BRD-A19500257_geldanamycin_HME1_3_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

122 genes differentially expressed following the BRD-A19500257_geldanamycin_HME1_3_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3
ARHGAP29 Rho GTPase activating protein 29
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
BAG3 BCL2-associated athanogene 3
BCL2A1 BCL2-related protein A1
CBS cystathionine-beta-synthase
CDK2AP2 cyclin-dependent kinase 2 associated protein 2
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CNPY3 canopy FGF signaling regulator 3
COBLL1 cordon-bleu WH2 repeat protein-like 1
COL3A1 collagen, type III, alpha 1
CREB3L2 cAMP responsive element binding protein 3-like 2
CRELD2 cysteine-rich with EGF-like domains 2
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CTH cystathionine gamma-lyase
DDIT3 DNA-damage-inducible transcript 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DST dystonin
EFNB2 ephrin-B2
EPAS1 endothelial PAS domain protein 1
FOXF1 forkhead box F1
GARS glycyl-tRNA synthetase
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
HYOU1 hypoxia up-regulated 1
INHBE inhibin, beta E
JCHAIN joining chain of multimeric IgA and IgM
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
LIMCH1 LIM and calponin homology domains 1
MAGT1 magnesium transporter 1
MANF mesencephalic astrocyte-derived neurotrophic factor
MET MET proto-oncogene, receptor tyrosine kinase
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUPR1 nuclear protein, transcriptional regulator, 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCSK1 proprotein convertase subtilisin/kexin type 1
PDE4DIP phosphodiesterase 4D interacting protein
PDIA3 protein disulfide isomerase family A, member 3
PDIA4 protein disulfide isomerase family A, member 4
PLD3 phospholipase D family, member 3
PMP22 peripheral myelin protein 22
PPAP2B phosphatidic acid phosphatase type 2B
PPIB peptidylprolyl isomerase B (cyclophilin B)
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAD9A RAD9 homolog A (S. pombe)
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RPL10 ribosomal protein L10
SATB1 SATB homeobox 1
SDF2L1 stromal cell-derived factor 2-like 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SOS1 son of sevenless homolog 1 (Drosophila)
TARS threonyl-tRNA synthetase
TES testin LIM domain protein
TNNC1 troponin C type 1 (slow)
TPBG trophoblast glycoprotein
TTN titin
UGDH UDP-glucose 6-dehydrogenase
USP6NL USP6 N-terminal like
WARS tryptophanyl-tRNA synthetase
WSB1 WD repeat and SOCS box containing 1

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AREG amphiregulin
CA12 carbonic anhydrase XII
CANT1 calcium activated nucleotidase 1
CFD complement factor D (adipsin)
CST1 cystatin SN
CXCL12 chemokine (C-X-C motif) ligand 12
CXCR4 chemokine (C-X-C motif) receptor 4
DEPTOR DEP domain containing MTOR-interacting protein
DHRS2 dehydrogenase/reductase (SDR family) member 2
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
F13A1 coagulation factor XIII, A1 polypeptide
F5 coagulation factor V (proaccelerin, labile factor)
FABP4 fatty acid binding protein 4, adipocyte
FAM60A family with sequence similarity 60, member A
GAL galanin/GMAP prepropeptide
HN1 hematological and neurological expressed 1
HOXC6 homeobox C6
HP haptoglobin
IER3 immediate early response 3
IFI30 interferon, gamma-inducible protein 30
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS4 lectin, galactoside-binding, soluble, 4
MMD monocyte to macrophage differentiation-associated
NPTX2 neuronal pentraxin II
OLFM4 olfactomedin 4
PI3 peptidase inhibitor 3, skin-derived
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RBP1 retinol binding protein 1, cellular
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
S100A8 S100 calcium binding protein A8
SCGB2A2 secretoglobin, family 2A, member 2
SDC1 syndecan 1
SNAI2 snail family zinc finger 2
SPP1 secreted phosphoprotein 1
SRPX sushi-repeat containing protein, X-linked
STEAP1 six transmembrane epithelial antigen of the prostate 1
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TSC22D3 TSC22 domain family, member 3
TYRP1 tyrosinase-related protein 1