BRD-A19500257_geldanamycin_HME1_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

330 genes differentially expressed following the BRD-A19500257_geldanamycin_HME1_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABHD4 abhydrolase domain containing 4
ACKR3 atypical chemokine receptor 3
ACTG2 actin, gamma 2, smooth muscle, enteric
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADCY9 adenylate cyclase 9
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ANKRD36B ankyrin repeat domain 36B
ARID5B AT rich interactive domain 5B (MRF1-like)
ATP9A ATPase, class II, type 9A
BAG2 BCL2-associated athanogene 2
BPTF bromodomain PHD finger transcription factor
BTN3A1 butyrophilin, subfamily 3, member A1
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
C9ORF3 chromosome 9 open reading frame 3
CADM1 cell adhesion molecule 1
CALCOCO1 calcium binding and coiled-coil domain 1
CALHM2 calcium homeostasis modulator 2
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CD58 CD58 molecule
CDK19 cyclin-dependent kinase 19
CFB complement factor B
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLEC3B C-type lectin domain family 3, member B
CLN3 ceroid-lipofuscinosis, neuronal 3
CLU clusterin
COL21A1 collagen, type XXI, alpha 1
CREG1 cellular repressor of E1A-stimulated genes 1
CRELD2 cysteine-rich with EGF-like domains 2
CRYAB crystallin, alpha B
CTBP2 C-terminal binding protein 2
CTSA cathepsin A
CXCL13 chemokine (C-X-C motif) ligand 13
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DAPK1 death-associated protein kinase 1
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DEFB1 defensin, beta 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DSTN destrin (actin depolymerizing factor)
ECHDC2 enoyl CoA hydratase domain containing 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FADS1 fatty acid desaturase 1
FAM117A family with sequence similarity 117, member A
FAM134A family with sequence similarity 134, member A
FAM13B family with sequence similarity 13, member B
FAXDC2 fatty acid hydroxylase domain containing 2
FBLN1 fibulin 1
FNBP1 formin binding protein 1
FOXO4 forkhead box O4
FTH1 ferritin, heavy polypeptide 1
FXR1 fragile X mental retardation, autosomal homolog 1
GAB2 GRB2-associated binding protein 2
GABARAPL1 GABA(A) receptor-associated protein like 1
GBP2 guanylate binding protein 2, interferon-inducible
GLUL glutamate-ammonia ligase
GNS glucosamine (N-acetyl)-6-sulfatase
GPC1 glypican 1
GPNMB glycoprotein (transmembrane) nmb
GPR88 G protein-coupled receptor 88
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HOXA5 homeobox A5
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPA1A heat shock 70kDa protein 1A
HSPA4L heat shock 70kDa protein 4-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
ICAM2 intercellular adhesion molecule 2
IDS iduronate 2-sulfatase
IGKV1-5 immunoglobulin kappa variable 1-5
IL2RB interleukin 2 receptor, beta
ITGAV integrin, alpha V
KLHL24 kelch-like family member 24
KRT13 keratin 13, type I
KRT16 keratin 16, type I
KRT6A keratin 6A, type II
LAMP2 lysosomal-associated membrane protein 2
MAN1A1 mannosidase, alpha, class 1A, member 1
MAN2A2 mannosidase, alpha, class 2A, member 2
MATN2 matrilin 2
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MEIS1 Meis homeobox 1
MEIS2 Meis homeobox 2
MINK1 misshapen-like kinase 1
MSMO1 methylsterol monooxygenase 1
MYL9 myosin, light chain 9, regulatory
N4BP2L1 NEDD4 binding protein 2-like 1
NEU1 sialidase 1 (lysosomal sialidase)
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9
NUPR1 nuclear protein, transcriptional regulator, 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OSR2 odd-skipped related transciption factor 2
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
PERP PERP, TP53 apoptosis effector
PHF1 PHD finger protein 1
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PIR pirin (iron-binding nuclear protein)
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
PLBD1 phospholipase B domain containing 1
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLK2 polo-like kinase 2
PLXNB2 plexin B2
PPAP2B phosphatidic acid phosphatase type 2B
PRUNE2 prune homolog 2 (Drosophila)
PSAP prosaposin
QPRT quinolinate phosphoribosyltransferase
RABGAP1L RAB GTPase activating protein 1-like
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RB1CC1 RB1-inducible coiled-coil 1
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RHCG Rh family, C glycoprotein
RTN3 reticulon 3
S100A4 S100 calcium binding protein A4
SDCBP syndecan binding protein (syntenin)
SEPP1 selenoprotein P, plasma, 1
SERINC3 serine incorporator 3
SERINC5 serine incorporator 5
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SFN stratifin
SH3BGRL SH3 domain binding glutamate-rich protein like
SIDT2 SID1 transmembrane family, member 2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SNCAIP synuclein, alpha interacting protein
SPON2 spondin 2, extracellular matrix protein
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SQLE squalene epoxidase
SQSTM1 sequestosome 1
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
ST5 suppression of tumorigenicity 5
STK38 serine/threonine kinase 38
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TAGLN transgelin
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TLE4 transducin-like enhancer of split 4
TMEM35 transmembrane protein 35
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOX thymocyte selection-associated high mobility group box
TPP1 tripeptidyl peptidase I
TPST2 tyrosylprotein sulfotransferase 2
TTC28 tetratricopeptide repeat domain 28
TUBA1A tubulin, alpha 1a
TXNRD1 thioredoxin reductase 1
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UGDH UDP-glucose 6-dehydrogenase
VAV3 vav 3 guanine nucleotide exchange factor
VNN1 vanin 1
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
WDTC1 WD and tetratricopeptide repeats 1
WISP2 WNT1 inducible signaling pathway protein 2
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF91 zinc finger protein 91
ZSCAN31 zinc finger and SCAN domain containing 31

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANGPTL4 angiopoietin-like 4
AREG amphiregulin
ASPH aspartate beta-hydroxylase
BHLHE41 basic helix-loop-helix family, member e41
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
C1QBP complement component 1, q subcomponent binding protein
C3ORF14 chromosome 3 open reading frame 14
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CBFB core-binding factor, beta subunit
CCND1 cyclin D1
CCND3 cyclin D3
CD36 CD36 molecule (thrombospondin receptor)
CDCA4 cell division cycle associated 4
CKS1B CDC28 protein kinase regulatory subunit 1B
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYTL1 cytokine-like 1
DCLK1 doublecortin-like kinase 1
DKC1 dyskeratosis congenita 1, dyskerin
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
DUT deoxyuridine triphosphatase
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMP1 epithelial membrane protein 1
ENO1 enolase 1, (alpha)
EPHA2 EPH receptor A2
EREG epiregulin
ETV1 ets variant 1
ETV5 ets variant 5
EXOSC2 exosome component 2
F3 coagulation factor III (thromboplastin, tissue factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM216A family with sequence similarity 216, member A
FEN1 flap structure-specific endonuclease 1
FHL1 four and a half LIM domains 1
FOSL1 FOS-like antigen 1
FRZB frizzled-related protein
FTSJ1 FtsJ RNA methyltransferase homolog 1 (E. coli)
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
GINS2 GINS complex subunit 2 (Psf2 homolog)
GNAS GNAS complex locus
GRB7 growth factor receptor-bound protein 7
GRIA2 glutamate receptor, ionotropic, AMPA 2
GTPBP4 GTP binding protein 4
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HMGA1 high mobility group AT-hook 1
HMGA2 high mobility group AT-hook 2
HMGN1 high mobility group nucleosome binding domain 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFRD2 interferon-related developmental regulator 2
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL1B interleukin 1, beta
IL1RAP interleukin 1 receptor accessory protein
INHBA inhibin, beta A
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
ITGB5 integrin, beta 5
KLF9 Kruppel-like factor 9
LIG1 ligase I, DNA, ATP-dependent
LOXL2 lysyl oxidase-like 2
LTF lactotransferrin
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MELK maternal embryonic leucine zipper kinase
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMP9 matrix metallopeptidase 9
MRPL15 mitochondrial ribosomal protein L15
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NRN1 neuritin 1
NT5E 5'-nucleotidase, ecto (CD73)
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PCSK1 proprotein convertase subtilisin/kexin type 1
PDE4B phosphodiesterase 4B, cAMP-specific
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PFKP phosphofructokinase, platelet
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PNP purine nucleoside phosphorylase
POSTN periostin, osteoblast specific factor
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRKCH protein kinase C, eta
PRKD3 protein kinase D3
PRMT1 protein arginine methyltransferase 1
PRSS2 protease, serine, 2 (trypsin 2)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PUS7 pseudouridylate synthase 7 (putative)
PXMP2 peroxisomal membrane protein 2, 22kDa
RANBP1 RAN binding protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFTN1 raftlin, lipid raft linker 1
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPA3 replication protein A3, 14kDa
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RTN1 reticulon 1
RUVBL1 RuvB-like AAA ATPase 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SH2B3 SH2B adaptor protein 3
SLBP stem-loop binding protein
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLIRP SRA stem-loop interacting RNA binding protein
SNAI2 snail family zinc finger 2
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SRI sorcin
SRM spermidine synthase
SRPX sushi-repeat containing protein, X-linked
STC1 stanniocalcin 1
STX1A syntaxin 1A (brain)
TACC3 transforming, acidic coiled-coil containing protein 3
TAGLN2 transgelin 2
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFF1 trefoil factor 1
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF1 transmembrane 4 L six family member 1
TNC tenascin C
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRAPPC4 trafficking protein particle complex 4
TRIP13 thyroid hormone receptor interactor 13
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
VCAN versican
ZBTB16 zinc finger and BTB domain containing 16
ZWINT ZW10 interacting kinetochore protein