BRD-A19500257_geldanamycin_HA1E_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

346 genes differentially expressed following the BRD-A19500257_geldanamycin_HA1E_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ADGRG6 adhesion G protein-coupled receptor G6
AGR2 anterior gradient 2
ANKRD12 ankyrin repeat domain 12
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
APOC1 apolipoprotein C-I
APOE apolipoprotein E
AQP4 aquaporin 4
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
ATP9A ATPase, class II, type 9A
AURKA aurora kinase A
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
C3AR1 complement component 3a receptor 1
C8ORF4 chromosome 8 open reading frame 4
CA11 carbonic anhydrase XI
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCDC28A coiled-coil domain containing 28A
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCNG1 cyclin G1
CCNG2 cyclin G2
CD14 CD14 molecule
CD163 CD163 molecule
CD9 CD9 molecule
CDK19 cyclin-dependent kinase 19
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CENPE centromere protein E, 312kDa
CFI complement factor I
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CNPY3 canopy FGF signaling regulator 3
COBL cordon-bleu WH2 repeat protein
COCH cochlin
COL2A1 collagen, type II, alpha 1
COL3A1 collagen, type III, alpha 1
CP ceruloplasmin (ferroxidase)
CPM carboxypeptidase M
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CXADR coxsackie virus and adenovirus receptor
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL9 chemokine (C-X-C motif) ligand 9
CYFIP1 cytoplasmic FMR1 interacting protein 1
DAPK1 death-associated protein kinase 1
DCAF16 DDB1 and CUL4 associated factor 16
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF4B eukaryotic translation initiation factor 4B
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FAM117A family with sequence similarity 117, member A
FAM13A family with sequence similarity 13, member A
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCGBP Fc fragment of IgG binding protein
FGFR2 fibroblast growth factor receptor 2
FGG fibrinogen gamma chain
FRMD4B FERM domain containing 4B
FRY furry homolog (Drosophila)
FXR1 fragile X mental retardation, autosomal homolog 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GATA3 GATA binding protein 3
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GLDC glycine dehydrogenase (decarboxylating)
GLTSCR2 glioma tumor suppressor candidate region gene 2
GLUL glutamate-ammonia ligase
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
GNLY granulysin
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HBB hemoglobin, beta
HEBP1 heme binding protein 1
HECA headcase homolog (Drosophila)
HMGB2 high mobility group box 2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IDO1 indoleamine 2,3-dioxygenase 1
IFITM1 interferon induced transmembrane protein 1
IFNG interferon, gamma
IGHMBP2 immunoglobulin mu binding protein 2
JADE2 jade family PHD finger 2
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCTD14 potassium channel tetramerization domain containing 14
KDM5D lysine (K)-specific demethylase 5D
KIF2C kinesin family member 2C
KLHL24 kelch-like family member 24
LAMP3 lysosomal-associated membrane protein 3
LIMCH1 LIM and calponin homology domains 1
LITAF lipopolysaccharide-induced TNF factor
LRRC1 leucine rich repeat containing 1
LTF lactotransferrin
LY6E lymphocyte antigen 6 complex, locus E
LYZ lysozyme
MAOA monoamine oxidase A
MAOB monoamine oxidase B
MBNL2 muscleblind-like splicing regulator 2
MBP myelin basic protein
METTL7A methyltransferase like 7A
MMP9 matrix metallopeptidase 9
MNDA myeloid cell nuclear differentiation antigen
MTUS1 microtubule associated tumor suppressor 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYO5C myosin VC
NBEA neurobeachin
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NELL2 NEL-like 2 (chicken)
NISCH nischarin
NNAT neuronatin
NNT nicotinamide nucleotide transhydrogenase
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NYNRIN NYN domain and retroviral integrase containing
P3H2 prolyl 3-hydroxylase 2
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PBX1 pre-B-cell leukemia homeobox 1
PDE4D phosphodiesterase 4D, cAMP-specific
PDE8B phosphodiesterase 8B
PEG3 paternally expressed 3
PERP PERP, TP53 apoptosis effector
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLA2G16 phospholipase A2, group XVI
PRC1 protein regulator of cytokinesis 1
PROM1 prominin 1
PTK2B protein tyrosine kinase 2 beta
PTOV1 prostate tumor overexpressed 1
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RAD21 RAD21 homolog (S. pombe)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RCAN2 regulator of calcineurin 2
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SEPP1 selenoprotein P, plasma, 1
SFTPA2 surfactant protein A2
SFTPD surfactant protein D
SIK1 salt-inducible kinase 1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLPI secretory leukocyte peptidase inhibitor
SPP1 secreted phosphoprotein 1
SYNE1 spectrin repeat containing, nuclear envelope 1
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2
TARP TCR gamma alternate reading frame protein
TBC1D2B TBC1 domain family, member 2B
TESC tescalcin
TMC5 transmembrane channel-like 5
TMEM97 transmembrane protein 97
TPM4 tropomyosin 4
TRIM28 tripartite motif containing 28
TSPAN13 tetraspanin 13
TSPYL5 TSPY-like 5
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VGLL1 vestigial-like family member 1
VWA5A von Willebrand factor A domain containing 5A
WFDC1 WAP four-disulfide core domain 1
WFDC2 WAP four-disulfide core domain 2
WFS1 Wolfram syndrome 1 (wolframin)
XCL1 chemokine (C motif) ligand 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ADAM12 ADAM metallopeptidase domain 12
ADGRG1 adhesion G protein-coupled receptor G1
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
AK4 adenylate kinase 4
ALB albumin
ALCAM activated leukocyte cell adhesion molecule
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMDHD2 amidohydrolase domain containing 2
AMIGO2 adhesion molecule with Ig-like domain 2
ANPEP alanyl (membrane) aminopeptidase
ANXA1 annexin A1
AOX1 aldehyde oxidase 1
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40
ATP5G1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
AXL AXL receptor tyrosine kinase
BGN biglycan
BHLHE40 basic helix-loop-helix family, member e40
BIRC2 baculoviral IAP repeat containing 2
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
C3 complement component 3
C6ORF62 chromosome 6 open reading frame 62
CCDC85B coiled-coil domain containing 85B
CCL2 chemokine (C-C motif) ligand 2
CCND1 cyclin D1
CD36 CD36 molecule (thrombospondin receptor)
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CECR1 cat eye syndrome chromosome region, candidate 1
CEP170 centrosomal protein 170kDa
CFLAR CASP8 and FADD-like apoptosis regulator
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
COL6A2 collagen, type VI, alpha 2
COMP cartilage oligomeric matrix protein
CPE carboxypeptidase E
CREB1 cAMP responsive element binding protein 1
CTGF connective tissue growth factor
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
CYCS cytochrome c, somatic
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
CYTH1 cytohesin 1
DACT1 dishevelled-binding antagonist of beta-catenin 1
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DLX2 distal-less homeobox 2
DOK5 docking protein 5
DUSP6 dual specificity phosphatase 6
EFNB2 ephrin-B2
EGR1 early growth response 1
EGR3 early growth response 3
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EIF5 eukaryotic translation initiation factor 5
EIF5A eukaryotic translation initiation factor 5A
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMG1 EMG1 N1-specific pseudouridine methyltransferase
EMP1 epithelial membrane protein 1
EPHA2 EPH receptor A2
EPHB2 EPH receptor B2
EREG epiregulin
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FBN1 fibrillin 1
FOSL1 FOS-like antigen 1
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GADD45B growth arrest and DNA-damage-inducible, beta
GATA2 GATA binding protein 2
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GLIPR1 GLI pathogenesis-related 1
GLS glutaminase
GREM1 gremlin 1, DAN family BMP antagonist
HAPLN1 hyaluronan and proteoglycan link protein 1
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFRD2 interferon-related developmental regulator 2
IGFBP3 insulin-like growth factor binding protein 3
IL32 interleukin 32
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
ISG15 ISG15 ubiquitin-like modifier
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
JAG1 jagged 1
JUN jun proto-oncogene
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KRT10 keratin 10, type I
KRT23 keratin 23, type I
LIF leukemia inhibitory factor
LIN28A lin-28 homolog A (C. elegans)
LMCD1 LIM and cysteine-rich domains 1
LMNA lamin A/C
LOX lysyl oxidase
LRP4 low density lipoprotein receptor-related protein 4
MAP1B microtubule-associated protein 1B
MARCKS myristoylated alanine-rich protein kinase C substrate
MCL1 myeloid cell leukemia 1
MFAP5 microfibrillar associated protein 5
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMP2 matrix metallopeptidase 2
MOK MOK protein kinase
MRPL24 mitochondrial ribosomal protein L24
MT1X metallothionein 1X
MT2A metallothionein 2A
MTSS1 metastasis suppressor 1
NPTX2 neuronal pentraxin II
NREP neuronal regeneration related protein
NRG1 neuregulin 1
PDGFA platelet-derived growth factor alpha polypeptide
PDGFC platelet derived growth factor C
PDLIM2 PDZ and LIM domain 2 (mystique)
PFKP phosphofructokinase, platelet
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAGL1 pleiomorphic adenoma gene-like 1
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PMEPA1 prostate transmembrane protein, androgen induced 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POSTN periostin, osteoblast specific factor
PRKCA protein kinase C, alpha
PTX3 pentraxin 3, long
PUS7 pseudouridylate synthase 7 (putative)
RGS4 regulator of G-protein signaling 4
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RRAD Ras-related associated with diabetes
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SATB2 SATB homeobox 2
SCG5 secretogranin V
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERTAD2 SERTA domain containing 2
SNAI2 snail family zinc finger 2
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPHK1 sphingosine kinase 1
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SRM spermidine synthase
SRPX sushi-repeat containing protein, X-linked
SRPX2 sushi-repeat containing protein, X-linked 2
STK10 serine/threonine kinase 10
STK17A serine/threonine kinase 17a
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TGFA transforming growth factor, alpha
TGFBI transforming growth factor, beta-induced, 68kDa
THBS1 thrombospondin 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TNC tenascin C
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TP53I3 tumor protein p53 inducible protein 3
TPM1 tropomyosin 1 (alpha)
TSPAN7 tetraspanin 7
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
TUBB3 tubulin, beta 3 class III
TXNDC9 thioredoxin domain containing 9
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2E3 ubiquitin-conjugating enzyme E2E 3
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
UPP1 uridine phosphorylase 1
VCAN versican
WSB2 WD repeat and SOCS box containing 2
XIST X inactive specific transcript (non-protein coding)
ZNF593 zinc finger protein 593