BRD-A19500257_geldanamycin_HCC515_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

351 genes differentially expressed following the BRD-A19500257_geldanamycin_HCC515_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ABHD4 abhydrolase domain containing 4
ADAM10 ADAM metallopeptidase domain 10
ADM adrenomedullin
AFF1 AF4/FMR2 family, member 1
AKAP8L A kinase (PRKA) anchor protein 8-like
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANGPT1 angiopoietin 1
ATF7IP activating transcription factor 7 interacting protein
ATHL1 ATH1, acid trehalase-like 1 (yeast)
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAG3 BCL2-associated athanogene 3
BBX bobby sox homolog (Drosophila)
BEX1 brain expressed, X-linked 1
BEX4 brain expressed, X-linked 4
BPIFA1 BPI fold containing family A, member 1
C1ORF115 chromosome 1 open reading frame 115
CADM1 cell adhesion molecule 1
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family)
CD14 CD14 molecule
CDK19 cyclin-dependent kinase 19
CES1 carboxylesterase 1
CKS2 CDC28 protein kinase regulatory subunit 2
CORO1A coronin, actin binding protein, 1A
CPD carboxypeptidase D
CPNE3 copine III
CREB3L2 cAMP responsive element binding protein 3-like 2
CRELD2 cysteine-rich with EGF-like domains 2
CRYAB crystallin, alpha B
CXCL13 chemokine (C-X-C motif) ligand 13
DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic)
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15
DYNLT3 dynein, light chain, Tctex-type 3
ELF1 E74-like factor 1 (ets domain transcription factor)
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERBB2 erb-b2 receptor tyrosine kinase 2
ERGIC3 ERGIC and golgi 3
ERMP1 endoplasmic reticulum metallopeptidase 1
FAM171A1 family with sequence similarity 171, member A1
FAM53C family with sequence similarity 53, member C
FASN fatty acid synthase
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FGG fibrinogen gamma chain
FN1 fibronectin 1
FOLR1 folate receptor 1 (adult)
FTH1 ferritin, heavy polypeptide 1
FXR1 fragile X mental retardation, autosomal homolog 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45B growth arrest and DNA-damage-inducible, beta
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GCLC glutamate-cysteine ligase, catalytic subunit
GLUD1 glutamate dehydrogenase 1
GLUL glutamate-ammonia ligase
GPC3 glypican 3
GPM6B glycoprotein M6B
GRB14 growth factor receptor-bound protein 14
GRB7 growth factor receptor-bound protein 7
GSTA1 glutathione S-transferase alpha 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HIST1H2AC histone cluster 1, H2ac
HMOX1 heme oxygenase 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA4L heat shock 70kDa protein 4-like
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IDO1 indoleamine 2,3-dioxygenase 1
IGHMBP2 immunoglobulin mu binding protein 2
IL7R interleukin 7 receptor
KDM5B lysine (K)-specific demethylase 5B
KLHL24 kelch-like family member 24
KRT19 keratin 19, type I
LAMP2 lysosomal-associated membrane protein 2
LPIN2 lipin 2
LPL lipoprotein lipase
LTBP3 latent transforming growth factor beta binding protein 3
MAGED2 melanoma antigen family D2
MAOA monoamine oxidase A
MAOB monoamine oxidase B
MARCH8 membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
METRN meteorin, glial cell differentiation regulator
MLF2 myeloid leukemia factor 2
MME membrane metallo-endopeptidase
MSMB microseminoprotein, beta-
MSMO1 methylsterol monooxygenase 1
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
MYL9 myosin, light chain 9, regulatory
MYO6 myosin VI
NEU1 sialidase 1 (lysosomal sialidase)
NFYA nuclear transcription factor Y, alpha
NR1H2 nuclear receptor subfamily 1, group H, member 2
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9
ODC1 ornithine decarboxylase 1
ORM1 orosomucoid 1
OSER1 oxidative stress responsive serine-rich 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PENK proenkephalin
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLTP phospholipid transfer protein
PPAP2A phosphatidic acid phosphatase type 2A
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRKCZ protein kinase C, zeta
PRSS23 protease, serine, 23
PRUNE prune exopolyphosphatase
PTPRM protein tyrosine phosphatase, receptor type, M
QPRT quinolinate phosphoribosyltransferase
RABGAP1 RAB GTPase activating protein 1
RANBP2 RAN binding protein 2
RBM39 RNA binding motif protein 39
RBP4 retinol binding protein 4, plasma
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RGCC regulator of cell cycle
RNF44 ring finger protein 44
RPN2 ribophorin II
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SEPP1 selenoprotein P, plasma, 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLPI secretory leukocyte peptidase inhibitor
SOS1 son of sevenless homolog 1 (Drosophila)
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TAGLN transgelin
TARP TCR gamma alternate reading frame protein
THBS4 thrombospondin 4
TIMP3 TIMP metallopeptidase inhibitor 3
TSC22D1 TSC22 domain family, member 1
UBQLN2 ubiquilin 2
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGDH UDP-glucose 6-dehydrogenase
USP47 ubiquitin specific peptidase 47
VAV3 vav 3 guanine nucleotide exchange factor
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)
ZC3H11A zinc finger CCCH-type containing 11A
ZFAND5 zinc finger, AN1-type domain 5
ZNF263 zinc finger protein 263

decreased expression

Symbol Name
ADAM19 ADAM metallopeptidase domain 19
ADCY1 adenylate cyclase 1 (brain)
AHR aryl hydrocarbon receptor
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALOX5 arachidonate 5-lipoxygenase
AMIGO2 adhesion molecule with Ig-like domain 2
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARL4C ADP-ribosylation factor-like 4C
ASF1B anti-silencing function 1B histone chaperone
BHLHE40 basic helix-loop-helix family, member e40
BRCA1 breast cancer 1, early onset
C1ORF106 chromosome 1 open reading frame 106
CALML5 calmodulin-like 5
CAPN1 calpain 1, (mu/I) large subunit
CAPN2 calpain 2, (m/II) large subunit
CARD10 caspase recruitment domain family, member 10
CAST calpastatin
CCDC109B coiled-coil domain containing 109B
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCNE2 cyclin E2
CCNF cyclin F
CD24 CD24 molecule
CD44 CD44 molecule (Indian blood group)
CD47 CD47 molecule
CD9 CD9 molecule
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CDCA4 cell division cycle associated 4
CDK14 cyclin-dependent kinase 14
CDK2 cyclin-dependent kinase 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDT1 chromatin licensing and DNA replication factor 1
CENPU centromere protein U
CHAF1A chromatin assembly factor 1, subunit A (p150)
CKLF chemokine-like factor
CLDN3 claudin 3
COTL1 coactosin-like F-actin binding protein 1
CTBP2 C-terminal binding protein 2
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CXCL14 chemokine (C-X-C motif) ligand 14
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHFR dihydrofolate reductase
DPYD dihydropyrimidine dehydrogenase
DPYSL2 dihydropyrimidinase-like 2
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
EDNRA endothelin receptor type A
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EFHD2 EF-hand domain family, member D2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMP1 epithelial membrane protein 1
EPHA2 EPH receptor A2
EPHB2 EPH receptor B2
EREG epiregulin
ESR1 estrogen receptor 1
ETV1 ets variant 1
EXO1 exonuclease 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM57A family with sequence similarity 57, member A
FEN1 flap structure-specific endonuclease 1
FERMT1 fermitin family member 1
FOSL1 FOS-like antigen 1
FXYD5 FXYD domain containing ion transport regulator 5
GATA2 GATA binding protein 2
GGCT gamma-glutamylcyclotransferase
GINS2 GINS complex subunit 2 (Psf2 homolog)
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GNG12 guanine nucleotide binding protein (G protein), gamma 12
GPER1 G protein-coupled estrogen receptor 1
GREM1 gremlin 1, DAN family BMP antagonist
GSTA4 glutathione S-transferase alpha 4
HELLS helicase, lymphoid-specific
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HNMT histamine N-methyltransferase
HOPX HOP homeobox
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IFI16 interferon, gamma-inducible protein 16
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
JUN jun proto-oncogene
KCTD12 potassium channel tetramerization domain containing 12
KDM5D lysine (K)-specific demethylase 5D
KIAA0101 KIAA0101
KIAA0485 uncharacterized LOC57235
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KRT1 keratin 1, type II
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS3 lectin, galactoside-binding, soluble, 3
LIF leukemia inhibitory factor
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LOC100505650 uncharacterized LOC100505650
MACF1 microtubule-actin crosslinking factor 1
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MET MET proto-oncogene, receptor tyrosine kinase
MGLL monoglyceride lipase
MPZL2 myelin protein zero-like 2
MSH2 mutS homolog 2
MUC1 mucin 1, cell surface associated
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYOF myoferlin
NASP nuclear autoantigenic sperm protein (histone-binding)
NR2F2 nuclear receptor subfamily 2, group F, member 2
NT5E 5'-nucleotidase, ecto (CD73)
OIP5 Opa interacting protein 5
OSBPL10 oxysterol binding protein-like 10
PAQR4 progestin and adipoQ receptor family member IV
PCNA proliferating cell nuclear antigen
PCSK1 proprotein convertase subtilisin/kexin type 1
PDE4A phosphodiesterase 4A, cAMP-specific
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PID1 phosphotyrosine interaction domain containing 1
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PNMA2 paraneoplastic Ma antigen 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRDX2 peroxiredoxin 2
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRKCA protein kinase C, alpha
PRKD3 protein kinase D3
PRSS3 protease, serine, 3
PSMC3IP PSMC3 interacting protein
PSPH phosphoserine phosphatase
PTPRD protein tyrosine phosphatase, receptor type, D
PXMP2 peroxisomal membrane protein 2, 22kDa
RAB31 RAB31, member RAS oncogene family
RAD51 RAD51 recombinase
RAP1GAP RAP1 GTPase activating protein
RFC2 replication factor C (activator 1) 2, 40kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RPS4Y1 ribosomal protein S4, Y-linked 1
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RRM1 ribonucleotide reductase M1
S100A6 S100 calcium binding protein A6
SAP30 Sin3A-associated protein, 30kDa
SATB2 SATB homeobox 2
SEPT10 septin 10
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFN stratifin
SH2B3 SH2B adaptor protein 3
SOX9 SRY (sex determining region Y)-box 9
SPON1 spondin 1, extracellular matrix protein
SQRDL sulfide quinone reductase-like (yeast)
SRGN serglycin
STX1A syntaxin 1A (brain)
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TFDP1 transcription factor Dp-1
TFF3 trefoil factor 3 (intestinal)
TGFBI transforming growth factor, beta-induced, 68kDa
TIAM1 T-cell lymphoma invasion and metastasis 1
TK1 thymidine kinase 1, soluble
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TMEM5 transmembrane protein 5
TMSB15A thymosin beta 15a
TNC tenascin C
TOPBP1 topoisomerase (DNA) II binding protein 1
TPSAB1 tryptase alpha/beta 1
TRIB2 tribbles pseudokinase 2
TUBA4A tubulin, alpha 4a
TUBB6 tubulin, beta 6 class V
TYMS thymidylate synthetase
UNG uracil-DNA glycosylase
USP1 ubiquitin specific peptidase 1
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VIM vimentin
WNT5A wingless-type MMTV integration site family, member 5A
WWTR1 WW domain containing transcription regulator 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZCCHC24 zinc finger, CCHC domain containing 24