BRD-A19500257_geldanamycin_HCC515_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

331 genes differentially expressed following the BRD-A19500257_geldanamycin_HCC515_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ABHD4 abhydrolase domain containing 4
AFF1 AF4/FMR2 family, member 1
AGR2 anterior gradient 2
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ARL1 ADP-ribosylation factor-like 1
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ARMCX6 armadillo repeat containing, X-linked 6
ASPN asporin
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
AVPI1 arginine vasopressin-induced 1
BAG3 BCL2-associated athanogene 3
BEX1 brain expressed, X-linked 1
BPIFA1 BPI fold containing family A, member 1
CARKD carbohydrate kinase domain containing
CCDC28A coiled-coil domain containing 28A
CCNG2 cyclin G2
CD163 CD163 molecule
CDK19 cyclin-dependent kinase 19
CHPT1 choline phosphotransferase 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COL11A1 collagen, type XI, alpha 1
COL15A1 collagen, type XV, alpha 1
COL5A2 collagen, type V, alpha 2
CRELD2 cysteine-rich with EGF-like domains 2
CRYAB crystallin, alpha B
CST4 cystatin S
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DLK1 delta-like 1 homolog (Drosophila)
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15
EGFL6 EGF-like-domain, multiple 6
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF4B eukaryotic translation initiation factor 4B
ELF1 E74-like factor 1 (ets domain transcription factor)
ELF5 E74-like factor 5 (ets domain transcription factor)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERMP1 endoplasmic reticulum metallopeptidase 1
FAM13B family with sequence similarity 13, member B
FN1 fibronectin 1
FXR1 fragile X mental retardation, autosomal homolog 1
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
GLUL glutamate-ammonia ligase
GPC3 glypican 3
GPM6B glycoprotein M6B
GPX2 glutathione peroxidase 2
GPX3 glutathione peroxidase 3
GREB1 growth regulation by estrogen in breast cancer 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HS2ST1 heparan sulfate 2-O-sulfotransferase 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
HYOU1 hypoxia up-regulated 1
IFI6 interferon, alpha-inducible protein 6
IGHMBP2 immunoglobulin mu binding protein 2
IGKV1-5 immunoglobulin kappa variable 1-5
IRX5 iroquois homeobox 5
ISG15 ISG15 ubiquitin-like modifier
KLHL24 kelch-like family member 24
KRT13 keratin 13, type I
KRT14 keratin 14, type I
KRT19 keratin 19, type I
LAMP2 lysosomal-associated membrane protein 2
LCN2 lipocalin 2
LRRC16A leucine rich repeat containing 16A
MAGED1 melanoma antigen family D1
MAGED2 melanoma antigen family D2
MAOA monoamine oxidase A
MERTK MER proto-oncogene, tyrosine kinase
MGP matrix Gla protein
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MSMB microseminoprotein, beta-
MYL9 myosin, light chain 9, regulatory
NAV2 neuron navigator 2
NEU1 sialidase 1 (lysosomal sialidase)
NR1H2 nuclear receptor subfamily 1, group H, member 2
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9
NUPR1 nuclear protein, transcriptional regulator, 1
ODC1 ornithine decarboxylase 1
OFD1 oral-facial-digital syndrome 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCDH9 protocadherin 9
PCGF1 polycomb group ring finger 1
PDIA3 protein disulfide isomerase family A, member 3
PER1 period circadian clock 1
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PIP prolactin-induced protein
POSTN periostin, osteoblast specific factor
POU2AF1 POU class 2 associating factor 1
PPIB peptidylprolyl isomerase B (cyclophilin B)
PRKCZ protein kinase C, zeta
PROM1 prominin 1
PRSS23 protease, serine, 23
QPRT quinolinate phosphoribosyltransferase
RALGDS ral guanine nucleotide dissociation stimulator
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RGS2 regulator of G-protein signaling 2
RGS5 regulator of G-protein signaling 5
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
S100P S100 calcium binding protein P
SARAF store-operated calcium entry-associated regulatory factor
SAT1 spermidine/spermine N1-acetyltransferase 1
SC5D sterol-C5-desaturase
SEC31A SEC31 homolog A (S. cerevisiae)
SEPP1 selenoprotein P, plasma, 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SGK1 serum/glucocorticoid regulated kinase 1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SPP1 secreted phosphoprotein 1
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SPRR3 small proline-rich protein 3
SQLE squalene epoxidase
SSBP2 single-stranded DNA binding protein 2
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
STK26 serine/threonine protein kinase 26
SULF1 sulfatase 1
THBS4 thrombospondin 4
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM45A transmembrane protein 45A
TSPAN4 tetraspanin 4
TSPYL5 TSPY-like 5
TXNDC15 thioredoxin domain containing 15
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UGDH UDP-glucose 6-dehydrogenase
VAV3 vav 3 guanine nucleotide exchange factor
VDAC1 voltage-dependent anion channel 1
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ADCY1 adenylate cyclase 1 (brain)
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMIGO2 adhesion molecule with Ig-like domain 2
ARL4C ADP-ribosylation factor-like 4C
ASF1B anti-silencing function 1B histone chaperone
ASRGL1 asparaginase like 1
BHLHE40 basic helix-loop-helix family, member e40
BRCA1 breast cancer 1, early onset
BTG3 BTG family, member 3
C1ORF106 chromosome 1 open reading frame 106
C3 complement component 3
CALML5 calmodulin-like 5
CAPN2 calpain 2, (m/II) large subunit
CARD10 caspase recruitment domain family, member 10
CARHSP1 calcium regulated heat stable protein 1, 24kDa
CCDC109B coiled-coil domain containing 109B
CCL2 chemokine (C-C motif) ligand 2
CCNE2 cyclin E2
CCNF cyclin F
CD44 CD44 molecule (Indian blood group)
CD47 CD47 molecule
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDK2 cyclin-dependent kinase 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDT1 chromatin licensing and DNA replication factor 1
CENPU centromere protein U
CHAF1A chromatin assembly factor 1, subunit A (p150)
CKLF chemokine-like factor
CPOX coproporphyrinogen oxidase
CTPS1 CTP synthase 1
CXCL14 chemokine (C-X-C motif) ligand 14
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEGS1 delta(4)-desaturase, sphingolipid 1
DHFR dihydrofolate reductase
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DPYD dihydropyrimidine dehydrogenase
DPYSL2 dihydropyrimidinase-like 2
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF5A eukaryotic translation initiation factor 5A
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ELOVL6 ELOVL fatty acid elongase 6
EMX2 empty spiracles homeobox 2
EPHA2 EPH receptor A2
EPHB2 EPH receptor B2
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM57A family with sequence similarity 57, member A
FAR2 fatty acyl CoA reductase 2
FEN1 flap structure-specific endonuclease 1
FGFR3 fibroblast growth factor receptor 3
FOSL1 FOS-like antigen 1
FXYD5 FXYD domain containing ion transport regulator 5
GATA2 GATA binding protein 2
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GNG12 guanine nucleotide binding protein (G protein), gamma 12
HAT1 histone acetyltransferase 1
HELLS helicase, lymphoid-specific
HIST1H4C histone cluster 1, H4c
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HOPX HOP homeobox
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IFI16 interferon, gamma-inducible protein 16
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IL13RA2 interleukin 13 receptor, alpha 2
IL17RB interleukin 17 receptor B
IL1R1 interleukin 1 receptor, type I
ITGA6 integrin, alpha 6
JUN jun proto-oncogene
KCTD12 potassium channel tetramerization domain containing 12
KDM5D lysine (K)-specific demethylase 5D
KLF4 Kruppel-like factor 4 (gut)
KRT1 keratin 1, type II
L1CAM L1 cell adhesion molecule
LIF leukemia inhibitory factor
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LRRC17 leucine rich repeat containing 17
MAN1C1 mannosidase, alpha, class 1C, member 1
MAPK9 mitogen-activated protein kinase 9
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MMD monocyte to macrophage differentiation-associated
MPZL2 myelin protein zero-like 2
MSH2 mutS homolog 2
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NASP nuclear autoantigenic sperm protein (histone-binding)
NID1 nidogen 1
NT5DC2 5'-nucleotidase domain containing 2
NT5E 5'-nucleotidase, ecto (CD73)
OSBPL10 oxysterol binding protein-like 10
PAQR4 progestin and adipoQ receptor family member IV
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCNA proliferating cell nuclear antigen
PCSK1 proprotein convertase subtilisin/kexin type 1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PMEPA1 prostate transmembrane protein, androgen induced 1
PNMA2 paraneoplastic Ma antigen 2
POLE polymerase (DNA directed), epsilon, catalytic subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRKCA protein kinase C, alpha
PRKD3 protein kinase D3
PRSS3 protease, serine, 3
PSPH phosphoserine phosphatase
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PUS7 pseudouridylate synthase 7 (putative)
PXMP2 peroxisomal membrane protein 2, 22kDa
RAP1GAP RAP1 GTPase activating protein
RFC2 replication factor C (activator 1) 2, 40kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFTN1 raftlin, lipid raft linker 1
RMI1 RecQ mediated genome instability 1
RNASEH2A ribonuclease H2, subunit A
RPS4Y1 ribosomal protein S4, Y-linked 1
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SATB2 SATB homeobox 2
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFN stratifin
SFRP1 secreted frizzled-related protein 1
SMAD1 SMAD family member 1
SNAI2 snail family zinc finger 2
SOX9 SRY (sex determining region Y)-box 9
SPON1 spondin 1, extracellular matrix protein
STEAP3 STEAP family member 3, metalloreductase
STX1A syntaxin 1A (brain)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TFDP1 transcription factor Dp-1
TGFBI transforming growth factor, beta-induced, 68kDa
TK1 thymidine kinase 1, soluble
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM109 transmembrane protein 109
TMSB15A thymosin beta 15a
TNC tenascin C
TRIB2 tribbles pseudokinase 2
TUBA4A tubulin, alpha 4a
TYMS thymidylate synthetase
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
UNG uracil-DNA glycosylase
USP1 ubiquitin specific peptidase 1
VRK1 vaccinia related kinase 1
WEE1 WEE1 G2 checkpoint kinase
WNT5A wingless-type MMTV integration site family, member 5A
WT1 Wilms tumor 1
ZCCHC24 zinc finger, CCHC domain containing 24