydroxylase
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BEX1 brain expressed, X-linked 1
BGN biglycan
BHLHE41 basic helix-loop-helix family, member e41
C2CD5 C2 calcium-dependent domain containing 5
CALML5 calmodulin-like 5
CD36 CD36 molecule (thrombospondin receptor)
CD47 CD47 molecule
CD59 CD59 molecule, complement regulatory protein
CDC45 cell division cycle 45
CDC7 cell division cycle 7
CDKN2A cyclin-dependent kinase inhibitor 2A
CENPU centromere protein U
CFI complement factor I
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
COMP cartilage oligomeric matrix protein
CXCL12 chemokine (C-X-C motif) ligand 12
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYTH1 cytohesin 1
DACT1 dishevelled-binding antagonist of beta-catenin 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DEPTOR DEP domain containing MTOR-interacting protein
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLC1 DLC1 Rho GTPase activating protein
DLD dihydrolipoamide dehydrogenase
DLX2 distal-less homeobox 2
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUT deoxyuridine triphosphatase
ECM1 extracellular matrix protein 1
EGR3 early growth response 3
EIF5A eukaryotic translation initiation factor 5A
ELOVL1 ELOVL fatty acid elongase 1
EMP1 epithelial membrane protein 1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EREG epiregulin
ETNK1 ethanolamine kinase 1
ETV1 ets variant 1
F3 coagulation factor III (thromboplastin, tissue factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM129A family with sequence similarity 129, member A
FBN1 fibrillin 1
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
FOSL1 FOS-like antigen 1
GEM GTP binding protein overexpressed in skeletal muscle
GINS1 GINS complex subunit 1 (Psf1 homolog)
GREM1 gremlin 1, DAN family BMP antagonist
GSTP1 glutathione S-transferase pi 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
GUSB glucuronidase, beta
H1F0 H1 histone family, member 0
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGA2 high mobility group AT-hook 2
HOPX HOP homeobox
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFRD2 interferon-related developmental regulator 2
INHBA inhibin, beta A
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
JUN jun proto-oncogene
KCTD3 potassium channel tetramerization domain containing 3
KLF4 Kruppel-like factor 4 (gut)
KRT6B keratin 6B, type II
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIG1 ligase I, DNA, ATP-dependent
LMCD1 LIM and cysteine-rich domains 1
LMNA lamin A/C
LRRC17 leucine rich repeat containing 17
LRRN3 leucine rich repeat neuronal 3
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAN1A1 mannosidase, alpha, class 1A, member 1
MCL1 myeloid cell leukemia 1
MCM2 minichromosome maintenance complex component 2
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MET MET proto-oncogene, receptor tyrosine kinase
MRPL57 mitochondrial ribosomal protein L57
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NOP56 NOP56 ribonucleoprotein
NOV nephroblastoma overexpressed
NREP neuronal regeneration related protein
NT5DC2 5'-nucleotidase domain containing 2
NTM neurotrimin
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NXT1 nuclear transport factor 2-like export factor 1
PBX1 pre-B-cell leukemia homeobox 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCNA proliferating cell nuclear antigen
PDGFD platelet derived growth factor D
PDLIM3 PDZ and LIM domain 3
PEX11A peroxisomal biogenesis factor 11 alpha
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PHYH phytanoyl-CoA 2-hydroxylase
PLN phospholamban
PLS3 plastin 3
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRSS2 protease, serine, 2 (trypsin 2)
PRSS3 protease, serine, 3
PTN pleiotrophin
PTPRD protein tyrosine phosphatase, receptor type, D
PYROXD1 pyridine nucleotide-disulphide oxidoreductase domain 1
RAD51C RAD51 paralog C
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RBP1 retinol binding protein 1, cellular
RECQL RecQ helicase-like
RFC2 replication factor C (activator 1) 2, 40kDa
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
S100A7 S100 calcium binding protein A7
S100P S100 calcium binding protein P
SCG5 secretogranin V
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC16A6 solute carrier family 16, member 6
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SOX9 SRY (sex determining region Y)-box 9
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SRPX sushi-repeat containing protein, X-linked
SRSF1 serine/arginine-rich splicing factor 1
SRSF2 serine/arginine-rich splicing factor 2
STK38L serine/threonine kinase 38 like
STX1A syntaxin 1A (brain)
SULF1 sulfatase 1
THBD thrombomodulin
THBS1 thrombospondin 1
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM230 transmembrane protein 230
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
UNG uracil-DNA glycosylase
USP1 ubiquitin specific peptidase 1
VEGFC vascular endothelial growth factor C
VSNL1 visinin-like 1
ZWINT ZW10 interacting kinetochore protein