BRD-A19500257_geldanamycin_BT20_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

300 genes differentially expressed following the BRD-A19500257_geldanamycin_BT20_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ACBD3 acyl-CoA binding domain containing 3
ADGRG2 adhesion G protein-coupled receptor G2
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
AKAP8L A kinase (PRKA) anchor protein 8-like
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
AMPD3 adenosine monophosphate deaminase 3
ANO10 anoctamin 10
APOD apolipoprotein D
ARF4 ADP-ribosylation factor 4
ARL1 ADP-ribosylation factor-like 1
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ARMCX1 armadillo repeat containing, X-linked 1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BCHE butyrylcholinesterase
BUB3 BUB3 mitotic checkpoint protein
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
CALU calumenin
CANX calnexin
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCL20 chemokine (C-C motif) ligand 20
CD164 CD164 molecule, sialomucin
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLU clusterin
COL3A1 collagen, type III, alpha 1
COPA coatomer protein complex, subunit alpha
COPB1 coatomer protein complex, subunit beta 1
CPE carboxypeptidase E
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CREB3L2 cAMP responsive element binding protein 3-like 2
CRELD2 cysteine-rich with EGF-like domains 2
CRYAB crystallin, alpha B
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTR9 CTR9, Paf1/RNA polymerase II complex component
CTSL cathepsin L
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
ELANE elastase, neutrophil expressed
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FAM134B family with sequence similarity 134, member B
FAM20B family with sequence similarity 20, member B
FAM3C family with sequence similarity 3, member C
FAM46A family with sequence similarity 46, member A
FAM46C family with sequence similarity 46, member C
FKBP14 FK506 binding protein 14, 22 kDa
FTH1 ferritin, heavy polypeptide 1
GCLC glutamate-cysteine ligase, catalytic subunit
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLUL glutamate-ammonia ligase
GOLT1B golgi transport 1B
GORASP2 golgi reassembly stacking protein 2, 55kDa
GPC3 glypican 3
GPM6B glycoprotein M6B
GPNMB glycoprotein (transmembrane) nmb
HIPK1 homeodomain interacting protein kinase 1
HIST1H2AC histone cluster 1, H2ac
HLA-DRA major histocompatibility complex, class II, DR alpha
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HP haptoglobin
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
HYOU1 hypoxia up-regulated 1
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IGKV4-1 immunoglobulin kappa variable 4-1
IL7R interleukin 7 receptor
INPP1 inositol polyphosphate-1-phosphatase
IRX5 iroquois homeobox 5
ITM2C integral membrane protein 2C
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KDM3A lysine (K)-specific demethylase 3A
KIAA1033 KIAA1033
KLHDC10 kelch domain containing 10
LAPTM5 lysosomal protein transmembrane 5
MAGED1 melanoma antigen family D1
MAGED2 melanoma antigen family D2
MANF mesencephalic astrocyte-derived neurotrophic factor
MAP1A microtubule-associated protein 1A
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
MARCH8 membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
MBP myelin basic protein
MLPH melanophilin
MSMB microseminoprotein, beta-
NNMT nicotinamide N-methyltransferase
NPTX2 neuronal pentraxin II
NRIP3 nuclear receptor interacting protein 3
NUCB2 nucleobindin 2
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
P4HB prolyl 4-hydroxylase, beta polypeptide
PDE4B phosphodiesterase 4B, cAMP-specific
PDIA3 protein disulfide isomerase family A, member 3
PDIA4 protein disulfide isomerase family A, member 4
PDIA6 protein disulfide isomerase family A, member 6
PEG3 paternally expressed 3
PJA2 praja ring finger 2, E3 ubiquitin protein ligase
PLA1A phospholipase A1 member A
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PPIB peptidylprolyl isomerase B (cyclophilin B)
PRRC1 proline-rich coiled-coil 1
PSAT1 phosphoserine aminotransferase 1
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
QPRT quinolinate phosphoribosyltransferase
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
S100A4 S100 calcium binding protein A4
S100P S100 calcium binding protein P
SAP18 Sin3A-associated protein, 18kDa
SARAF store-operated calcium entry-associated regulatory factor
SC5D sterol-C5-desaturase
SEC13 SEC13 homolog (S. cerevisiae)
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SERINC3 serine incorporator 3
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SF3B1 splicing factor 3b, subunit 1, 155kDa
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SLC35B1 solute carrier family 35, member B1
SLPI secretory leukocyte peptidase inhibitor
SOD2 superoxide dismutase 2, mitochondrial
SRGN serglycin
SSR1 signal sequence receptor, alpha
STK17B serine/threonine kinase 17b
TARP TCR gamma alternate reading frame protein
TIMP3 TIMP metallopeptidase inhibitor 3
TMED3 transmembrane emp24 protein transport domain containing 3
TMEM45A transmembrane protein 45A
TMX4 thioredoxin-related transmembrane protein 4
TNS1 tensin 1
TOB1 transducer of ERBB2, 1
TRAC T cell receptor alpha constant
TRAK2 trafficking protein, kinesin binding 2
TSC22D3 TSC22 domain family, member 3
TSPAN13 tetraspanin 13
TXNIP thioredoxin interacting protein
UBE2H ubiquitin-conjugating enzyme E2H
UFM1 ubiquitin-fold modifier 1
UGCG UDP-glucose ceramide glucosyltransferase
UGDH UDP-glucose 6-dehydrogenase
VAV3 vav 3 guanine nucleotide exchange factor
WWP1 WW domain containing E3 ubiquitin protein ligase 1
ZC3H11A zinc finger CCCH-type containing 11A
ZNF652 zinc finger protein 652
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACD adrenocortical dysplasia homolog (mouse)
ACTN1 actinin, alpha 1
ADM adrenomedullin
AHR aryl hydrocarbon receptor
AK4 adenylate kinase 4
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA1 annexin A1
ANXA3 annexin A3
ATF3 activating transcription factor 3
BTG2 BTG family, member 2
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAPN1 calpain 1, (mu/I) large subunit
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDC45 cell division cycle 45
CDKN2A cyclin-dependent kinase inhibitor 2A
CECR5 cat eye syndrome chromosome region, candidate 5
CEP68 centrosomal protein 68kDa
CETN3 centrin, EF-hand protein, 3
COG4 component of oligomeric golgi complex 4
CTBP2 C-terminal binding protein 2
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CYR61 cysteine-rich, angiogenic inducer, 61
DERA deoxyribose-phosphate aldolase (putative)
DHFR dihydrofolate reductase
DKK3 dickkopf WNT signaling pathway inhibitor 3
DMD dystrophin
DUSP5 dual specificity phosphatase 5
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM216A family with sequence similarity 216, member A
FGR FGR proto-oncogene, Src family tyrosine kinase
FHL2 four and a half LIM domains 2
FLNA filamin A, alpha
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOXF2 forkhead box F2
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GAL galanin/GMAP prepropeptide
GALE UDP-galactose-4-epimerase
GATA3 GATA binding protein 3
GATA6 GATA binding protein 6
GCHFR GTP cyclohydrolase I feedback regulator
GFOD1 glucose-fructose oxidoreductase domain containing 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
GNG11 guanine nucleotide binding protein (G protein), gamma 11
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HN1 hematological and neurological expressed 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ITGA6 integrin, alpha 6
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
L1CAM L1 cell adhesion molecule
LGALS1 lectin, galactoside-binding, soluble, 1
LMNB1 lamin B1
MACF1 microtubule-actin crosslinking factor 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCKSL1 MARCKS-like 1
MCM5 minichromosome maintenance complex component 5
MET MET proto-oncogene, receptor tyrosine kinase
MSH6 mutS homolog 6
MTERF3 mitochondrial transcription termination factor 3
MTMR11 myotubularin related protein 11
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYOF myoferlin
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein
NFIB nuclear factor I/B
NID1 nidogen 1
NPDC1 neural proliferation, differentiation and control, 1
NRIP1 nuclear receptor interacting protein 1
OIP5 Opa interacting protein 5
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PFKP phosphofructokinase, platelet
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAU plasminogen activator, urokinase
PLBD1 phospholipase B domain containing 1
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLEKHJ1 pleckstrin homology domain containing, family J member 1
PLS3 plastin 3
PNMA1 paraneoplastic Ma antigen 1
PNP purine nucleoside phosphorylase
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PXMP2 peroxisomal membrane protein 2, 22kDa
RAB31 RAB31, member RAS oncogene family
RAD51 RAD51 recombinase
RANBP1 RAN binding protein 1
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBPMS RNA binding protein with multiple splicing
RELN reelin
RFTN1 raftlin, lipid raft linker 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP4 secreted frizzled-related protein 4
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLC38A1 solute carrier family 38, member 1
SULF1 sulfatase 1
TAGLN transgelin
TAGLN2 transgelin 2
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFPI2 tissue factor pathway inhibitor 2
THBS1 thrombospondin 1
TK1 thymidine kinase 1, soluble
TM4SF1 transmembrane 4 L six family member 1
TMSB15A thymosin beta 15a
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNS3 tensin 3
TOX3 TOX high mobility group box family member 3
TP53I3 tumor protein p53 inducible protein 3
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
TSPAN4 tetraspanin 4
TUBB6 tubulin, beta 6 class V
UPP1 uridine phosphorylase 1
VCAN versican
VIM vimentin
ZFPM2 zinc finger protein, FOG family member 2