BRD-A19500257_geldanamycin_BT20_3_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

89 genes differentially expressed following the BRD-A19500257_geldanamycin_BT20_3_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C3 aldo-keto reductase family 1, member C3
ASCL1 achaete-scute family bHLH transcription factor 1
BAG3 BCL2-associated athanogene 3
BCL2 B-cell CLL/lymphoma 2
CDK2AP2 cyclin-dependent kinase 2 associated protein 2
CRELD2 cysteine-rich with EGF-like domains 2
CSTA cystatin A (stefin A)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
FAM134B family with sequence similarity 134, member B
FKBP11 FK506 binding protein 11, 19 kDa
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV3-20 immunoglobulin kappa variable 3-20
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLV2-23 immunoglobulin lambda variable 2-23
IGLV3-19 immunoglobulin lambda variable 3-19
IRF8 interferon regulatory factor 8
IRS2 insulin receptor substrate 2
JCHAIN joining chain of multimeric IgA and IgM
JMJD6 jumonji domain containing 6
KDM5D lysine (K)-specific demethylase 5D
LOC100505650 uncharacterized LOC100505650
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MANF mesencephalic astrocyte-derived neurotrophic factor
MAOB monoamine oxidase B
MCL1 myeloid cell leukemia 1
MSMB microseminoprotein, beta-
P4HB prolyl 4-hydroxylase, beta polypeptide
PPIB peptidylprolyl isomerase B (cyclophilin B)
PPOX protoporphyrinogen oxidase
RGS2 regulator of G-protein signaling 2
RPS4Y1 ribosomal protein S4, Y-linked 1
TES testin LIM domain protein
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
XBP1 X-box binding protein 1

decreased expression

Symbol Name
ACAA2 acetyl-CoA acyltransferase 2
ADD3 adducin 3 (gamma)
ADGRG2 adhesion G protein-coupled receptor G2
ARL4C ADP-ribosylation factor-like 4C
ATP5I ATP synthase, H+ transporting, mitochondrial Fo complex, subunit E
BGN biglycan
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCND2 cyclin D2
CD9 CD9 molecule
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
CYR61 cysteine-rich, angiogenic inducer, 61
EMP1 epithelial membrane protein 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
GREM1 gremlin 1, DAN family BMP antagonist
HES1 hes family bHLH transcription factor 1
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT15 keratin 15, type I
LEF1 lymphoid enhancer-binding factor 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MATN2 matrilin 2
MMP9 matrix metallopeptidase 9
MXRA5 matrix-remodelling associated 5
NOV nephroblastoma overexpressed
PNPLA4 patatin-like phospholipase domain containing 4
POSTN periostin, osteoblast specific factor
PSD3 pleckstrin and Sec7 domain containing 3
PXDN peroxidasin
S100A11 S100 calcium binding protein A11
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SNAI2 snail family zinc finger 2
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TCL1A T-cell leukemia/lymphoma 1A
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMEM158 transmembrane protein 158 (gene/pseudogene)
VCAN versican
VPREB3 pre-B lymphocyte 3
XIST X inactive specific transcript (non-protein coding)