BRD-A19500257_geldanamycin_HME1_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

333 genes differentially expressed following the BRD-A19500257_geldanamycin_HME1_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABHD4 abhydrolase domain containing 4
ACKR3 atypical chemokine receptor 3
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTG2 actin, gamma 2, smooth muscle, enteric
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADCY9 adenylate cyclase 9
ALCAM activated leukocyte cell adhesion molecule
ARID5B AT rich interactive domain 5B (MRF1-like)
ASCL1 achaete-scute family bHLH transcription factor 1
ATP9A ATPase, class II, type 9A
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BLNK B-cell linker
C6ORF48 chromosome 6 open reading frame 48
C9ORF3 chromosome 9 open reading frame 3
CALCOCO1 calcium binding and coiled-coil domain 1
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNG1 cyclin G1
CCNG2 cyclin G2
CD58 CD58 molecule
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDK19 cyclin-dependent kinase 19
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLN3 ceroid-lipofuscinosis, neuronal 3
CLU clusterin
CNN1 calponin 1, basic, smooth muscle
COL3A1 collagen, type III, alpha 1
CREG1 cellular repressor of E1A-stimulated genes 1
CRYAB crystallin, alpha B
DEFB1 defensin, beta 1
DES desmin
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DSG2 desmoglein 2
EFNA1 ephrin-A1
EIF3F eukaryotic translation initiation factor 3, subunit F
EIF3L eukaryotic translation initiation factor 3, subunit L
EIF4B eukaryotic translation initiation factor 4B
FAM134A family with sequence similarity 134, member A
FAM13B family with sequence similarity 13, member B
FAXDC2 fatty acid hydroxylase domain containing 2
FBLN1 fibulin 1
FOXO4 forkhead box O4
FTH1 ferritin, heavy polypeptide 1
FXR1 fragile X mental retardation, autosomal homolog 1
GAB2 GRB2-associated binding protein 2
GABARAPL1 GABA(A) receptor-associated protein like 1
GAS1 growth arrest-specific 1
GBP2 guanylate binding protein 2, interferon-inducible
GLUL glutamate-ammonia ligase
GOLGB1 golgin B1
GOLPH3L golgi phosphoprotein 3-like
GPC1 glypican 1
GPNMB glycoprotein (transmembrane) nmb
GPX3 glutathione peroxidase 3
GRN granulin
HBP1 HMG-box transcription factor 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMOX1 heme oxygenase 1
HOXA5 homeobox A5
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
HSPB8 heat shock 22kDa protein 8
IGBP1 immunoglobulin (CD79A) binding protein 1
IGFBP3 insulin-like growth factor binding protein 3
IL15 interleukin 15
KIAA0930 KIAA0930
KIZ kizuna centrosomal protein
KLHL24 kelch-like family member 24
KRT13 keratin 13, type I
KRT17 keratin 17, type I
LAMB2 laminin, beta 2 (laminin S)
LAMP2 lysosomal-associated membrane protein 2
LAPTM4A lysosomal protein transmembrane 4 alpha
LITAF lipopolysaccharide-induced TNF factor
LMOD1 leiomodin 1 (smooth muscle)
MAGED2 melanoma antigen family D2
MATN2 matrilin 2
MEIS2 Meis homeobox 2
METTL7A methyltransferase like 7A
MKRN1 makorin ring finger protein 1
MN1 meningioma (disrupted in balanced translocation) 1
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
MYL9 myosin, light chain 9, regulatory
MYLK myosin light chain kinase
N4BP2L1 NEDD4 binding protein 2-like 1
NAV2 neuron navigator 2
NBR1 neighbor of BRCA1 gene 1
NDRG1 N-myc downstream regulated 1
NUMA1 nuclear mitotic apparatus protein 1
NUPR1 nuclear protein, transcriptional regulator, 1
NXN nucleoredoxin
OFD1 oral-facial-digital syndrome 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
ORAI3 ORAI calcium release-activated calcium modulator 3
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin
OSER1 oxidative stress responsive serine-rich 1
OSR2 odd-skipped related transciption factor 2
P3H2 prolyl 3-hydroxylase 2
PALLD palladin, cytoskeletal associated protein
PBX1 pre-B-cell leukemia homeobox 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDLIM1 PDZ and LIM domain 1
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLCB4 phospholipase C, beta 4
PLXNB2 plexin B2
PNRC1 proline-rich nuclear receptor coactivator 1
PPL periplakin
PRUNE2 prune homolog 2 (Drosophila)
PSAP prosaposin
PTGIS prostaglandin I2 (prostacyclin) synthase
PTN pleiotrophin
QPRT quinolinate phosphoribosyltransferase
RABGAP1L RAB GTPase activating protein 1-like
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RB1CC1 RB1-inducible coiled-coil 1
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RPL28 ribosomal protein L28
RPL31 ribosomal protein L31
SARAF store-operated calcium entry-associated regulatory factor
SC5D sterol-C5-desaturase
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPP1 selenoprotein P, plasma, 1
SERINC5 serine incorporator 5
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SFN stratifin
SFRP4 secreted frizzled-related protein 4
SH3BGRL SH3 domain binding glutamate-rich protein like
SIDT2 SID1 transmembrane family, member 2
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SNCAIP synuclein, alpha interacting protein
SOX4 SRY (sex determining region Y)-box 4
SPATA20 spermatogenesis associated 20
SPON2 spondin 2, extracellular matrix protein
SQSTM1 sequestosome 1
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
ST5 suppression of tumorigenicity 5
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STK38 serine/threonine kinase 38
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SYNE2 spectrin repeat containing, nuclear envelope 2
TAGLN transgelin
TMEM45A transmembrane protein 45A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOX thymocyte selection-associated high mobility group box
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
TPP1 tripeptidyl peptidase I
TTC28 tetratricopeptide repeat domain 28
TUFT1 tuftelin 1
UBA7 ubiquitin-like modifier activating enzyme 7
USP9X ubiquitin specific peptidase 9, X-linked
VAT1 vesicle amine transport 1
VAV3 vav 3 guanine nucleotide exchange factor
VNN1 vanin 1
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
WDR48 WD repeat domain 48
WDTC1 WD and tetratricopeptide repeats 1
WISP2 WNT1 inducible signaling pathway protein 2
YPEL5 yippee-like 5 (Drosophila)
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
AKAP12 A kinase (PRKA) anchor protein 12
ANGPTL4 angiopoietin-like 4
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ANPEP alanyl (membrane) aminopeptidase
AREG amphiregulin
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ASPH aspartate beta-hydroxylase
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BOP1 block of proliferation 1
C1QBP complement component 1, q subcomponent binding protein
CA2 carbonic anhydrase II
CBFB core-binding factor, beta subunit
CCND1 cyclin D1
CCND3 cyclin D3
CD36 CD36 molecule (thrombospondin receptor)
CD44 CD44 molecule (Indian blood group)
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CEP170 centrosomal protein 170kDa
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CKLF chemokine-like factor
COL10A1 collagen, type X, alpha 1
CTPS1 CTP synthase 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYTL1 cytokine-like 1
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DKC1 dyskeratosis congenita 1, dyskerin
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
DUT deoxyuridine triphosphatase
EEF1E1 eukaryotic translation elongation factor 1 epsilon 1
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMG1 EMG1 N1-specific pseudouridine methyltransferase
EMP1 epithelial membrane protein 1
ENO1 enolase 1, (alpha)
EREG epiregulin
ERO1L ERO1-like (S. cerevisiae)
ETV1 ets variant 1
ETV5 ets variant 5
EXOSC2 exosome component 2
F3 coagulation factor III (thromboplastin, tissue factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FAM216A family with sequence similarity 216, member A
FEN1 flap structure-specific endonuclease 1
FH fumarate hydratase
FOSL1 FOS-like antigen 1
FRZB frizzled-related protein
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLRX2 glutaredoxin 2
GNAS GNAS complex locus
GTPBP4 GTP binding protein 4
HBEGF heparin-binding EGF-like growth factor
HMGA2 high mobility group AT-hook 2
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
ICMT isoprenylcysteine carboxyl methyltransferase
IER3 immediate early response 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
INHBA inhibin, beta A
ITGA6 integrin, alpha 6
ITGB5 integrin, beta 5
JUN jun proto-oncogene
LPXN leupaxin
LTF lactotransferrin
MALL mal, T-cell differentiation protein-like
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MINA MYC induced nuclear antigen
MMD monocyte to macrophage differentiation-associated
MMP1 matrix metallopeptidase 1
MMP9 matrix metallopeptidase 9
MRPL12 mitochondrial ribosomal protein L12
MRPL15 mitochondrial ribosomal protein L15
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAE1 NEDD8 activating enzyme E1 subunit 1
NAMPT nicotinamide phosphoribosyltransferase
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NPM3 nucleophosmin/nucleoplasmin 3
NRGN neurogranin (protein kinase C substrate, RC3)
NRP1 neuropilin 1
NT5E 5'-nucleotidase, ecto (CD73)
NXT1 nuclear transport factor 2-like export factor 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PCNA proliferating cell nuclear antigen
PCOLCE2 procollagen C-endopeptidase enhancer 2
PDE4B phosphodiesterase 4B, cAMP-specific
PDGFA platelet-derived growth factor alpha polypeptide
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PLEK2 pleckstrin 2
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
POSTN periostin, osteoblast specific factor
PRMT1 protein arginine methyltransferase 1
PRSS2 protease, serine, 2 (trypsin 2)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTX3 pentraxin 3, long
PUS7 pseudouridylate synthase 7 (putative)
RAI14 retinoic acid induced 14
RANBP1 RAN binding protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFTN1 raftlin, lipid raft linker 1
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RRM2 ribonucleotide reductase M2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RUVBL1 RuvB-like AAA ATPase 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFTPB surfactant protein B
SIGMAR1 sigma non-opioid intracellular receptor 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SMAGP small cell adhesion glycoprotein
SMYD2 SET and MYND domain containing 2
SNAI2 snail family zinc finger 2
SNRPG small nuclear ribonucleoprotein polypeptide G
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SRM spermidine synthase
SRPX sushi-repeat containing protein, X-linked
SRSF7 serine/arginine-rich splicing factor 7
STC1 stanniocalcin 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
STX1A syntaxin 1A (brain)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TIPIN TIMELESS interacting protein
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM5 transmembrane protein 5
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRIP13 thyroid hormone receptor interactor 13
TUBG1 tubulin, gamma 1
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2E3 ubiquitin-conjugating enzyme E2E 3
UPP1 uridine phosphorylase 1
VCAN versican
ZWINT ZW10 interacting kinetochore protein