BRD-A19500257_geldanamycin_DV90_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

150 genes differentially expressed following the BRD-A19500257_geldanamycin_DV90_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGR2 anterior gradient 2
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
AMIGO2 adhesion molecule with Ig-like domain 2
AQP1 aquaporin 1 (Colton blood group)
AZGP1 alpha-2-glycoprotein 1, zinc-binding
B9D1 B9 protein domain 1
BAG3 BCL2-associated athanogene 3
BLNK B-cell linker
CALR calreticulin
CANX calnexin
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLDN10 claudin 10
COL15A1 collagen, type XV, alpha 1
CTGF connective tissue growth factor
CYTIP cytohesin 1 interacting protein
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DPP4 dipeptidyl-peptidase 4
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
FHL1 four and a half LIM domains 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPE1 heat shock 10kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
HYOU1 hypoxia up-regulated 1
IGF1 insulin-like growth factor 1 (somatomedin C)
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIAA0355 KIAA0355
KRT18 keratin 18, type I
KRT19 keratin 19, type I
KRT7 keratin 7, type II
MAP7 microtubule-associated protein 7
MBNL2 muscleblind-like splicing regulator 2
MBOAT7 membrane bound O-acyltransferase domain containing 7
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MMP1 matrix metallopeptidase 1
MSMB microseminoprotein, beta-
NEB nebulin
NNT nicotinamide nucleotide transhydrogenase
NUPR1 nuclear protein, transcriptional regulator, 1
P2RY14 purinergic receptor P2Y, G-protein coupled, 14
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDIA4 protein disulfide isomerase family A, member 4
PDIA6 protein disulfide isomerase family A, member 6
PEG3 paternally expressed 3
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PTGIS prostaglandin I2 (prostacyclin) synthase
QPCT glutaminyl-peptide cyclotransferase
RHOQ ras homolog family member Q
RNASE6 ribonuclease, RNase A family, k6
SCRG1 stimulator of chondrogenesis 1
SELL selectin L
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SESN1 sestrin 1
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SGK1 serum/glucocorticoid regulated kinase 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC35B1 solute carrier family 35, member B1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX2 SRY (sex determining region Y)-box 2
THBS2 thrombospondin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM5 transmembrane protein 5
TRAK2 trafficking protein, kinesin binding 2
UBE2H ubiquitin-conjugating enzyme E2H
UFL1 UFM1-specific ligase 1
VGLL1 vestigial-like family member 1
ZBTB38 zinc finger and BTB domain containing 38

decreased expression

Symbol Name
ACD adrenocortical dysplasia homolog (mouse)
AFP alpha-fetoprotein
ATHL1 ATH1, acid trehalase-like 1 (yeast)
AURKA aurora kinase A
BASP1 brain abundant, membrane attached signal protein 1
BMP4 bone morphogenetic protein 4
CCL20 chemokine (C-C motif) ligand 20
CCL21 chemokine (C-C motif) ligand 21
CDA cytidine deaminase
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
COCH cochlin
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYC1 cytochrome c-1
EREG epiregulin
FABP1 fatty acid binding protein 1, liver
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FGFR2 fibroblast growth factor receptor 2
GPRC5A G protein-coupled receptor, class C, group 5, member A
IER3 immediate early response 3
IFITM2 interferon induced transmembrane protein 2
KLF10 Kruppel-like factor 10
KLF6 Kruppel-like factor 6
LBR lamin B receptor
LCN2 lipocalin 2
LDLR low density lipoprotein receptor
LMO2 LIM domain only 2 (rhombotin-like 1)
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MALL mal, T-cell differentiation protein-like
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MFSD10 major facilitator superfamily domain containing 10
MT1E metallothionein 1E
MT1H metallothionein 1H
MT1X metallothionein 1X
MT2A metallothionein 2A
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR2F6 nuclear receptor subfamily 2, group F, member 6
NRN1 neuritin 1
PI3 peptidase inhibitor 3, skin-derived
PLAT plasminogen activator, tissue
PRSS3 protease, serine, 3
PTGDS prostaglandin D2 synthase 21kDa (brain)
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCO2 SCO2 cytochrome c oxidase assembly protein
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SFN stratifin
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SMAD1 SMAD family member 1
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
STK25 serine/threonine kinase 25
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMSB15A thymosin beta 15a
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRAPPC3 trafficking protein particle complex 3
TUBB3 tubulin, beta 3 class III
ZBTB18 zinc finger and BTB domain containing 18