BRD-A19500257_geldanamycin_HME1_3_h_0.12_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

90 genes differentially expressed following the BRD-A19500257_geldanamycin_HME1_3_h_0.12_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AQP3 aquaporin 3 (Gill blood group)
ARG1 arginase 1
ARHGAP29 Rho GTPase activating protein 29
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
BAG3 BCL2-associated athanogene 3
BCAT1 branched chain amino-acid transaminase 1, cytosolic
CBS cystathionine-beta-synthase
CDK2AP2 cyclin-dependent kinase 2 associated protein 2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLGN calmegin
DDIT3 DNA-damage-inducible transcript 3
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
FOLR1 folate receptor 1 (adult)
GLRX glutaredoxin (thioltransferase)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
HYOU1 hypoxia up-regulated 1
IGKC immunoglobulin kappa constant
IGKV4-1 immunoglobulin kappa variable 4-1
KCTD12 potassium channel tetramerization domain containing 12
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
LAMP3 lysosomal-associated membrane protein 3
LIMCH1 LIM and calponin homology domains 1
MANF mesencephalic astrocyte-derived neurotrophic factor
MLF1 myeloid leukemia factor 1
MSLN mesothelin
NCALD neurocalcin delta
ODC1 ornithine decarboxylase 1
PRAME preferentially expressed antigen in melanoma
RAD9A RAD9 homolog A (S. pombe)
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNX11 sorting nexin 11
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
TARP TCR gamma alternate reading frame protein
TRIB3 tribbles pseudokinase 3
TTC3 tetratricopeptide repeat domain 3
WIF1 WNT inhibitory factor 1

decreased expression

Symbol Name
ANPEP alanyl (membrane) aminopeptidase
AOX1 aldehyde oxidase 1
AREG amphiregulin
CCND2 cyclin D2
CDCA4 cell division cycle associated 4
CDKN2A cyclin-dependent kinase inhibitor 2A
CRABP2 cellular retinoic acid binding protein 2
DEPTOR DEP domain containing MTOR-interacting protein
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUOX2 dual oxidase 2
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
GLUL glutamate-ammonia ligase
HK2 hexokinase 2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IGFBP6 insulin-like growth factor binding protein 6
KRT15 keratin 15, type I
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
MT1H metallothionein 1H
NID2 nidogen 2 (osteonidogen)
NPY1R neuropeptide Y receptor Y1
PBX1 pre-B-cell leukemia homeobox 1
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PDZK1IP1 PDZK1 interacting protein 1
PEX11A peroxisomal biogenesis factor 11 alpha
PHLDA1 pleckstrin homology-like domain, family A, member 1
PI3 peptidase inhibitor 3, skin-derived
RAMP1 receptor (G protein-coupled) activity modifying protein 1
S100A14 S100 calcium binding protein A14
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SPRR1B small proline-rich protein 1B
SRPX sushi-repeat containing protein, X-linked
TFF1 trefoil factor 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TSC22D3 TSC22 domain family, member 3
VCAN versican
VSNL1 visinin-like 1