BRD-A19500257_geldanamycin_HME1_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

108 genes differentially expressed following the BRD-A19500257_geldanamycin_HME1_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMCX1 armadillo repeat containing, X-linked 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
BAG3 BCL2-associated athanogene 3
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CD24 CD24 molecule
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL5 chemokine (C-X-C motif) ligand 5
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDIT3 DNA-damage-inducible transcript 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EFNB2 ephrin-B2
EMX2 empty spiracles homeobox 2
FAM13A family with sequence similarity 13, member A
FKBP14 FK506 binding protein 14, 22 kDa
FOLR1 folate receptor 1 (adult)
FXYD2 FXYD domain containing ion transport regulator 2
G0S2 G0/G1 switch 2
GARS glycyl-tRNA synthetase
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
HYOU1 hypoxia up-regulated 1
ICAM1 intercellular adhesion molecule 1
IFRD1 interferon-related developmental regulator 1
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
LIMCH1 LIM and calponin homology domains 1
MANF mesencephalic astrocyte-derived neurotrophic factor
MARCKS myristoylated alanine-rich protein kinase C substrate
MGLL monoglyceride lipase
NOVA1 neuro-oncological ventral antigen 1
NUPR1 nuclear protein, transcriptional regulator, 1
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
PAN2 PAN2 poly(A) specific ribonuclease subunit
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDE4DIP phosphodiesterase 4D interacting protein
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAT1 phosphoserine aminotransferase 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAD9A RAD9 homolog A (S. pombe)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
SDF2L1 stromal cell-derived factor 2-like 1
SEC24D SEC24 family member D
SEC31A SEC31 homolog A (S. cerevisiae)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERP1 stress-associated endoplasmic reticulum protein 1
SLC16A4 solute carrier family 16, member 4
SLC35B1 solute carrier family 35, member B1
SLC38A1 solute carrier family 38, member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SUCO SUN domain containing ossification factor
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TRA2A transformer 2 alpha homolog (Drosophila)
TRIB3 tribbles pseudokinase 3
UGDH UDP-glucose 6-dehydrogenase
WBP5 WW domain binding protein 5
XBP1 X-box binding protein 1

decreased expression

Symbol Name
AREG amphiregulin
CCND2 cyclin D2
CFI complement factor I
CYR61 cysteine-rich, angiogenic inducer, 61
DMD dystrophin
EGR3 early growth response 3
FGFR3 fibroblast growth factor receptor 3
FKBP5 FK506 binding protein 5
GJA1 gap junction protein, alpha 1, 43kDa
GSTM3 glutathione S-transferase mu 3 (brain)
HBB hemoglobin, beta
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL32 interleukin 32
JADE2 jade family PHD finger 2
LEF1 lymphoid enhancer-binding factor 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
PDGFA platelet-derived growth factor alpha polypeptide
PFN2 profilin 2
PRDX2 peroxiredoxin 2
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
RGS2 regulator of G-protein signaling 2
RNH1 ribonuclease/angiogenin inhibitor 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A10 S100 calcium binding protein A10
STAR steroidogenic acute regulatory protein
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNC tenascin C
WEE1 WEE1 G2 checkpoint kinase
ZFP36L2 ZFP36 ring finger protein-like 2