BRD-A19500257_geldanamycin_HEC108_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

64 genes differentially expressed following the BRD-A19500257_geldanamycin_HEC108_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BAG3 BCL2-associated athanogene 3
BAX BCL2-associated X protein
BEX4 brain expressed, X-linked 4
CLIC4 chloride intracellular channel 4
CNPY3 canopy FGF signaling regulator 3
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EGFR epidermal growth factor receptor
FAM129A family with sequence similarity 129, member A
FGFR2 fibroblast growth factor receptor 2
FHL1 four and a half LIM domains 1
GOT1 glutamic-oxaloacetic transaminase 1, soluble
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HYOU1 hypoxia up-regulated 1
LYZ lysozyme
MAN2A1 mannosidase, alpha, class 2A, member 1
MANF mesencephalic astrocyte-derived neurotrophic factor
MAP7 microtubule-associated protein 7
MYOF myoferlin
NEBL nebulette
NFE2L2 nuclear factor, erythroid 2-like 2
NUCB2 nucleobindin 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCP4 Purkinje cell protein 4
PDIA3 protein disulfide isomerase family A, member 3
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PPIB peptidylprolyl isomerase B (cyclophilin B)
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RGS10 regulator of G-protein signaling 10
S100A8 S100 calcium binding protein A8
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
TMEM30B transmembrane protein 30B
WARS tryptophanyl-tRNA synthetase

decreased expression

Symbol Name
BST2 bone marrow stromal cell antigen 2
CHMP4A charged multivesicular body protein 4A
CPB1 carboxypeptidase B1 (tissue)
CXCL5 chemokine (C-X-C motif) ligand 5
G0S2 G0/G1 switch 2
HOXC4 homeobox C4
HOXC6 homeobox C6
KIAA0485 uncharacterized LOC57235
LGALS1 lectin, galactoside-binding, soluble, 1
LHFP lipoma HMGIC fusion partner
MEG3 maternally expressed 3 (non-protein coding)
MMD monocyte to macrophage differentiation-associated
NFIB nuclear factor I/B
NRN1 neuritin 1
PEG10 paternally expressed 10
PRSS3 protease, serine, 3
PTDSS1 phosphatidylserine synthase 1
SFN stratifin
SOX4 SRY (sex determining region Y)-box 4
TUBB2B tubulin, beta 2B class IIb
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)