BRD-A19500257_geldanamycin_BT20_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

238 genes differentially expressed following the BRD-A19500257_geldanamycin_BT20_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AFF1 AF4/FMR2 family, member 1
APMAP adipocyte plasma membrane associated protein
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
AUTS2 autism susceptibility candidate 2
B3GNT1
BAG3 BCL2-associated athanogene 3
BMI1 BMI1 proto-oncogene, polycomb ring finger
C1QB complement component 1, q subcomponent, B chain
CA11 carbonic anhydrase XI
CALCOCO2 calcium binding and coiled-coil domain 2
CALU calumenin
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family)
CCDC28A coiled-coil domain containing 28A
CCL20 chemokine (C-C motif) ligand 20
CDK19 cyclin-dependent kinase 19
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COL1A2 collagen, type I, alpha 2
COL2A1 collagen, type II, alpha 1
COL3A1 collagen, type III, alpha 1
CPD carboxypeptidase D
CPE carboxypeptidase E
CPVL carboxypeptidase, vitellogenic-like
CREB3L2 cAMP responsive element binding protein 3-like 2
CRYAB crystallin, alpha B
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL9 chemokine (C-X-C motif) ligand 9
DEPTOR DEP domain containing MTOR-interacting protein
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DPT dermatopontin
ENO2 enolase 2 (gamma, neuronal)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
FAM117A family with sequence similarity 117, member A
FAM134B family with sequence similarity 134, member B
FHL1 four and a half LIM domains 1
FMOD fibromodulin
FXR1 fragile X mental retardation, autosomal homolog 1
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GLUL glutamate-ammonia ligase
GPC3 glypican 3
GPNMB glycoprotein (transmembrane) nmb
GPR88 G protein-coupled receptor 88
GSTA1 glutathione S-transferase alpha 1
HLA-DMB major histocompatibility complex, class II, DM beta
HP haptoglobin
HS2ST1 heparan sulfate 2-O-sulfotransferase 1
HSPA1A heat shock 70kDa protein 1A
HSPA4L heat shock 70kDa protein 4-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPE1 heat shock 10kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
IDO1 indoleamine 2,3-dioxygenase 1
IRX5 iroquois homeobox 5
JMJD6 jumonji domain containing 6
KLHDC10 kelch domain containing 10
LOX lysyl oxidase
MAOA monoamine oxidase A
MEF2C myocyte enhancer factor 2C
MFAP3L microfibrillar-associated protein 3-like
MFAP5 microfibrillar associated protein 5
MOXD1 monooxygenase, DBH-like 1
MSMB microseminoprotein, beta-
MXRA7 matrix-remodelling associated 7
NFE2L1 nuclear factor, erythroid 2-like 1
NPTX2 neuronal pentraxin II
NRN1 neuritin 1
NUCB2 nucleobindin 2
NUSAP1 nucleolar and spindle associated protein 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCDH9 protocadherin 9
PJA2 praja ring finger 2, E3 ubiquitin protein ligase
PLIN2 perilipin 2
PLK1 polo-like kinase 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PRKCB protein kinase C, beta
PRUNE2 prune homolog 2 (Drosophila)
PTN pleiotrophin
PTPRC protein tyrosine phosphatase, receptor type, C
QPRT quinolinate phosphoribosyltransferase
RAB11FIP2 RAB11 family interacting protein 2 (class I)
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
REEP1 receptor accessory protein 1
RGS2 regulator of G-protein signaling 2
RNASE6 ribonuclease, RNase A family, k6
SAT1 spermidine/spermine N1-acetyltransferase 1
SCARB2 scavenger receptor class B, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SEPP1 selenoprotein P, plasma, 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SPATS2 spermatogenesis associated, serine-rich 2
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SRGN serglycin
STC2 stanniocalcin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TOB1 transducer of ERBB2, 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TSC22D3 TSC22 domain family, member 3
TSKU tsukushi, small leucine rich proteoglycan
TSPAN13 tetraspanin 13
TWF1 twinfilin actin binding protein 1
TXNIP thioredoxin interacting protein
UBE2C ubiquitin-conjugating enzyme E2C
UBXN7 UBX domain protein 7
UPK1B uroplakin 1B
VAV3 vav 3 guanine nucleotide exchange factor
WASL Wiskott-Aldrich syndrome-like
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABLIM1 actin binding LIM protein 1
ACD adrenocortical dysplasia homolog (mouse)
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA3 annexin A3
AREG amphiregulin
ATF3 activating transcription factor 3
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
BRCA1 breast cancer 1, early onset
BST2 bone marrow stromal cell antigen 2
BTG2 BTG family, member 2
C1ORF106 chromosome 1 open reading frame 106
CALML5 calmodulin-like 5
CBR3 carbonyl reductase 3
CD24 CD24 molecule
CD9 CD9 molecule
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDK4 cyclin-dependent kinase 4
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHGB chromogranin B
COL10A1 collagen, type X, alpha 1
CSTA cystatin A (stefin A)
DHFR dihydrofolate reductase
EIF5 eukaryotic translation initiation factor 5
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
EREG epiregulin
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GALE UDP-galactose-4-epimerase
GFOD1 glucose-fructose oxidoreductase domain containing 1
GGCT gamma-glutamylcyclotransferase
GNAS GNAS complex locus
GOLGA8A golgin A8 family, member A
GPX2 glutathione peroxidase 2
GREM1 gremlin 1, DAN family BMP antagonist
HMOX1 heme oxygenase 1
HN1 hematological and neurological expressed 1
HOPX HOP homeobox
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
IFRD2 interferon-related developmental regulator 2
IGFBP5 insulin-like growth factor binding protein 5
INA internexin neuronal intermediate filament protein, alpha
INHBA inhibin, beta A
ITGB5 integrin, beta 5
JAG1 jagged 1
JUN jun proto-oncogene
JUNB jun B proto-oncogene
L1CAM L1 cell adhesion molecule
LHFP lipoma HMGIC fusion partner
LIF leukemia inhibitory factor
LIMCH1 LIM and calponin homology domains 1
LMCD1 LIM and cysteine-rich domains 1
LSR lipolysis stimulated lipoprotein receptor
MAPK13 mitogen-activated protein kinase 13
MARCKSL1 MARCKS-like 1
MCM3 minichromosome maintenance complex component 3
MFSD10 major facilitator superfamily domain containing 10
MMP11 matrix metallopeptidase 11
MMP3 matrix metallopeptidase 3
MPHOSPH6 M-phase phosphoprotein 6
MUC1 mucin 1, cell surface associated
NBEAL2 neurobeachin-like 2
NFIB nuclear factor I/B
NID1 nidogen 1
NQO1 NAD(P)H dehydrogenase, quinone 1
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR2F6 nuclear receptor subfamily 2, group F, member 6
NRIP1 nuclear receptor interacting protein 1
PAQR4 progestin and adipoQ receptor family member IV
PCNA proliferating cell nuclear antigen
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLEKHJ1 pleckstrin homology domain containing, family J member 1
PLGRKT plasminogen receptor, C-terminal lysine transmembrane protein
PNP purine nucleoside phosphorylase
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRKCD protein kinase C, delta
RAD51 RAD51 recombinase
RANBP1 RAN binding protein 1
RBPMS RNA binding protein with multiple splicing
RIN2 Ras and Rab interactor 2
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFN stratifin
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SPRED2 sprouty-related, EVH1 domain containing 2
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TFPI2 tissue factor pathway inhibitor 2
THBS1 thrombospondin 1
TKTL1 transketolase-like 1
TM4SF1 transmembrane 4 L six family member 1
TMOD1 tropomodulin 1
TP53I3 tumor protein p53 inducible protein 3
TPM1 tropomyosin 1 (alpha)
UPP1 uridine phosphorylase 1
VCAN versican
VSNL1 visinin-like 1
WNT5A wingless-type MMTV integration site family, member 5A