BRD-A19500257_geldanamycin_HA1E_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

395 genes differentially expressed following the BRD-A19500257_geldanamycin_HA1E_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACKR3 atypical chemokine receptor 3
ADGRG6 adhesion G protein-coupled receptor G6
ADIRF adipogenesis regulatory factor
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
AGR2 anterior gradient 2
AKAP9 A kinase (PRKA) anchor protein 9
ANKRD36B ankyrin repeat domain 36B
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A
AQP3 aquaporin 3 (Gill blood group)
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ASS1 argininosuccinate synthase 1
ATF5 activating transcription factor 5
ATP9A ATPase, class II, type 9A
AURKA aurora kinase A
AXIN1 axin 1
B3GNT1
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BCL6 B-cell CLL/lymphoma 6
BLNK B-cell linker
BRD8 bromodomain containing 8
C14ORF132 chromosome 14 open reading frame 132
C1ORF54 chromosome 1 open reading frame 54
C4BPA complement component 4 binding protein, alpha
C8ORF4 chromosome 8 open reading frame 4
CANX calnexin
CAPN6 calpain 6
CAST calpastatin
CCDC28A coiled-coil domain containing 28A
CCNG1 cyclin G1
CCNG2 cyclin G2
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CEP57 centrosomal protein 57kDa
CGA glycoprotein hormones, alpha polypeptide
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CIT citron rho-interacting serine/threonine kinase
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COBL cordon-bleu WH2 repeat protein
COBLL1 cordon-bleu WH2 repeat protein-like 1
COL21A1 collagen, type XXI, alpha 1
COL3A1 collagen, type III, alpha 1
CPE carboxypeptidase E
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRISP3 cysteine-rich secretory protein 3
DDIT4 DNA-damage-inducible transcript 4
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DPP4 dipeptidyl-peptidase 4
ECHDC2 enoyl CoA hydratase domain containing 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGFL6 EGF-like-domain, multiple 6
EIF4B eukaryotic translation initiation factor 4B
ELANE elastase, neutrophil expressed
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FAM117A family with sequence similarity 117, member A
FAM13A family with sequence similarity 13, member A
FBN2 fibrillin 2
FCGBP Fc fragment of IgG binding protein
FGFR2 fibroblast growth factor receptor 2
FGG fibrinogen gamma chain
FHL1 four and a half LIM domains 1
FLRT3 fibronectin leucine rich transmembrane protein 3
FMO3 flavin containing monooxygenase 3
FRY furry homolog (Drosophila)
FXR1 fragile X mental retardation, autosomal homolog 1
FZD5 frizzled class receptor 5
GABARAPL1 GABA(A) receptor-associated protein like 1
GAS1 growth arrest-specific 1
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLTSCR2 glioma tumor suppressor candidate region gene 2
GLUL glutamate-ammonia ligase
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
GOLGB1 golgin B1
GPM6B glycoprotein M6B
GPX3 glutathione peroxidase 3
HAL histidine ammonia-lyase
HBB hemoglobin, beta
HECA headcase homolog (Drosophila)
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HMGB2 high mobility group box 2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IFIH1 interferon induced with helicase C domain 1
INSR insulin receptor
ITPKB inositol-trisphosphate 3-kinase B
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCNK1 potassium channel, two pore domain subfamily K, member 1
KIF11 kinesin family member 11
KIF2C kinesin family member 2C
KLHL24 kelch-like family member 24
LAMP3 lysosomal-associated membrane protein 3
LETMD1 LETM1 domain containing 1
LIMCH1 LIM and calponin homology domains 1
LITAF lipopolysaccharide-induced TNF factor
LMO3 LIM domain only 3 (rhombotin-like 2)
LRRC1 leucine rich repeat containing 1
LTA4H leukotriene A4 hydrolase
LTF lactotransferrin
LYZ lysozyme
MAOA monoamine oxidase A
MAOB monoamine oxidase B
MBNL2 muscleblind-like splicing regulator 2
METTL7A methyltransferase like 7A
MSMB microseminoprotein, beta-
MTUS1 microtubule associated tumor suppressor 1
MXI1 MAX interactor 1, dimerization protein
MYH10 myosin, heavy chain 10, non-muscle
N4BP2L1 NEDD4 binding protein 2-like 1
NAV2 neuron navigator 2
NEBL nebulette
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NISCH nischarin
NNT nicotinamide nucleotide transhydrogenase
OLFM1 olfactomedin 1
PBX1 pre-B-cell leukemia homeobox 1
PCDH17 protocadherin 17
PCP4 Purkinje cell protein 4
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1
PECR peroxisomal trans-2-enoyl-CoA reductase
PFDN5 prefoldin subunit 5
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PKP4 plakophilin 4
PLA2G16 phospholipase A2, group XVI
PPL periplakin
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PTK2B protein tyrosine kinase 2 beta
PTOV1 prostate tumor overexpressed 1
QKI QKI, KH domain containing, RNA binding
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAD21 RAD21 homolog (S. pombe)
RALBP1 ralA binding protein 1
RAP1GAP RAP1 GTPase activating protein
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RPL28 ribosomal protein L28
RSAD2 radical S-adenosyl methionine domain containing 2
S100A8 S100 calcium binding protein A8
SCUBE2 signal peptide, CUB domain, EGF-like 2
SFTPA2 surfactant protein A2
SIK1 salt-inducible kinase 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SLC38A2 solute carrier family 38, member 2
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLPI secretory leukocyte peptidase inhibitor
SPARCL1 SPARC-like 1 (hevin)
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SRGN serglycin
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STK24 serine/threonine kinase 24
STOM stomatin
STON1 stonin 1
STS steroid sulfatase (microsomal), isozyme S
SYNE1 spectrin repeat containing, nuclear envelope 1
TBC1D15 TBC1 domain family, member 15
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TESC tescalcin
TMC5 transmembrane channel-like 5
TMSB15A thymosin beta 15a
TNNT1 troponin T type 1 (skeletal, slow)
TOB1 transducer of ERBB2, 1
TPBG trophoblast glycoprotein
TPD52 tumor protein D52
TSPAN13 tetraspanin 13
TSPYL5 TSPY-like 5
TXNIP thioredoxin interacting protein
UTP14C UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast)
WBP1L WW domain binding protein 1-like
WFDC1 WAP four-disulfide core domain 1
WFS1 Wolfram syndrome 1 (wolframin)
WSB1 WD repeat and SOCS box containing 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ACLY ATP citrate lyase
ADAM12 ADAM metallopeptidase domain 12
ADGRG1 adhesion G protein-coupled receptor G1
ADM adrenomedullin
AGA aspartylglucosaminidase
AK4 adenylate kinase 4
AKAP12 A kinase (PRKA) anchor protein 12
ALB albumin
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMDHD2 amidohydrolase domain containing 2
AMIGO2 adhesion molecule with Ig-like domain 2
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
ANPEP alanyl (membrane) aminopeptidase
APRT adenine phosphoribosyltransferase
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40
ARL4A ADP-ribosylation factor-like 4A
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
ATP5G1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
AXL AXL receptor tyrosine kinase
BGN biglycan
BHLHE40 basic helix-loop-helix family, member e40
BID BH3 interacting domain death agonist
BIRC2 baculoviral IAP repeat containing 2
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BOP1 block of proliferation 1
C3 complement component 3
CALML5 calmodulin-like 5
CAPN2 calpain 2, (m/II) large subunit
CCDC86 coiled-coil domain containing 86
CCL2 chemokine (C-C motif) ligand 2
CCND1 cyclin D1
CCR7 chemokine (C-C motif) receptor 7
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CFLAR CASP8 and FADD-like apoptosis regulator
CH25H cholesterol 25-hydroxylase
COL10A1 collagen, type X, alpha 1
COL14A1 collagen, type XIV, alpha 1
COL1A1 collagen, type I, alpha 1
COL6A2 collagen, type VI, alpha 2
COMP cartilage oligomeric matrix protein
COPS7A COP9 signalosome subunit 7A
CTGF connective tissue growth factor
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYTH1 cytohesin 1
DLC1 DLC1 Rho GTPase activating protein
DLX2 distal-less homeobox 2
DPYSL3 dihydropyrimidinase-like 3
DSP desmoplakin
DUSP10 dual specificity phosphatase 10
DUSP5 dual specificity phosphatase 5
DUSP7 dual specificity phosphatase 7
EDN1 endothelin 1
EGLN3 egl-9 family hypoxia-inducible factor 3
EGR1 early growth response 1
EGR3 early growth response 3
EIF5A eukaryotic translation initiation factor 5A
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMG1 EMG1 N1-specific pseudouridine methyltransferase
EMP1 epithelial membrane protein 1
ENO1 enolase 1, (alpha)
EPHA2 EPH receptor A2
EPHB2 EPH receptor B2
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
F13A1 coagulation factor XIII, A1 polypeptide
FABP1 fatty acid binding protein 1, liver
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FAM216A family with sequence similarity 216, member A
FBN1 fibrillin 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FZD7 frizzled class receptor 7
GADD45A growth arrest and DNA-damage-inducible, alpha
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GLIPR1 GLI pathogenesis-related 1
GRB10 growth factor receptor-bound protein 10
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HMOX2 heme oxygenase 2
HN1 hematological and neurological expressed 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IGFBP3 insulin-like growth factor binding protein 3
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IL32 interleukin 32
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
ITGAV integrin, alpha V
JAG1 jagged 1
JUN jun proto-oncogene
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KIAA0226L KIAA0226-like
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KRT10 keratin 10, type I
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LAPTM4B lysosomal protein transmembrane 4 beta
LDLR low density lipoprotein receptor
LIF leukemia inhibitory factor
LMCD1 LIM and cysteine-rich domains 1
LMNA lamin A/C
LOX lysyl oxidase
LOXL1 lysyl oxidase-like 1
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAP1B microtubule-associated protein 1B
MAP7 microtubule-associated protein 7
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MCL1 myeloid cell leukemia 1
MEX3D mex-3 RNA binding family member D
MMP2 matrix metallopeptidase 2
MOK MOK protein kinase
MRPL12 mitochondrial ribosomal protein L12
MRPL24 mitochondrial ribosomal protein L24
MTERF3 mitochondrial transcription termination factor 3
MVP major vault protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NEFL neurofilament, light polypeptide
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NKX3-1 NK3 homeobox 1
NOP16 NOP16 nucleolar protein
NRG1 neuregulin 1
PDAP1 PDGFA associated protein 1
PDGFC platelet derived growth factor C
PDLIM2 PDZ and LIM domain 2 (mystique)
PEA15 phosphoprotein enriched in astrocytes 15
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PMEPA1 prostate transmembrane protein, androgen induced 1
PNP purine nucleoside phosphorylase
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
PPIF peptidylprolyl isomerase F
PRKCA protein kinase C, alpha
PRMT3 protein arginine methyltransferase 3
PRSS2 protease, serine, 2 (trypsin 2)
PTHLH parathyroid hormone-like hormone
PTX3 pentraxin 3, long
PUS7 pseudouridylate synthase 7 (putative)
QPCT glutaminyl-peptide cyclotransferase
RAB32 RAB32, member RAS oncogene family
RBP1 retinol binding protein 1, cellular
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RFTN1 raftlin, lipid raft linker 1
RHOC ras homolog family member C
RPIA ribose 5-phosphate isomerase A
RPP40 ribonuclease P/MRP 40kDa subunit
RRAD Ras-related associated with diabetes
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RUNX1 runt-related transcription factor 1
S100A2 S100 calcium binding protein A2
SATB2 SATB homeobox 2
SDC4 syndecan 4
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFN stratifin
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SNAI2 snail family zinc finger 2
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPHK1 sphingosine kinase 1
SPRY4 sprouty homolog 4 (Drosophila)
SRM spermidine synthase
SRPX2 sushi-repeat containing protein, X-linked 2
STK17A serine/threonine kinase 17a
TAGLN2 transgelin 2
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TGFA transforming growth factor, alpha
TGFBI transforming growth factor, beta-induced, 68kDa
THBS1 thrombospondin 1
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF1 transmembrane 4 L six family member 1
TNC tenascin C
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TPM1 tropomyosin 1 (alpha)
TRIB2 tribbles pseudokinase 2
TUBB2A tubulin, beta 2A class IIa
TXNDC9 thioredoxin domain containing 9
UPP1 uridine phosphorylase 1
VCAN versican
WSB2 WD repeat and SOCS box containing 2
WT1 Wilms tumor 1