BRD-A19500257_geldanamycin_HCC15_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

90 genes differentially expressed following the BRD-A19500257_geldanamycin_HCC15_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADA adenosine deaminase
ALDOB aldolase B, fructose-bisphosphate
BAG3 BCL2-associated athanogene 3
BPI bactericidal/permeability-increasing protein
CACYBP calcyclin binding protein
CASP7 caspase 7, apoptosis-related cysteine peptidase
CDC42 cell division cycle 42
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CLC Charcot-Leyden crystal galectin
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPAS1 endothelial PAS domain protein 1
GSTT1 glutathione S-transferase theta 1
GUSBP11 glucuronidase, beta pseudogene 11
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HIST1H3H histone cluster 1, H3h
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB1 heat shock 27kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IGLV2-23 immunoglobulin lambda variable 2-23
JCHAIN joining chain of multimeric IgA and IgM
KRT19 keratin 19, type I
LGALS4 lectin, galactoside-binding, soluble, 4
MAPK13 mitogen-activated protein kinase 13
MGAM maltase-glucoamylase
MZB1 marginal zone B and B1 cell-specific protein
NR2F6 nuclear receptor subfamily 2, group F, member 6
OLFM4 olfactomedin 4
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGIS prostaglandin I2 (prostacyclin) synthase
QPRT quinolinate phosphoribosyltransferase
RGS2 regulator of G-protein signaling 2
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SDC1 syndecan 1
SEPP1 selenoprotein P, plasma, 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SPINK1 serine peptidase inhibitor, Kazal type 1
SRSF6 serine/arginine-rich splicing factor 6
SSBP2 single-stranded DNA binding protein 2
SST somatostatin
TFRC transferrin receptor
TMEM97 transmembrane protein 97
TP53I3 tumor protein p53 inducible protein 3
VTCN1 V-set domain containing T cell activation inhibitor 1

decreased expression

Symbol Name
ARL4C ADP-ribosylation factor-like 4C
C2CD5 C2 calcium-dependent domain containing 5
CAST calpastatin
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
DUSP4 dual specificity phosphatase 4
ECM1 extracellular matrix protein 1
GOLGA8A golgin A8 family, member A
GRB14 growth factor receptor-bound protein 14
HES1 hes family bHLH transcription factor 1
IER3 immediate early response 3
IGF1R insulin-like growth factor 1 receptor
MARCKS myristoylated alanine-rich protein kinase C substrate
MPPED2 metallophosphoesterase domain containing 2
NLRP2 NLR family, pyrin domain containing 2
NOLC1 nucleolar and coiled-body phosphoprotein 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
PBX3 pre-B-cell leukemia homeobox 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIP prolactin-induced protein
PODXL podocalyxin-like
PSPH phosphoserine phosphatase
S100A2 S100 calcium binding protein A2
SCD5 stearoyl-CoA desaturase 5
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
ZBTB20 zinc finger and BTB domain containing 20
ZNF185 zinc finger protein 185 (LIM domain)