BRD-A19500257_geldanamycin_BT20_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

106 genes differentially expressed following the BRD-A19500257_geldanamycin_BT20_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
BAG3 BCL2-associated athanogene 3
CALR calreticulin
CDK2AP2 cyclin-dependent kinase 2 associated protein 2
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CRELD2 cysteine-rich with EGF-like domains 2
CST3 cystatin C
CXCL13 chemokine (C-X-C motif) ligand 13
DDIT3 DNA-damage-inducible transcript 3
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP2 dual specificity phosphatase 2
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
FKBP11 FK506 binding protein 11, 19 kDa
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GUSBP11 glucuronidase, beta pseudogene 11
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
HYOU1 hypoxia up-regulated 1
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV3-20 immunoglobulin kappa variable 3-20
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IGLV1-40 immunoglobulin lambda variable 1-40
IGLV2-23 immunoglobulin lambda variable 2-23
IGLV3-19 immunoglobulin lambda variable 3-19
JMJD6 jumonji domain containing 6
LIMA1 LIM domain and actin binding 1
LRRC59 leucine rich repeat containing 59
MANF mesencephalic astrocyte-derived neurotrophic factor
NUCB2 nucleobindin 2
OXTR oxytocin receptor
PDE4B phosphodiesterase 4B, cAMP-specific
PDIA4 protein disulfide isomerase family A, member 4
PDIA6 protein disulfide isomerase family A, member 6
PODXL podocalyxin-like
PTGES prostaglandin E synthase
RAD9A RAD9 homolog A (S. pombe)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS1 regulator of G-protein signaling 1
SCGB2A1 secretoglobin, family 2A, member 1
SDF2L1 stromal cell-derived factor 2-like 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SIK1 salt-inducible kinase 1
SLC35B1 solute carrier family 35, member B1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
TESC tescalcin
TSPAN13 tetraspanin 13
WBP5 WW domain binding protein 5

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
AEBP1 AE binding protein 1
ANXA1 annexin A1
BGN biglycan
CD24 CD24 molecule
CDKN2A cyclin-dependent kinase inhibitor 2A
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL6A3 collagen, type VI, alpha 3
COLEC12 collectin sub-family member 12
CRISP3 cysteine-rich secretory protein 3
CST1 cystatin SN
CYTL1 cytokine-like 1
DCT dopachrome tautomerase
EDNRB endothelin receptor type B
EVI2A ecotropic viral integration site 2A
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FRZB frizzled-related protein
GATA2 GATA binding protein 2
GPNMB glycoprotein (transmembrane) nmb
HES1 hes family bHLH transcription factor 1
HOXA10 homeobox A10
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IGLL1 immunoglobulin lambda-like polypeptide 1
INSIG1 insulin induced gene 1
KIAA1033 KIAA1033
KRT15 keratin 15, type I
LOXL2 lysyl oxidase-like 2
NFIB nuclear factor I/B
NRN1 neuritin 1
PCP4 Purkinje cell protein 4
PEG10 paternally expressed 10
QPCT glutaminyl-peptide cyclotransferase
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RPL37A ribosomal protein L37a
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SDC2 syndecan 2
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
TFPI2 tissue factor pathway inhibitor 2
THBS2 thrombospondin 2