BRD-A19500257_geldanamycin_HME1_24_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

318 genes differentially expressed following the BRD-A19500257_geldanamycin_HME1_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABHD4 abhydrolase domain containing 4
ACKR3 atypical chemokine receptor 3
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTG2 actin, gamma 2, smooth muscle, enteric
ADD3 adducin 3 (gamma)
ARID5B AT rich interactive domain 5B (MRF1-like)
ATP5G2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
ATP9A ATPase, class II, type 9A
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BBS1 Bardet-Biedl syndrome 1
BRD8 bromodomain containing 8
BSG basigin (Ok blood group)
C6ORF48 chromosome 6 open reading frame 48
C9ORF3 chromosome 9 open reading frame 3
CADM1 cell adhesion molecule 1
CALCOCO1 calcium binding and coiled-coil domain 1
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CBR3 carbonyl reductase 3
CCDC28A coiled-coil domain containing 28A
CCNG1 cyclin G1
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDK19 cyclin-dependent kinase 19
CLN3 ceroid-lipofuscinosis, neuronal 3
CLU clusterin
CNN1 calponin 1, basic, smooth muscle
COCH cochlin
COL2A1 collagen, type II, alpha 1
COL3A1 collagen, type III, alpha 1
COL4A5 collagen, type IV, alpha 5
CRYAB crystallin, alpha B
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
DAPK1 death-associated protein kinase 1
DCN decorin
DEPTOR DEP domain containing MTOR-interacting protein
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DSG2 desmoglein 2
DSP desmoplakin
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFHC1 EF-hand domain (C-terminal) containing 1
EGFR epidermal growth factor receptor
EIF3F eukaryotic translation initiation factor 3, subunit F
FAM117A family with sequence similarity 117, member A
FAM13B family with sequence similarity 13, member B
FAXDC2 fatty acid hydroxylase domain containing 2
FBLN1 fibulin 1
FHL1 four and a half LIM domains 1
FNBP1 formin binding protein 1
FOXO4 forkhead box O4
FTH1 ferritin, heavy polypeptide 1
FXR1 fragile X mental retardation, autosomal homolog 1
GAB2 GRB2-associated binding protein 2
GABARAPL1 GABA(A) receptor-associated protein like 1
GAS1 growth arrest-specific 1
GLS glutaminase
GLUL glutamate-ammonia ligase
GOLGB1 golgin B1
GPNMB glycoprotein (transmembrane) nmb
GPX3 glutathione peroxidase 3
GRN granulin
HBP1 HMG-box transcription factor 1
HECA headcase homolog (Drosophila)
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HOXA5 homeobox A5
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPA1A heat shock 70kDa protein 1A
HSPA4L heat shock 70kDa protein 4-like
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
HSPB8 heat shock 22kDa protein 8
IGBP1 immunoglobulin (CD79A) binding protein 1
IGF1R insulin-like growth factor 1 receptor
IGFBP3 insulin-like growth factor binding protein 3
ITGAV integrin, alpha V
KIZ kizuna centrosomal protein
KRT14 keratin 14, type I
KRT17 keratin 17, type I
LAMB2 laminin, beta 2 (laminin S)
LETMD1 LETM1 domain containing 1
LITAF lipopolysaccharide-induced TNF factor
LMOD1 leiomodin 1 (smooth muscle)
LRRC1 leucine rich repeat containing 1
MAGED2 melanoma antigen family D2
MATN2 matrilin 2
MEIS2 Meis homeobox 2
METTL7A methyltransferase like 7A
MID1 midline 1
MINK1 misshapen-like kinase 1
MN1 meningioma (disrupted in balanced translocation) 1
MXI1 MAX interactor 1, dimerization protein
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
MYL9 myosin, light chain 9, regulatory
MYLK myosin light chain kinase
N4BP2L1 NEDD4 binding protein 2-like 1
NBR1 neighbor of BRCA1 gene 1
NUMA1 nuclear mitotic apparatus protein 1
NUPR1 nuclear protein, transcriptional regulator, 1
OFD1 oral-facial-digital syndrome 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OPTN optineurin
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin
OXTR oxytocin receptor
P3H2 prolyl 3-hydroxylase 2
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PALLD palladin, cytoskeletal associated protein
PBX1 pre-B-cell leukemia homeobox 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFC platelet derived growth factor C
PDLIM1 PDZ and LIM domain 1
PERP PERP, TP53 apoptosis effector
PHF1 PHD finger protein 1
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
PLCB4 phospholipase C, beta 4
PLXNB2 plexin B2
PNRC1 proline-rich nuclear receptor coactivator 1
PROM1 prominin 1
PRUNE2 prune homolog 2 (Drosophila)
PSAP prosaposin
QPRT quinolinate phosphoribosyltransferase
RABGAP1L RAB GTPase activating protein 1-like
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RELN reelin
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RIOK3 RIO kinase 3
RPL31 ribosomal protein L31
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SH3BGRL SH3 domain binding glutamate-rich protein like
SIDT2 SID1 transmembrane family, member 2
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SOX4 SRY (sex determining region Y)-box 4
SQSTM1 sequestosome 1
SSBP2 single-stranded DNA binding protein 2
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SYF2 SYF2 pre-mRNA-splicing factor
TAGLN transgelin
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
TIMP2 TIMP metallopeptidase inhibitor 2
TMEM45A transmembrane protein 45A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOX thymocyte selection-associated high mobility group box
TPM1 tropomyosin 1 (alpha)
TPP1 tripeptidyl peptidase I
TTC28 tetratricopeptide repeat domain 28
TTC3 tetratricopeptide repeat domain 3
TUFT1 tuftelin 1
TUSC3 tumor suppressor candidate 3
UBA7 ubiquitin-like modifier activating enzyme 7
UBE4B ubiquitination factor E4B
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
USP9X ubiquitin specific peptidase 9, X-linked
VNN1 vanin 1
VPS13B vacuolar protein sorting 13 homolog B (yeast)
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
WDTC1 WD and tetratricopeptide repeats 1
YPEL5 yippee-like 5 (Drosophila)
ZMIZ1 zinc finger, MIZ-type containing 1

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ACSL1 acyl-CoA synthetase long-chain family member 1
AGTR1 angiotensin II receptor, type 1
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AREG amphiregulin
ASPH aspartate beta-hydroxylase
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
C1QBP complement component 1, q subcomponent binding protein
C3ORF14 chromosome 3 open reading frame 14
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CBFB core-binding factor, beta subunit
CCND1 cyclin D1
CCND3 cyclin D3
CD36 CD36 molecule (thrombospondin receptor)
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CEP170 centrosomal protein 170kDa
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
COL10A1 collagen, type X, alpha 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DKC1 dyskeratosis congenita 1, dyskerin
DKK1 dickkopf WNT signaling pathway inhibitor 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EBP emopamil binding protein (sterol isomerase)
EEF1E1 eukaryotic translation elongation factor 1 epsilon 1
EGR3 early growth response 3
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
EIF4E eukaryotic translation initiation factor 4E
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMG1 EMG1 N1-specific pseudouridine methyltransferase
EMP1 epithelial membrane protein 1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPHA2 EPH receptor A2
EREG epiregulin
ETV1 ets variant 1
ETV5 ets variant 5
EXOSC2 exosome component 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
FTSJ1 FtsJ RNA methyltransferase homolog 1 (E. coli)
G0S2 G0/G1 switch 2
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
HAS2 hyaluronan synthase 2
HMGA1 high mobility group AT-hook 1
HMGA2 high mobility group AT-hook 2
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
ICMT isoprenylcysteine carboxyl methyltransferase
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFRD2 interferon-related developmental regulator 2
IL1B interleukin 1, beta
ITGB5 integrin, beta 5
JUN jun proto-oncogene
LPXN leupaxin
MALL mal, T-cell differentiation protein-like
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MCL1 myeloid cell leukemia 1
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MLPH melanophilin
MMD monocyte to macrophage differentiation-associated
MMP1 matrix metallopeptidase 1
MRPL15 mitochondrial ribosomal protein L15
MRPS16 mitochondrial ribosomal protein S16
MSX1 msh homeobox 1
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAV3 neuron navigator 3
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NRN1 neuritin 1
NRP1 neuropilin 1
NT5E 5'-nucleotidase, ecto (CD73)
NXT1 nuclear transport factor 2-like export factor 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PCNA proliferating cell nuclear antigen
PDE4B phosphodiesterase 4B, cAMP-specific
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRMT1 protein arginine methyltransferase 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTX3 pentraxin 3, long
PUS7 pseudouridylate synthase 7 (putative)
RANBP1 RAN binding protein 1
RFTN1 raftlin, lipid raft linker 1
RHOH ras homolog family member H
RPS4Y1 ribosomal protein S4, Y-linked 1
RRM2 ribonucleotide reductase M2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RUVBL1 RuvB-like AAA ATPase 1
S100P S100 calcium binding protein P
SDC1 syndecan 1
SDF2L1 stromal cell-derived factor 2-like 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SH2B3 SH2B adaptor protein 3
SIGMAR1 sigma non-opioid intracellular receptor 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SLC35F2 solute carrier family 35, member F2
SLC43A3 solute carrier family 43, member 3
SMAGP small cell adhesion glycoprotein
SNAI2 snail family zinc finger 2
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SOX9 SRY (sex determining region Y)-box 9
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SRGN serglycin
SRM spermidine synthase
SRPX sushi-repeat containing protein, X-linked
SRSF7 serine/arginine-rich splicing factor 7
STEAP1 six transmembrane epithelial antigen of the prostate 1
STX1A syntaxin 1A (brain)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TARBP1 TAR (HIV-1) RNA binding protein 1
TCL1A T-cell leukemia/lymphoma 1A
TFDP1 transcription factor Dp-1
TFF1 trefoil factor 1
TFPI2 tissue factor pathway inhibitor 2
TGFA transforming growth factor, alpha
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TIPIN TIMELESS interacting protein
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM5 transmembrane protein 5
TSC22D2 TSC22 domain family, member 2
TUBB2A tubulin, beta 2A class IIa
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UCHL5 ubiquitin carboxyl-terminal hydrolase L5
UPP1 uridine phosphorylase 1
VCAN versican
VRK1 vaccinia related kinase 1
ZWINT ZW10 interacting kinetochore protein