BRD-A19500257_geldanamycin_BT20_24_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

277 genes differentially expressed following the BRD-A19500257_geldanamycin_BT20_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL1 acyl-CoA synthetase long-chain family member 1
AFF1 AF4/FMR2 family, member 1
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
ALOX5AP arachidonate 5-lipoxygenase-activating protein
APOD apolipoprotein D
ARL1 ADP-ribosylation factor-like 1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
AUTS2 autism susceptibility candidate 2
BAG3 BCL2-associated athanogene 3
BCHE butyrylcholinesterase
BEX1 brain expressed, X-linked 1
BLMH bleomycin hydrolase
BPGM 2,3-bisphosphoglycerate mutase
CA12 carbonic anhydrase XII
CALU calumenin
CCDC28A coiled-coil domain containing 28A
CCL20 chemokine (C-C motif) ligand 20
CD163 CD163 molecule
CD164 CD164 molecule, sialomucin
CDK19 cyclin-dependent kinase 19
CHI3L2 chitinase 3-like 2
CHPT1 choline phosphotransferase 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COL1A2 collagen, type I, alpha 2
COL2A1 collagen, type II, alpha 1
COL3A1 collagen, type III, alpha 1
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CPD carboxypeptidase D
CRYAB crystallin, alpha B
CXCL5 chemokine (C-X-C motif) ligand 5
DCN decorin
DEFB1 defensin, beta 1
DLK1 delta-like 1 homolog (Drosophila)
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EIF4B eukaryotic translation initiation factor 4B
ELOVL5 ELOVL fatty acid elongase 5
ENO2 enolase 2 (gamma, neuronal)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FKBP10 FK506 binding protein 10, 65 kDa
FOXJ3 forkhead box J3
FXR1 fragile X mental retardation, autosomal homolog 1
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GHITM growth hormone inducible transmembrane protein
GLIPR1 GLI pathogenesis-related 1
GLUL glutamate-ammonia ligase
GOLT1B golgi transport 1B
GPATCH8 G patch domain containing 8
GPC3 glypican 3
GPNMB glycoprotein (transmembrane) nmb
GPR88 G protein-coupled receptor 88
GPX3 glutathione peroxidase 3
HBB hemoglobin, beta
HBD hemoglobin, delta
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HP haptoglobin
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA4L heat shock 70kDa protein 4-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB8 heat shock 22kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IFITM1 interferon induced transmembrane protein 1
JAM3 junctional adhesion molecule 3
JMJD6 jumonji domain containing 6
KDM3A lysine (K)-specific demethylase 3A
KDM5A lysine (K)-specific demethylase 5A
KLHDC10 kelch domain containing 10
LAPTM5 lysosomal protein transmembrane 5
LGALS8 lectin, galactoside-binding, soluble, 8
LOX lysyl oxidase
LTF lactotransferrin
MAGED1 melanoma antigen family D1
MAOA monoamine oxidase A
MAP1A microtubule-associated protein 1A
MBP myelin basic protein
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MFAP5 microfibrillar associated protein 5
MIA melanoma inhibitory activity
MICB MHC class I polypeptide-related sequence B
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MLPH melanophilin
MOXD1 monooxygenase, DBH-like 1
MSMB microseminoprotein, beta-
NPC2 Niemann-Pick disease, type C2
NPTX2 neuronal pentraxin II
NRIP3 nuclear receptor interacting protein 3
NUPR1 nuclear protein, transcriptional regulator, 1
OXTR oxytocin receptor
PDE4D phosphodiesterase 4D, cAMP-specific
PLA1A phospholipase A1 member A
PLIN2 perilipin 2
PLK1 polo-like kinase 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PNMAL1 paraneoplastic Ma antigen family-like 1
PRR15L proline rich 15-like
PRUNE2 prune homolog 2 (Drosophila)
PTN pleiotrophin
PTX3 pentraxin 3, long
QPRT quinolinate phosphoribosyltransferase
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RGS2 regulator of G-protein signaling 2
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RORA RAR-related orphan receptor A
RPL22 ribosomal protein L22
RPL31 ribosomal protein L31
RPS4Y1 ribosomal protein S4, Y-linked 1
RYBP RING1 and YY1 binding protein
S100A8 S100 calcium binding protein A8
SECISBP2L SECIS binding protein 2-like
SEPP1 selenoprotein P, plasma, 1
SERP1 stress-associated endoplasmic reticulum protein 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group)
SOD2 superoxide dismutase 2, mitochondrial
SPINK1 serine peptidase inhibitor, Kazal type 1
SRGN serglycin
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TMED9 transmembrane emp24 protein transport domain containing 9
TMEM45A transmembrane protein 45A
TMEM9B TMEM9 domain family, member B
TREM1 triggering receptor expressed on myeloid cells 1
TSPAN13 tetraspanin 13
TXNIP thioredoxin interacting protein
UGCG UDP-glucose ceramide glucosyltransferase
WASF3 WAS protein family, member 3
YME1L1 YME1-like 1 ATPase
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABLIM1 actin binding LIM protein 1
ACD adrenocortical dysplasia homolog (mouse)
ACOT9 acyl-CoA thioesterase 9
ADIRF adipogenesis regulatory factor
AK4 adenylate kinase 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALOX5 arachidonate 5-lipoxygenase
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA1 annexin A1
ANXA3 annexin A3
ANXA4 annexin A4
AREG amphiregulin
ATF3 activating transcription factor 3
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
C1ORF106 chromosome 1 open reading frame 106
CAB39 calcium binding protein 39
CALML5 calmodulin-like 5
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAPN1 calpain 1, (mu/I) large subunit
CARD10 caspase recruitment domain family, member 10
CAV2 caveolin 2
CBR3 carbonyl reductase 3
CD24 CD24 molecule
CD44 CD44 molecule (Indian blood group)
CDC45 cell division cycle 45
CHRDL1 chordin-like 1
CLC Charcot-Leyden crystal galectin
CNIH4 cornichon family AMPA receptor auxiliary protein 4
CTTN cortactin
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DDB2 damage-specific DNA binding protein 2, 48kDa
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DGKA diacylglycerol kinase, alpha 80kDa
DHFR dihydrofolate reductase
DKK3 dickkopf WNT signaling pathway inhibitor 3
DMD dystrophin
DUOX2 dual oxidase 2
DUSP3 dual specificity phosphatase 3
EIF5 eukaryotic translation initiation factor 5
F3 coagulation factor III (thromboplastin, tissue factor)
FERMT1 fermitin family member 1
FGFBP1 fibroblast growth factor binding protein 1
FLNA filamin A, alpha
FLNB filamin B, beta
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GALE UDP-galactose-4-epimerase
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
GATA3 GATA binding protein 3
GFOD1 glucose-fructose oxidoreductase domain containing 1
GRIA2 glutamate receptor, ionotropic, AMPA 2
HIST1H2BG histone cluster 1, H2bg
HMOX1 heme oxygenase 1
HN1 hematological and neurological expressed 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IFRD2 interferon-related developmental regulator 2
IL17RB interleukin 17 receptor B
INHBA inhibin, beta A
ITGA6 integrin, alpha 6
ITGB4 integrin, beta 4
JAG1 jagged 1
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KYNU kynureninase
LGALS3 lectin, galactoside-binding, soluble, 3
LIMCH1 LIM and calponin homology domains 1
LMCD1 LIM and cysteine-rich domains 1
LMNA lamin A/C
LMO3 LIM domain only 3 (rhombotin-like 2)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCKSL1 MARCKS-like 1
MBNL2 muscleblind-like splicing regulator 2
MCM3 minichromosome maintenance complex component 3
MFSD10 major facilitator superfamily domain containing 10
MMP3 matrix metallopeptidase 3
MPZL2 myelin protein zero-like 2
MRPS16 mitochondrial ribosomal protein S16
MSH6 mutS homolog 6
MUC1 mucin 1, cell surface associated
NAE1 NEDD8 activating enzyme E1 subunit 1
NID1 nidogen 1
NPDC1 neural proliferation, differentiation and control, 1
OLFM4 olfactomedin 4
PALLD palladin, cytoskeletal associated protein
PAQR4 progestin and adipoQ receptor family member IV
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PFKP phosphofructokinase, platelet
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PHYH phytanoyl-CoA 2-hydroxylase
PLAU plasminogen activator, urokinase
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
PNMA1 paraneoplastic Ma antigen 1
PNP purine nucleoside phosphorylase
PRKCD protein kinase C, delta
RBM34 RNA binding motif protein 34
RBPMS RNA binding protein with multiple splicing
RPL37A ribosomal protein L37a
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
SCAND1 SCAN domain containing 1
SDC1 syndecan 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SETD6 SET domain containing 6
SFN stratifin
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLC38A1 solute carrier family 38, member 1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SNAI2 snail family zinc finger 2
SRSF6 serine/arginine-rich splicing factor 6
SRSF7 serine/arginine-rich splicing factor 7
STEAP3 STEAP family member 3, metalloreductase
TAGLN2 transgelin 2
TFPI2 tissue factor pathway inhibitor 2
THBS1 thrombospondin 1
TM4SF1 transmembrane 4 L six family member 1
TMEM176B transmembrane protein 176B
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TPM1 tropomyosin 1 (alpha)
TRIB3 tribbles pseudokinase 3
VCAN versican
WNT5A wingless-type MMTV integration site family, member 5A
XIST X inactive specific transcript (non-protein coding)
ZFP36L1 ZFP36 ring finger protein-like 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZFPM2 zinc finger protein, FOG family member 2