BRD-A19500257_geldanamycin_HA1E_24_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

353 genes differentially expressed following the BRD-A19500257_geldanamycin_HA1E_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ADGRG2 adhesion G protein-coupled receptor G2
ADGRG6 adhesion G protein-coupled receptor G6
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
AGR2 anterior gradient 2
ANXA10 annexin A10
ARMCX1 armadillo repeat containing, X-linked 1
ASCL1 achaete-scute family bHLH transcription factor 1
ASS1 argininosuccinate synthase 1
ATP9A ATPase, class II, type 9A
AURKA aurora kinase A
BCL6 B-cell CLL/lymphoma 6
BMP4 bone morphogenetic protein 4
C1ORF54 chromosome 1 open reading frame 54
C8ORF4 chromosome 8 open reading frame 4
CASP7 caspase 7, apoptosis-related cysteine peptidase
CAST calpastatin
CCDC28A coiled-coil domain containing 28A
CCNA1 cyclin A1
CCNG1 cyclin G1
CD14 CD14 molecule
CD163 CD163 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD9 CD9 molecule
CDK19 cyclin-dependent kinase 19
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CENPE centromere protein E, 312kDa
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLDN18 claudin 18
CLEC11A C-type lectin domain family 11, member A
COBL cordon-bleu WH2 repeat protein
COL21A1 collagen, type XXI, alpha 1
COL3A1 collagen, type III, alpha 1
CRISP3 cysteine-rich secretory protein 3
CXCL13 chemokine (C-X-C motif) ligand 13
CXCR4 chemokine (C-X-C motif) receptor 4
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DPP4 dipeptidyl-peptidase 4
ECHDC2 enoyl CoA hydratase domain containing 2
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EIF4B eukaryotic translation initiation factor 4B
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPCAM epithelial cell adhesion molecule
EPHA4 EPH receptor A4
ESR1 estrogen receptor 1
EYA2 EYA transcriptional coactivator and phosphatase 2
FAM134B family with sequence similarity 134, member B
FCGBP Fc fragment of IgG binding protein
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FGFR2 fibroblast growth factor receptor 2
FPR1 formyl peptide receptor 1
FRY furry homolog (Drosophila)
FXR1 fragile X mental retardation, autosomal homolog 1
FZD5 frizzled class receptor 5
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GALC galactosylceramidase
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GLTSCR2 glioma tumor suppressor candidate region gene 2
GLUL glutamate-ammonia ligase
GOLGB1 golgin B1
GPM6B glycoprotein M6B
GRAMD1C GRAM domain containing 1C
GSTZ1 glutathione S-transferase zeta 1
HBB hemoglobin, beta
HECA headcase homolog (Drosophila)
HLA-E major histocompatibility complex, class I, E
HMGB2 high mobility group box 2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IDO1 indoleamine 2,3-dioxygenase 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGHMBP2 immunoglobulin mu binding protein 2
IL1B interleukin 1, beta
IL1R2 interleukin 1 receptor, type II
IQCG IQ motif containing G
ITFG1 integrin alpha FG-GAP repeat containing 1
ITPKB inositol-trisphosphate 3-kinase B
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KDM5D lysine (K)-specific demethylase 5D
KIF20A kinesin family member 20A
KIZ kizuna centrosomal protein
KLF5 Kruppel-like factor 5 (intestinal)
KRT13 keratin 13, type I
LAMP3 lysosomal-associated membrane protein 3
LETMD1 LETM1 domain containing 1
LITAF lipopolysaccharide-induced TNF factor
LRRC1 leucine rich repeat containing 1
LTA4H leukotriene A4 hydrolase
LTF lactotransferrin
LY6E lymphocyte antigen 6 complex, locus E
MAOA monoamine oxidase A
MCAM melanoma cell adhesion molecule
MME membrane metallo-endopeptidase
MMP9 matrix metallopeptidase 9
MTUS1 microtubule associated tumor suppressor 1
MYO5C myosin VC
MYO6 myosin VI
NCAPD2 non-SMC condensin I complex, subunit D2
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NELL2 NEL-like 2 (chicken)
NISCH nischarin
NME5 NME/NM23 family member 5
NNT nicotinamide nucleotide transhydrogenase
NUSAP1 nucleolar and spindle associated protein 1
OGDHL oxoglutarate dehydrogenase-like
P3H2 prolyl 3-hydroxylase 2
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PBX1 pre-B-cell leukemia homeobox 1
PCDH17 protocadherin 17
PCP4 Purkinje cell protein 4
PFDN5 prefoldin subunit 5
PFKM phosphofructokinase, muscle
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PLA2G16 phospholipase A2, group XVI
PSCA prostate stem cell antigen
PTK2B protein tyrosine kinase 2 beta
PTOV1 prostate tumor overexpressed 1
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RAD21 RAD21 homolog (S. pombe)
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RPS5 ribosomal protein S5
S100A8 S100 calcium binding protein A8
SCGB2A1 secretoglobin, family 2A, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SELENBP1 selenium binding protein 1
SFTPC surfactant protein C
SIK1 salt-inducible kinase 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC46A3 solute carrier family 46, member 3
SLPI secretory leukocyte peptidase inhibitor
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TCTN1 tectonic family member 1
TPBG trophoblast glycoprotein
TSPYL5 TSPY-like 5
UTP14C UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast)
WFDC2 WAP four-disulfide core domain 2
WFS1 Wolfram syndrome 1 (wolframin)
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ACLY ATP citrate lyase
ADAM12 ADAM metallopeptidase domain 12
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADGRG1 adhesion G protein-coupled receptor G1
AHNAK2 AHNAK nucleoprotein 2
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
AK4 adenylate kinase 4
AKAP12 A kinase (PRKA) anchor protein 12
ALB albumin
ALCAM activated leukocyte cell adhesion molecule
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMDHD2 amidohydrolase domain containing 2
AMIGO2 adhesion molecule with Ig-like domain 2
ANPEP alanyl (membrane) aminopeptidase
ANXA1 annexin A1
AP2B1 adaptor-related protein complex 2, beta 1 subunit
AREG amphiregulin
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40
ASPN asporin
ATP5G1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
AXL AXL receptor tyrosine kinase
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BZW1 basic leucine zipper and W2 domains 1
C3 complement component 3
C6ORF62 chromosome 6 open reading frame 62
CCL2 chemokine (C-C motif) ligand 2
CCR7 chemokine (C-C motif) receptor 7
CD24 CD24 molecule
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEP170 centrosomal protein 170kDa
CFD complement factor D (adipsin)
CLEC2B C-type lectin domain family 2, member B
COL14A1 collagen, type XIV, alpha 1
COL1A1 collagen, type I, alpha 1
COL6A2 collagen, type VI, alpha 2
COL9A3 collagen, type IX, alpha 3
COMP cartilage oligomeric matrix protein
CPE carboxypeptidase E
CREB1 cAMP responsive element binding protein 1
CRIP2 cysteine-rich protein 2
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYTH1 cytohesin 1
CYTL1 cytokine-like 1
DACT1 dishevelled-binding antagonist of beta-catenin 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLX2 distal-less homeobox 2
DPYSL3 dihydropyrimidinase-like 3
DSE dermatan sulfate epimerase
DSP desmoplakin
DUSP10 dual specificity phosphatase 10
DUSP22 dual specificity phosphatase 22
ECM1 extracellular matrix protein 1
EGR1 early growth response 1
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EIF5 eukaryotic translation initiation factor 5
EIF5A eukaryotic translation initiation factor 5A
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMP1 epithelial membrane protein 1
EPHB2 EPH receptor B2
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FABP1 fatty acid binding protein 1, liver
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM216A family with sequence similarity 216, member A
FBN1 fibrillin 1
FOSL1 FOS-like antigen 1
FZD7 frizzled class receptor 7
G0S2 G0/G1 switch 2
GADD45B growth arrest and DNA-damage-inducible, beta
GAL galanin/GMAP prepropeptide
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GLIPR1 GLI pathogenesis-related 1
GLS glutaminase
GNAS GNAS complex locus
GRB10 growth factor receptor-bound protein 10
GREM1 gremlin 1, DAN family BMP antagonist
HES1 hes family bHLH transcription factor 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HMOX2 heme oxygenase 2
HN1 hematological and neurological expressed 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IFRD2 interferon-related developmental regulator 2
IGFBP3 insulin-like growth factor binding protein 3
IGFBP6 insulin-like growth factor binding protein 6
IGHM immunoglobulin heavy constant mu
IL32 interleukin 32
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
ITGAV integrin, alpha V
ITM2A integral membrane protein 2A
JAG1 jagged 1
JUN jun proto-oncogene
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLF7 Kruppel-like factor 7 (ubiquitous)
KRT10 keratin 10, type I
KRT14 keratin 14, type I
KRT6B keratin 6B, type II
LAPTM4B lysosomal protein transmembrane 4 beta
LIF leukemia inhibitory factor
LMCD1 LIM and cysteine-rich domains 1
LOX lysyl oxidase
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MALL mal, T-cell differentiation protein-like
MAP1B microtubule-associated protein 1B
MARCKSL1 MARCKS-like 1
MCL1 myeloid cell leukemia 1
MFAP5 microfibrillar associated protein 5
MOK MOK protein kinase
MT1X metallothionein 1X
MTSS1 metastasis suppressor 1
MYO1B myosin IB
NEFL neurofilament, light polypeptide
NKX3-1 NK3 homeobox 1
NOP16 NOP16 nucleolar protein
NREP neuronal regeneration related protein
NTM neurotrimin
PDGFC platelet derived growth factor C
PDGFD platelet derived growth factor D
PDZK1IP1 PDZK1 interacting protein 1
PFKP phosphofructokinase, platelet
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAGL1 pleiomorphic adenoma gene-like 1
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PMEPA1 prostate transmembrane protein, androgen induced 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
PRKCA protein kinase C, alpha
PUS7 pseudouridylate synthase 7 (putative)
RBP1 retinol binding protein 1, cellular
REG3A regenerating islet-derived 3 alpha
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RUFY3 RUN and FYVE domain containing 3
RUNX1 runt-related transcription factor 1
S100A2 S100 calcium binding protein A2
SATB2 SATB homeobox 2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SNAI2 snail family zinc finger 2
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPHK1 sphingosine kinase 1
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SRM spermidine synthase
SRPX sushi-repeat containing protein, X-linked
STK10 serine/threonine kinase 10
STK17A serine/threonine kinase 17a
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TGFBI transforming growth factor, beta-induced, 68kDa
THBS2 thrombospondin 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TNC tenascin C
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRBC1 T cell receptor beta constant 1
TSC22D2 TSC22 domain family, member 2
TSPAN7 tetraspanin 7
TUBA4A tubulin, alpha 4a
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
TUBB6 tubulin, beta 6 class V
UBE2E3 ubiquitin-conjugating enzyme E2E 3
UPP1 uridine phosphorylase 1
VAT1 vesicle amine transport 1
VCAN versican
VEGFC vascular endothelial growth factor C
XIST X inactive specific transcript (non-protein coding)
ZFP36L1 ZFP36 ring finger protein-like 1
ZMIZ1 zinc finger, MIZ-type containing 1