BRD-A19500257_geldanamycin_HEPG2_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

329 genes differentially expressed following the BRD-A19500257_geldanamycin_HEPG2_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABI1 abl-interactor 1
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACPP acid phosphatase, prostate
ADCK3 aarF domain containing kinase 3
ADGRE5 adhesion G protein-coupled receptor E5
ADI1 acireductone dioxygenase 1
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
ANXA11 annexin A11
AQP9 aquaporin 9
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BAG3 BCL2-associated athanogene 3
BBX bobby sox homolog (Drosophila)
BCL2A1 BCL2-related protein A1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTK Bruton agammaglobulinemia tyrosine kinase
C1ORF115 chromosome 1 open reading frame 115
C1ORF54 chromosome 1 open reading frame 54
CA1 carbonic anhydrase I
CCL2 chemokine (C-C motif) ligand 2
CCL5 chemokine (C-C motif) ligand 5
CD59 CD59 molecule, complement regulatory protein
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHN1 chimerin 1
CLDN8 claudin 8
CLSTN1 calsyntenin 1
COL4A5 collagen, type IV, alpha 5
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CSRP2 cysteine and glycine-rich protein 2
CYTH1 cytohesin 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DUSP14 dual specificity phosphatase 14
DUSP22 dual specificity phosphatase 22
ECM1 extracellular matrix protein 1
ELF4 E74-like factor 4 (ets domain transcription factor)
ERP44 endoplasmic reticulum protein 44
EZR ezrin
FABP4 fatty acid binding protein 4, adipocyte
FAM129A family with sequence similarity 129, member A
FBXO11 F-box protein 11
FNBP1 formin binding protein 1
FOLR1 folate receptor 1 (adult)
FOXJ3 forkhead box J3
FSTL1 follistatin-like 1
FXR1 fragile X mental retardation, autosomal homolog 1
FZD7 frizzled class receptor 7
GLG1 golgi glycoprotein 1
GLUL glutamate-ammonia ligase
GYPC glycophorin C (Gerbich blood group)
HBB hemoglobin, beta
HBD hemoglobin, delta
HECA headcase homolog (Drosophila)
HIST2H2BE histone cluster 2, H2be
HIST3H2A histone cluster 3, H2a
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOXB2 homeobox B2
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPB1 heat shock 27kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
IDS iduronate 2-sulfatase
IFI27 interferon, alpha-inducible protein 27
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL1R2 interleukin 1 receptor, type II
IL7R interleukin 7 receptor
KLHL24 kelch-like family member 24
KRT4 keratin 4, type II
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
LAPTM5 lysosomal protein transmembrane 5
LCN2 lipocalin 2
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LEF1 lymphoid enhancer-binding factor 1
LIMS1 LIM and senescent cell antigen-like domains 1
LITAF lipopolysaccharide-induced TNF factor
LTF lactotransferrin
LY6D lymphocyte antigen 6 complex, locus D
LYZ lysozyme
MKNK2 MAP kinase interacting serine/threonine kinase 2
MKRN1 makorin ring finger protein 1
MME membrane metallo-endopeptidase
MMP12 matrix metallopeptidase 12
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MNAT1 MNAT CDK-activating kinase assembly factor 1
MSMB microseminoprotein, beta-
MXD4 MAX dimerization protein 4
MYO10 myosin X
MYO5A myosin VA (heavy chain 12, myoxin)
NCOA3 nuclear receptor coactivator 3
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NPIPB3 nuclear pore complex interacting protein family, member B3
NRIP3 nuclear receptor interacting protein 3
OSBPL2 oxysterol binding protein-like 2
OXTR oxytocin receptor
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDLIM1 PDZ and LIM domain 1
PI3 peptidase inhibitor 3, skin-derived
PLTP phospholipid transfer protein
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRAME preferentially expressed antigen in melanoma
PRDX6 peroxiredoxin 6
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RHOH ras homolog family member H
RUNX3 runt-related transcription factor 3
RYBP RING1 and YY1 binding protein
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SARAF store-operated calcium entry-associated regulatory factor
SCUBE2 signal peptide, CUB domain, EGF-like 2
SDCBP syndecan binding protein (syntenin)
SELENBP1 selenium binding protein 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
SEPP1 selenoprotein P, plasma, 1
SERINC5 serine incorporator 5
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group)
SPEN spen family transcriptional repressor
SQRDL sulfide quinone reductase-like (yeast)
STAB1 stabilin 1
TACC1 transforming, acidic coiled-coil containing protein 1
TBC1D4 TBC1 domain family, member 4
TMPRSS2 transmembrane protease, serine 2
TRAF5 TNF receptor-associated factor 5
TRIM38 tripartite motif containing 38
TXNIP thioredoxin interacting protein
UBXN7 UBX domain protein 7
UGCG UDP-glucose ceramide glucosyltransferase
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VAV3 vav 3 guanine nucleotide exchange factor
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)
ZDHHC7 zinc finger, DHHC-type containing 7
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
ACD adrenocortical dysplasia homolog (mouse)
ADGRG2 adhesion G protein-coupled receptor G2
ADIRF adipogenesis regulatory factor
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AHR aryl hydrocarbon receptor
AK1 adenylate kinase 1
AK2 adenylate kinase 2
AMDHD2 amidohydrolase domain containing 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANKRD10 ankyrin repeat domain 10
ANXA1 annexin A1
ANXA3 annexin A3
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ASCC3 activating signal cointegrator 1 complex subunit 3
ASL argininosuccinate lyase
ASPH aspartate beta-hydroxylase
ASPN asporin
ATP5G1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
AURKB aurora kinase B
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BEX1 brain expressed, X-linked 1
BGN biglycan
BHLHE41 basic helix-loop-helix family, member e41
C11ORF71 chromosome 11 open reading frame 71
CADM1 cell adhesion molecule 1
CCND2 cyclin D2
CD24 CD24 molecule
CD3EAP CD3e molecule, epsilon associated protein
CD44 CD44 molecule (Indian blood group)
CHRDL1 chordin-like 1
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
COA4 cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae)
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
COMP cartilage oligomeric matrix protein
CSTA cystatin A (stefin A)
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL12 chemokine (C-X-C motif) ligand 12
CYCS cytochrome c, somatic
CYR61 cysteine-rich, angiogenic inducer, 61
DACH1 dachshund family transcription factor 1
DCN decorin
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DESI1 desumoylating isopeptidase 1
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
DPH2 DPH2 homolog (S. cerevisiae)
DPYSL3 dihydropyrimidinase-like 3
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
DYNLT1 dynein, light chain, Tctex-type 1
EDNRA endothelin receptor type A
EIF5 eukaryotic translation initiation factor 5
EMG1 EMG1 N1-specific pseudouridine methyltransferase
ENO1 enolase 1, (alpha)
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ERGIC2 ERGIC and golgi 2
F3 coagulation factor III (thromboplastin, tissue factor)
FAM216A family with sequence similarity 216, member A
FAM57A family with sequence similarity 57, member A
FOXM1 forkhead box M1
FRZB frizzled-related protein
FXYD3 FXYD domain containing ion transport regulator 3
GALE UDP-galactose-4-epimerase
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GIMAP6 GTPase, IMAP family member 6
GPX1 glutathione peroxidase 1
GRB7 growth factor receptor-bound protein 7
HN1 hematological and neurological expressed 1
HNMT histamine N-methyltransferase
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HOPX HOP homeobox
ICAM1 intercellular adhesion molecule 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFI44L interferon-induced protein 44-like
IFRD2 interferon-related developmental regulator 2
IGFBP7 insulin-like growth factor binding protein 7
IGHM immunoglobulin heavy constant mu
IGLJ3 immunoglobulin lambda joining 3
INHBA inhibin, beta A
IPO4 importin 4
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KRT18 keratin 18, type I
KRT19 keratin 19, type I
KRT7 keratin 7, type II
KRT8 keratin 8, type II
LAMB1 laminin, beta 1
LDOC1 leucine zipper, down-regulated in cancer 1
LOC100505650 uncharacterized LOC100505650
LUM lumican
MAB21L2 mab-21-like 2 (C. elegans)
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP7 microtubule-associated protein 7
MAPK13 mitogen-activated protein kinase 13
MEA1 male-enhanced antigen 1
MEF2C myocyte enhancer factor 2C
MET MET proto-oncogene, receptor tyrosine kinase
MFAP5 microfibrillar associated protein 5
MGP matrix Gla protein
MPZL2 myelin protein zero-like 2
MRPL12 mitochondrial ribosomal protein L12
MRPL57 mitochondrial ribosomal protein L57
MRPS12 mitochondrial ribosomal protein S12
MRPS33 mitochondrial ribosomal protein S33
MSLN mesothelin
MSRB1 methionine sulfoxide reductase B1
NDUFAF3 NADH dehydrogenase (ubiquinone) complex I, assembly factor 3
NFIB nuclear factor I/B
NHP2 NHP2 ribonucleoprotein
NME1 NME/NM23 nucleoside diphosphate kinase 1
NREP neuronal regeneration related protein
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2
OXLD1 oxidoreductase-like domain containing 1
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase
PEG3 paternally expressed 3
PEX10 peroxisomal biogenesis factor 10
PIGF phosphatidylinositol glycan anchor biosynthesis, class F
PLN phospholamban
PLS3 plastin 3
PNP purine nucleoside phosphorylase
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
POSTN periostin, osteoblast specific factor
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PREB prolactin regulatory element binding
PTMA prothymosin, alpha
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RBKS ribokinase
RBPMS RNA binding protein with multiple splicing
RNASEH2A ribonuclease H2, subunit A
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
S100A6 S100 calcium binding protein A6
S100P S100 calcium binding protein P
SCAND1 SCAN domain containing 1
SDC1 syndecan 1
SEPHS1 selenophosphate synthetase 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP4 secreted frizzled-related protein 4
SIGMAR1 sigma non-opioid intracellular receptor 1
SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLC38A1 solute carrier family 38, member 1
SOX4 SRY (sex determining region Y)-box 4
SPTSSA serine palmitoyltransferase, small subunit A
SRM spermidine synthase
STRA13 stimulated by retinoic acid 13
SULF1 sulfatase 1
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
TAGLN transgelin
TFPI2 tissue factor pathway inhibitor 2
THBS2 thrombospondin 2
THTPA thiamine triphosphatase
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TM4SF1 transmembrane 4 L six family member 1
TMEM5 transmembrane protein 5
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNIK TRAF2 and NCK interacting kinase
TP53I3 tumor protein p53 inducible protein 3
TRAPPC4 trafficking protein particle complex 4
TRIP13 thyroid hormone receptor interactor 13
TSPAN4 tetraspanin 4
TYMP thymidine phosphorylase
TYMS thymidylate synthetase
UBE2A ubiquitin-conjugating enzyme E2A
UBE2S ubiquitin-conjugating enzyme E2S
UBE3C ubiquitin protein ligase E3C
VCAN versican
ZDHHC6 zinc finger, DHHC-type containing 6
ZFPM2 zinc finger protein, FOG family member 2
ZNF593 zinc finger protein 593
ZWINT ZW10 interacting kinetochore protein