BRD-A19500257_geldanamycin_HME1_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

267 genes differentially expressed following the BRD-A19500257_geldanamycin_HME1_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACKR3 atypical chemokine receptor 3
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTG2 actin, gamma 2, smooth muscle, enteric
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ALCAM activated leukocyte cell adhesion molecule
ARID5B AT rich interactive domain 5B (MRF1-like)
ASCL1 achaete-scute family bHLH transcription factor 1
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BRD8 bromodomain containing 8
C1S complement component 1, s subcomponent
C6ORF48 chromosome 6 open reading frame 48
CADM1 cell adhesion molecule 1
CALCOCO1 calcium binding and coiled-coil domain 1
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCDC28A coiled-coil domain containing 28A
CCNG1 cyclin G1
CD58 CD58 molecule
CLIP3 CAP-GLY domain containing linker protein 3
CLU clusterin
CNN1 calponin 1, basic, smooth muscle
COL2A1 collagen, type II, alpha 1
COL3A1 collagen, type III, alpha 1
CRYAB crystallin, alpha B
DAPK1 death-associated protein kinase 1
DDR1 discoidin domain receptor tyrosine kinase 1
DENND4C DENN/MADD domain containing 4C
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DVL3 dishevelled segment polarity protein 3
EFHD1 EF-hand domain family, member D1
EIF3F eukaryotic translation initiation factor 3, subunit F
EIF4B eukaryotic translation initiation factor 4B
FAM134A family with sequence similarity 134, member A
FAXDC2 fatty acid hydroxylase domain containing 2
FBLN1 fibulin 1
FNBP1 formin binding protein 1
FOXO4 forkhead box O4
FTH1 ferritin, heavy polypeptide 1
FXR1 fragile X mental retardation, autosomal homolog 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GCC2 GRIP and coiled-coil domain containing 2
GLUL glutamate-ammonia ligase
GOLGB1 golgin B1
GOLPH3L golgi phosphoprotein 3-like
GPNMB glycoprotein (transmembrane) nmb
GPRC5B G protein-coupled receptor, class C, group 5, member B
GRN granulin
HECA headcase homolog (Drosophila)
HIST1H1C histone cluster 1, H1c
HIST2H2BE histone cluster 2, H2be
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HOXA5 homeobox A5
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPA2 heat shock 70kDa protein 2
HSPA4L heat shock 70kDa protein 4-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
HSPB8 heat shock 22kDa protein 8
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IGBP1 immunoglobulin (CD79A) binding protein 1
IGF1R insulin-like growth factor 1 receptor
IGFBP3 insulin-like growth factor binding protein 3
ITGA8 integrin, alpha 8
ITM2C integral membrane protein 2C
KDM5B lysine (K)-specific demethylase 5B
KIZ kizuna centrosomal protein
KLHL24 kelch-like family member 24
LBH limb bud and heart development
LITAF lipopolysaccharide-induced TNF factor
LMOD1 leiomodin 1 (smooth muscle)
LTBP1 latent transforming growth factor beta binding protein 1
MAN2B1 mannosidase, alpha, class 2B, member 1
MATN2 matrilin 2
MEIS1 Meis homeobox 1
MEIS2 Meis homeobox 2
MINK1 misshapen-like kinase 1
MN1 meningioma (disrupted in balanced translocation) 1
MXI1 MAX interactor 1, dimerization protein
MYL9 myosin, light chain 9, regulatory
MYLK myosin light chain kinase
N4BP2L1 NEDD4 binding protein 2-like 1
NUPR1 nuclear protein, transcriptional regulator, 1
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin
OSBPL9 oxysterol binding protein-like 9
OXTR oxytocin receptor
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PBX1 pre-B-cell leukemia homeobox 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDE10A phosphodiesterase 10A
PDLIM1 PDZ and LIM domain 1
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
PLCB4 phospholipase C, beta 4
PLXNB2 plexin B2
PNRC1 proline-rich nuclear receptor coactivator 1
PROM1 prominin 1
PRSS12 protease, serine, 12 (neurotrypsin, motopsin)
PRUNE2 prune homolog 2 (Drosophila)
PSAP prosaposin
PTN pleiotrophin
PTPN6 protein tyrosine phosphatase, non-receptor type 6
QARS glutaminyl-tRNA synthetase
QPRT quinolinate phosphoribosyltransferase
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RELN reelin
RIOK3 RIO kinase 3
RNASET2 ribonuclease T2
RPL14 ribosomal protein L14
RPL28 ribosomal protein L28
RPL31 ribosomal protein L31
SEPP1 selenoprotein P, plasma, 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SNCAIP synuclein, alpha interacting protein
SOD2 superoxide dismutase 2, mitochondrial
SPON2 spondin 2, extracellular matrix protein
ST5 suppression of tumorigenicity 5
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STK38 serine/threonine kinase 38
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TAGLN transgelin
TLE4 transducin-like enhancer of split 4
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOX thymocyte selection-associated high mobility group box
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
TPP1 tripeptidyl peptidase I
TTC28 tetratricopeptide repeat domain 28
TUFT1 tuftelin 1
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VAT1 vesicle amine transport 1
VNN1 vanin 1
WBP2 WW domain binding protein 2
WDTC1 WD and tetratricopeptide repeats 1
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)
ZHX2 zinc fingers and homeoboxes 2
ZMAT3 zinc finger, matrin-type 3
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF91 zinc finger protein 91
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AREG amphiregulin
ARHGAP29 Rho GTPase activating protein 29
ARPC5L actin related protein 2/3 complex, subunit 5-like
ASPH aspartate beta-hydroxylase
CBFB core-binding factor, beta subunit
CCDC86 coiled-coil domain containing 86
CCL19 chemokine (C-C motif) ligand 19
CCND1 cyclin D1
CD36 CD36 molecule (thrombospondin receptor)
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
COMP cartilage oligomeric matrix protein
CXCL8 chemokine (C-X-C motif) ligand 8
CXCL9 chemokine (C-X-C motif) ligand 9
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EBP emopamil binding protein (sterol isomerase)
EEF1E1 eukaryotic translation elongation factor 1 epsilon 1
EGR2 early growth response 2
EGR3 early growth response 3
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF5A eukaryotic translation initiation factor 5A
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMG1 EMG1 N1-specific pseudouridine methyltransferase
EMP1 epithelial membrane protein 1
ENO1 enolase 1, (alpha)
EREG epiregulin
ETV1 ets variant 1
EXOSC2 exosome component 2
F3 coagulation factor III (thromboplastin, tissue factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FEN1 flap structure-specific endonuclease 1
FKBP11 FK506 binding protein 11, 19 kDa
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GAL galanin/GMAP prepropeptide
GGCT gamma-glutamylcyclotransferase
GINS2 GINS complex subunit 2 (Psf2 homolog)
HBEGF heparin-binding EGF-like growth factor
HMGA2 high mobility group AT-hook 2
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HOPX HOP homeobox
ICMT isoprenylcysteine carboxyl methyltransferase
IER3 immediate early response 3
INHBA inhibin, beta A
ITGB5 integrin, beta 5
JUN jun proto-oncogene
LPL lipoprotein lipase
LTF lactotransferrin
MALL mal, T-cell differentiation protein-like
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MET MET proto-oncogene, receptor tyrosine kinase
MMD monocyte to macrophage differentiation-associated
MMP1 matrix metallopeptidase 1
MMP9 matrix metallopeptidase 9
MPZL2 myelin protein zero-like 2
MRPL15 mitochondrial ribosomal protein L15
MYC v-myc avian myelocytomatosis viral oncogene homolog
NELL2 NEL-like 2 (chicken)
NME1 NME/NM23 nucleoside diphosphate kinase 1
NRP1 neuropilin 1
NT5E 5'-nucleotidase, ecto (CD73)
NXT1 nuclear transport factor 2-like export factor 1
PCSK1 proprotein convertase subtilisin/kexin type 1
PDE4B phosphodiesterase 4B, cAMP-specific
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PLK1 polo-like kinase 1
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PPARG peroxisome proliferator-activated receptor gamma
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTX3 pentraxin 3, long
PUS7 pseudouridylate synthase 7 (putative)
RANBP1 RAN binding protein 1
RPS4Y1 ribosomal protein S4, Y-linked 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RUVBL1 RuvB-like AAA ATPase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCML1 sex comb on midleg-like 1 (Drosophila)
SDF2L1 stromal cell-derived factor 2-like 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SNAI2 snail family zinc finger 2
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SRM spermidine synthase
SRPX sushi-repeat containing protein, X-linked
STC1 stanniocalcin 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
STX1A syntaxin 1A (brain)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFF1 trefoil factor 1
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TIPIN TIMELESS interacting protein
TM4SF1 transmembrane 4 L six family member 1
TMEM5 transmembrane protein 5
TNC tenascin C
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRAPPC4 trafficking protein particle complex 4
TUBA4A tubulin, alpha 4a
TUBB6 tubulin, beta 6 class V
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UPP1 uridine phosphorylase 1
ZWINT ZW10 interacting kinetochore protein