BRD-A19500257_geldanamycin_HEPG2_24_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

90 genes differentially expressed following the BRD-A19500257_geldanamycin_HEPG2_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADI1 acireductone dioxygenase 1
AIM2 absent in melanoma 2
ALCAM activated leukocyte cell adhesion molecule
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAG3 BCL2-associated athanogene 3
BCL2A1 BCL2-related protein A1
CCNG2 cyclin G2
CD163 CD163 molecule
CD59 CD59 molecule, complement regulatory protein
CDK19 cyclin-dependent kinase 19
CFH complement factor H
CTSB cathepsin B
CYTIP cytohesin 1 interacting protein
GLUL glutamate-ammonia ligase
HBB hemoglobin, beta
HECA headcase homolog (Drosophila)
HIST1H2BG histone cluster 1, H2bg
HOXB2 homeobox B2
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HSPA1A heat shock 70kDa protein 1A
HSPB1 heat shock 27kDa protein 1
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
IL7R interleukin 7 receptor
KRT14 keratin 14, type I
LTF lactotransferrin
MMP9 matrix metallopeptidase 9
MTUS1 microtubule associated tumor suppressor 1
MYO10 myosin X
MYO5A myosin VA (heavy chain 12, myoxin)
NOTCH2NL notch 2 N-terminal like
OXTR oxytocin receptor
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCDH9 protocadherin 9
PRNP prion protein
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
RUNX3 runt-related transcription factor 3
S100A8 S100 calcium binding protein A8
SDCBP syndecan binding protein (syntenin)
SGK1 serum/glucocorticoid regulated kinase 1
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SOD2 superoxide dismutase 2, mitochondrial
STAB1 stabilin 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ANKRD10 ankyrin repeat domain 10
BEX1 brain expressed, X-linked 1
CCNA2 cyclin A2
CD24 CD24 molecule
CDC45 cell division cycle 45
CEMIP cell migration inducing protein, hyaluronan binding
CLGN calmegin
COL1A2 collagen, type I, alpha 2
CXADR coxsackie virus and adenovirus receptor
CXCL12 chemokine (C-X-C motif) ligand 12
DHRS2 dehydrogenase/reductase (SDR family) member 2
EDNRA endothelin receptor type A
EMG1 EMG1 N1-specific pseudouridine methyltransferase
GNAS GNAS complex locus
GSTM3 glutathione S-transferase mu 3 (brain)
HN1 hematological and neurological expressed 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFI44L interferon-induced protein 44-like
KRT19 keratin 19, type I
KRT8 keratin 8, type II
LAMB1 laminin, beta 1
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
MAB21L2 mab-21-like 2 (C. elegans)
MDK midkine (neurite growth-promoting factor 2)
MRPS16 mitochondrial ribosomal protein S16
MSLN mesothelin
NREP neuronal regeneration related protein
ODC1 ornithine decarboxylase 1
PDE3B phosphodiesterase 3B, cGMP-inhibited
PEG3 paternally expressed 3
PLAT plasminogen activator, tissue
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PTGIS prostaglandin I2 (prostacyclin) synthase
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SET SET nuclear proto-oncogene
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SPON1 spondin 1, extracellular matrix protein
TM4SF1 transmembrane 4 L six family member 1
TRMT5 tRNA methyltransferase 5
TYMS thymidylate synthetase
VCAN versican