BRD-A19500257_geldanamycin_HEPG2_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

398 genes differentially expressed following the BRD-A19500257_geldanamycin_HEPG2_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABI1 abl-interactor 1
ACPP acid phosphatase, prostate
ACSL1 acyl-CoA synthetase long-chain family member 1
ACSL3 acyl-CoA synthetase long-chain family member 3
ADCK3 aarF domain containing kinase 3
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ALCAM activated leukocyte cell adhesion molecule
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANXA11 annexin A11
AP1G1 adaptor-related protein complex 1, gamma 1 subunit
ARHGAP6 Rho GTPase activating protein 6
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ASMTL acetylserotonin O-methyltransferase-like
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1
BAG3 BCL2-associated athanogene 3
BBX bobby sox homolog (Drosophila)
BCAM basal cell adhesion molecule (Lutheran blood group)
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTN3A2 butyrophilin, subfamily 3, member A2
C1ORF115 chromosome 1 open reading frame 115
CA4 carbonic anhydrase IV
CAST calpastatin
CCDC6 coiled-coil domain containing 6
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCL5 chemokine (C-C motif) ligand 5
CD177 CD177 molecule
CD59 CD59 molecule, complement regulatory protein
CFLAR CASP8 and FADD-like apoptosis regulator
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CGA glycoprotein hormones, alpha polypeptide
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLCA4 chloride channel accessory 4
CLDN5 claudin 5
CLDN8 claudin 8
CLIC5 chloride intracellular channel 5
CLSTN1 calsyntenin 1
COX4I1 cytochrome c oxidase subunit IV isoform 1
CPB1 carboxypeptidase B1 (tissue)
CPVL carboxypeptidase, vitellogenic-like
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYTH1 cytohesin 1
DDHD2 DDHD domain containing 2
DIDO1 death inducer-obliterator 1
DUSP14 dual specificity phosphatase 14
ECM1 extracellular matrix protein 1
ERP44 endoplasmic reticulum protein 44
FBXO11 F-box protein 11
FGFR1 fibroblast growth factor receptor 1
FNBP1 formin binding protein 1
FOXJ3 forkhead box J3
FSTL1 follistatin-like 1
FXR1 fragile X mental retardation, autosomal homolog 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GLG1 golgi glycoprotein 1
GLUL glutamate-ammonia ligase
GMPR guanosine monophosphate reductase
GOLM1 golgi membrane protein 1
GPNMB glycoprotein (transmembrane) nmb
GPR137B G protein-coupled receptor 137B
GRB14 growth factor receptor-bound protein 14
GREB1 growth regulation by estrogen in breast cancer 1
GSN gelsolin
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
GZMK granzyme K (granzyme 3; tryptase II)
H1FX H1 histone family, member X
HBB hemoglobin, beta
HECA headcase homolog (Drosophila)
HIST1H2BG histone cluster 1, H2bg
HIST2H2BE histone cluster 2, H2be
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-E major histocompatibility complex, class I, E
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HSBP1 heat shock factor binding protein 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPA1A heat shock 70kDa protein 1A
HSPB1 heat shock 27kDa protein 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IDS iduronate 2-sulfatase
IFRD1 interferon-related developmental regulator 1
IGLL1 immunoglobulin lambda-like polypeptide 1
IL1RN interleukin 1 receptor antagonist
IL7R interleukin 7 receptor
INSM1 insulinoma-associated 1
IST1 increased sodium tolerance 1 homolog (yeast)
JAM3 junctional adhesion molecule 3
KIAA0368 KIAA0368
KLHL24 kelch-like family member 24
KLRB1 killer cell lectin-like receptor subfamily B, member 1
KRT4 keratin 4, type II
LAPTM5 lysosomal protein transmembrane 5
LBH limb bud and heart development
LCN2 lipocalin 2
LTF lactotransferrin
LY6D lymphocyte antigen 6 complex, locus D
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MARCH8 membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MKRN1 makorin ring finger protein 1
MLF1 myeloid leukemia factor 1
MMP7 matrix metallopeptidase 7
MPPED2 metallophosphoesterase domain containing 2
MPZL1 myelin protein zero-like 1
MS4A12 membrane-spanning 4-domains, subfamily A, member 12
MSMB microseminoprotein, beta-
MYO10 myosin X
MYO1D myosin ID
MYO5A myosin VA (heavy chain 12, myoxin)
NAP1L1 nucleosome assembly protein 1-like 1
NBL1 neuroblastoma 1, DAN family BMP antagonist
NCK2 NCK adaptor protein 2
NCOA3 nuclear receptor coactivator 3
NDRG1 N-myc downstream regulated 1
NEFH neurofilament, heavy polypeptide
NR4A3 nuclear receptor subfamily 4, group A, member 3
OSBPL2 oxysterol binding protein-like 2
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PAPOLA poly(A) polymerase alpha
PCDH9 protocadherin 9
PCP4 Purkinje cell protein 4
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFC platelet derived growth factor C
PDIA3 protein disulfide isomerase family A, member 3
PI3 peptidase inhibitor 3, skin-derived
PIAS1 protein inhibitor of activated STAT, 1
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2
PNMAL1 paraneoplastic Ma antigen family-like 1
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PRNP prion protein
PROM1 prominin 1
PSAP prosaposin
PTTG1IP pituitary tumor-transforming 1 interacting protein
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RABGAP1L RAB GTPase activating protein 1-like
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RB1CC1 RB1-inducible coiled-coil 1
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RGCC regulator of cell cycle
RGS10 regulator of G-protein signaling 10
RHOH ras homolog family member H
RNF11 ring finger protein 11
RNF114 ring finger protein 114
RUNX3 runt-related transcription factor 3
RYBP RING1 and YY1 binding protein
S100A7 S100 calcium binding protein A7
SARAF store-operated calcium entry-associated regulatory factor
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SDC2 syndecan 2
SDCBP syndecan binding protein (syntenin)
SERINC5 serine incorporator 5
SF3B1 splicing factor 3b, subunit 1, 155kDa
SGK1 serum/glucocorticoid regulated kinase 1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SRSF5 serine/arginine-rich splicing factor 5
STK17B serine/threonine kinase 17b
STK24 serine/threonine kinase 24
STOM stomatin
STS steroid sulfatase (microsomal), isozyme S
STYK1 serine/threonine/tyrosine kinase 1
TARP TCR gamma alternate reading frame protein
TBC1D4 TBC1 domain family, member 4
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THUMPD1 THUMP domain containing 1
TM9SF2 transmembrane 9 superfamily member 2
TMCO1 transmembrane and coiled-coil domains 1
TMEM255A transmembrane protein 255A
TMX4 thioredoxin-related transmembrane protein 4
TNPO1 transportin 1
TUSC3 tumor suppressor candidate 3
TXNIP thioredoxin interacting protein
UBXN7 UBX domain protein 7
UGCG UDP-glucose ceramide glucosyltransferase
UGDH UDP-glucose 6-dehydrogenase
USP12 ubiquitin specific peptidase 12
USP33 ubiquitin specific peptidase 33
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1
WDR48 WD repeat domain 48
XIST X inactive specific transcript (non-protein coding)
YBX3 Y box binding protein 3
YPEL5 yippee-like 5 (Drosophila)
ZDHHC7 zinc finger, DHHC-type containing 7

decreased expression

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABLIM1 actin binding LIM protein 1
ACTG2 actin, gamma 2, smooth muscle, enteric
ADIRF adipogenesis regulatory factor
AFP alpha-fetoprotein
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AHNAK2 AHNAK nucleoprotein 2
AHR aryl hydrocarbon receptor
AKAP12 A kinase (PRKA) anchor protein 12
AMDHD2 amidohydrolase domain containing 2
AMIGO2 adhesion molecule with Ig-like domain 2
ANKRD36B ankyrin repeat domain 36B
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ASCC3 activating signal cointegrator 1 complex subunit 3
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BHLHE41 basic helix-loop-helix family, member e41
BRCA1 breast cancer 1, early onset
BTG2 BTG family, member 2
C1RL complement component 1, r subcomponent-like
C3 complement component 3
C9ORF3 chromosome 9 open reading frame 3
CADM1 cell adhesion molecule 1
CAPRIN2 caprin family member 2
CCND1 cyclin D1
CD24 CD24 molecule
CD44 CD44 molecule (Indian blood group)
CDC45 cell division cycle 45
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CETN3 centrin, EF-hand protein, 3
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CLDN7 claudin 7
COA3 cytochrome c oxidase assembly factor 3
COA4 cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae)
COL11A1 collagen, type XI, alpha 1
COPS7A COP9 signalosome subunit 7A
CP ceruloplasmin (ferroxidase)
CXCL14 chemokine (C-X-C motif) ligand 14
CYR61 cysteine-rich, angiogenic inducer, 61
DCN decorin
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DESI1 desumoylating isopeptidase 1
DFNA5 deafness, autosomal dominant 5
DHFR dihydrofolate reductase
DHRS2 dehydrogenase/reductase (SDR family) member 2
DIO1 deiodinase, iodothyronine, type I
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
DPH2 DPH2 homolog (S. cerevisiae)
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EEF1E1 eukaryotic translation elongation factor 1 epsilon 1
EFS embryonal Fyn-associated substrate
EIF5 eukaryotic translation initiation factor 5
EIF5A eukaryotic translation initiation factor 5A
EMG1 EMG1 N1-specific pseudouridine methyltransferase
ENPEP glutamyl aminopeptidase (aminopeptidase A)
ERBB3 erb-b2 receptor tyrosine kinase 3
ERGIC2 ERGIC and golgi 2
ESR1 estrogen receptor 1
EXT1 exostosin glycosyltransferase 1
F3 coagulation factor III (thromboplastin, tissue factor)
FAM216A family with sequence similarity 216, member A
FAM57A family with sequence similarity 57, member A
FAM86B1 family with sequence similarity 86, member B1
FARSA phenylalanyl-tRNA synthetase, alpha subunit
FOLR1 folate receptor 1 (adult)
G0S2 G0/G1 switch 2
GALE UDP-galactose-4-epimerase
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
GATA3 GATA binding protein 3
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GPX1 glutathione peroxidase 1
GTF2H1 general transcription factor IIH, polypeptide 1, 62kDa
HES1 hes family bHLH transcription factor 1
HMGA2 high mobility group AT-hook 2
HNMT histamine N-methyltransferase
ICAM1 intercellular adhesion molecule 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFRD2 interferon-related developmental regulator 2
IGKV4-1 immunoglobulin kappa variable 4-1
INHBA inhibin, beta A
IPO4 importin 4
ISG15 ISG15 ubiquitin-like modifier
ITGB4 integrin, beta 4
JCHAIN joining chain of multimeric IgA and IgM
KCTD12 potassium channel tetramerization domain containing 12
KIAA0391 KIAA0391
KIAA1033 KIAA1033
KRCC1 lysine-rich coiled-coil 1
KRT19 keratin 19, type I
KRT7 keratin 7, type II
KRT8 keratin 8, type II
LAMA3 laminin, alpha 3
LIF leukemia inhibitory factor
LOC100505650 uncharacterized LOC100505650
LOX lysyl oxidase
LUM lumican
MAB21L2 mab-21-like 2 (C. elegans)
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP1B microtubule-associated protein 1B
MCM3 minichromosome maintenance complex component 3
MEA1 male-enhanced antigen 1
MGP matrix Gla protein
MPV17 MpV17 mitochondrial inner membrane protein
MPZL2 myelin protein zero-like 2
MRPL12 mitochondrial ribosomal protein L12
MRPL17 mitochondrial ribosomal protein L17
MRPL24 mitochondrial ribosomal protein L24
MRPL57 mitochondrial ribosomal protein L57
MRPS12 mitochondrial ribosomal protein S12
MSLN mesothelin
MSRB1 methionine sulfoxide reductase B1
MTCH2 mitochondrial carrier 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
MZB1 marginal zone B and B1 cell-specific protein
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NBN nibrin
NDUFAF3 NADH dehydrogenase (ubiquinone) complex I, assembly factor 3
NEFL neurofilament, light polypeptide
NME1 NME/NM23 nucleoside diphosphate kinase 1
NNMT nicotinamide N-methyltransferase
NQO1 NAD(P)H dehydrogenase, quinone 1
NQO2 NAD(P)H dehydrogenase, quinone 2
NT5E 5'-nucleotidase, ecto (CD73)
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2
OXLD1 oxidoreductase-like domain containing 1
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDLIM4 PDZ and LIM domain 4
PEG3 paternally expressed 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIGF phosphatidylinositol glycan anchor biosynthesis, class F
PKP2 plakophilin 2
PLAU plasminogen activator, urokinase
PLN phospholamban
PLS1 plastin 1
PLS3 plastin 3
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
PNMA2 paraneoplastic Ma antigen 2
PNP purine nucleoside phosphorylase
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
POSTN periostin, osteoblast specific factor
PREB prolactin regulatory element binding
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PURA purine-rich element binding protein A
PUS7 pseudouridylate synthase 7 (putative)
QTRT1 queuine tRNA-ribosyltransferase 1
RAB29 RAB29, member RAS oncogene family
RAD51C RAD51 paralog C
RBBP8 retinoblastoma binding protein 8
RBKS ribokinase
RBPMS RNA binding protein with multiple splicing
RFTN1 raftlin, lipid raft linker 1
RHOB ras homolog family member B
RNASEH2A ribonuclease H2, subunit A
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RUVBL1 RuvB-like AAA ATPase 1
S100A2 S100 calcium binding protein A2
S100A6 S100 calcium binding protein A6
SCGB2A1 secretoglobin, family 2A, member 1
SCRG1 stimulator of chondrogenesis 1
SDC1 syndecan 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLC38A1 solute carrier family 38, member 1
SLC38A2 solute carrier family 38, member 2
SMAD1 SMAD family member 1
SOX4 SRY (sex determining region Y)-box 4
SRM spermidine synthase
SRSF7 serine/arginine-rich splicing factor 7
SULF1 sulfatase 1
TACSTD2 tumor-associated calcium signal transducer 2
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
TAGLN transgelin
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
THBS1 thrombospondin 1
THTPA thiamine triphosphatase
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TM4SF1 transmembrane 4 L six family member 1
TMEM223 transmembrane protein 223
TMEM5 transmembrane protein 5
TNC tenascin C
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TP53I3 tumor protein p53 inducible protein 3
TRIP13 thyroid hormone receptor interactor 13
TYMS thymidylate synthetase
UBE2A ubiquitin-conjugating enzyme E2A
UBE3C ubiquitin protein ligase E3C
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
VCAN versican
XBP1 X-box binding protein 1
ZDHHC6 zinc finger, DHHC-type containing 6
ZNF593 zinc finger protein 593
ZWINT ZW10 interacting kinetochore protein