BRD-A19500257_geldanamycin_HCC515_24_h_0.12_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

83 genes differentially expressed following the BRD-A19500257_geldanamycin_HCC515_24_h_0.12_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIPOR2 adiponectin receptor 2
AGR2 anterior gradient 2
BAG3 BCL2-associated athanogene 3
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CPVL carboxypeptidase, vitellogenic-like
CXCL13 chemokine (C-X-C motif) ligand 13
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
ECHDC2 enoyl CoA hydratase domain containing 2
EIF4B eukaryotic translation initiation factor 4B
EPCAM epithelial cell adhesion molecule
FN1 fibronectin 1
GADD45B growth arrest and DNA-damage-inducible, beta
GATA3 GATA binding protein 3
GCLC glutamate-cysteine ligase, catalytic subunit
GPC3 glypican 3
GSTA1 glutathione S-transferase alpha 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
KRT13 keratin 13, type I
KRT5 keratin 5, type II
LTA4H leukotriene A4 hydrolase
MFGE8 milk fat globule-EGF factor 8 protein
MSMB microseminoprotein, beta-
MXI1 MAX interactor 1, dimerization protein
MXRA5 matrix-remodelling associated 5
MYL9 myosin, light chain 9, regulatory
NXN nucleoredoxin
OSBPL9 oxysterol binding protein-like 9
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
RGS2 regulator of G-protein signaling 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SGK1 serum/glucocorticoid regulated kinase 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
TACSTD2 tumor-associated calcium signal transducer 2
TIMP3 TIMP metallopeptidase inhibitor 3
TOR1A torsin family 1, member A (torsin A)
VCAN versican
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)
ZDHHC11 zinc finger, DHHC-type containing 11
ZKSCAN1 zinc finger with KRAB and SCAN domains 1
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
ADRB2 adrenoceptor beta 2, surface
CCL20 chemokine (C-C motif) ligand 20
CD47 CD47 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CXCR4 chemokine (C-X-C motif) receptor 4
DUSP4 dual specificity phosphatase 4
EPHB2 EPH receptor B2
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FOSL1 FOS-like antigen 1
GATA2 GATA binding protein 2
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GRIA2 glutamate receptor, ionotropic, AMPA 2
IFRD2 interferon-related developmental regulator 2
IGFBP3 insulin-like growth factor binding protein 3
IL13RA2 interleukin 13 receptor, alpha 2
JUN jun proto-oncogene
NPY neuropeptide Y
NT5E 5'-nucleotidase, ecto (CD73)
PFKP phosphofructokinase, platelet
PHLDA2 pleckstrin homology-like domain, family A, member 2
PXMP2 peroxisomal membrane protein 2, 22kDa
RPS4Y1 ribosomal protein S4, Y-linked 1
SAP30 Sin3A-associated protein, 30kDa
SOX9 SRY (sex determining region Y)-box 9
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
STC1 stanniocalcin 1
STX1A syntaxin 1A (brain)
TMSB15A thymosin beta 15a
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TUBA4A tubulin, alpha 4a
ZFP36L2 ZFP36 ring finger protein-like 2