BRD-A19500257_geldanamycin_BT20_24_h_0.12_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

251 genes differentially expressed following the BRD-A19500257_geldanamycin_BT20_24_h_0.12_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
AFF1 AF4/FMR2 family, member 1
AHNAK2 AHNAK nucleoprotein 2
ANO10 anoctamin 10
APOD apolipoprotein D
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
AQP1 aquaporin 1 (Colton blood group)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BASP1 brain abundant, membrane attached signal protein 1
BIRC3 baculoviral IAP repeat containing 3
C1ORF54 chromosome 1 open reading frame 54
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
CCDC28A coiled-coil domain containing 28A
CCL20 chemokine (C-C motif) ligand 20
CCND2 cyclin D2
CD93 CD93 molecule
CGA glycoprotein hormones, alpha polypeptide
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL15A1 collagen, type XV, alpha 1
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CPE carboxypeptidase E
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DCN decorin
DENND1B DENN/MADD domain containing 1B
DHX40 DEAH (Asp-Glu-Ala-His) box polypeptide 40
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
ELOVL2 ELOVL fatty acid elongase 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
F13A1 coagulation factor XIII, A1 polypeptide
FABP6 fatty acid binding protein 6, ileal
FAM20B family with sequence similarity 20, member B
FOXJ3 forkhead box J3
FYN FYN proto-oncogene, Src family tyrosine kinase
GDF15 growth differentiation factor 15
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
GPM6B glycoprotein M6B
GPNMB glycoprotein (transmembrane) nmb
GPX3 glutathione peroxidase 3
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA4L heat shock 70kDa protein 4-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IFITM1 interferon induced transmembrane protein 1
IFRD1 interferon-related developmental regulator 1
ITM2C integral membrane protein 2C
JMJD6 jumonji domain containing 6
KDM3A lysine (K)-specific demethylase 3A
KIAA0232 KIAA0232
KLHDC10 kelch domain containing 10
KLK11 kallikrein-related peptidase 11
LAPTM5 lysosomal protein transmembrane 5
LRP12 low density lipoprotein receptor-related protein 12
LTBP1 latent transforming growth factor beta binding protein 1
LUM lumican
MAOA monoamine oxidase A
MAP1A microtubule-associated protein 1A
MFAP5 microfibrillar associated protein 5
MOXD1 monooxygenase, DBH-like 1
MSMB microseminoprotein, beta-
MYO1B myosin IB
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NPTX2 neuronal pentraxin II
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRIP3 nuclear receptor interacting protein 3
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9
ODC1 ornithine decarboxylase 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PAMR1 peptidase domain containing associated with muscle regeneration 1
PCYOX1 prenylcysteine oxidase 1
PER2 period circadian clock 2
PLAGL1 pleiomorphic adenoma gene-like 1
PLTP phospholipid transfer protein
PNMAL1 paraneoplastic Ma antigen family-like 1
POSTN periostin, osteoblast specific factor
PPAP2B phosphatidic acid phosphatase type 2B
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PTX3 pentraxin 3, long
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RCN3 reticulocalbin 3, EF-hand calcium binding domain
RGCC regulator of cell cycle
SATB1 SATB homeobox 1
SCGB2A2 secretoglobin, family 2A, member 2
SCUBE2 signal peptide, CUB domain, EGF-like 2
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
SEC24B SEC24 family member B
SEPP1 selenoprotein P, plasma, 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SIK1 salt-inducible kinase 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLIT2 slit homolog 2 (Drosophila)
SOD2 superoxide dismutase 2, mitochondrial
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPTBN1 spectrin, beta, non-erythrocytic 1
SRGN serglycin
STC2 stanniocalcin 2
STK17B serine/threonine kinase 17b
STOM stomatin
SYNM synemin, intermediate filament protein
TARP TCR gamma alternate reading frame protein
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM45A transmembrane protein 45A
TNS1 tensin 1
TOB1 transducer of ERBB2, 1
TSPAN13 tetraspanin 13
TSPYL5 TSPY-like 5
TXNIP thioredoxin interacting protein
UBFD1 ubiquitin family domain containing 1
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
XIST X inactive specific transcript (non-protein coding)
ZNF331 zinc finger protein 331
ZNF652 zinc finger protein 652

decreased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
ACD adrenocortical dysplasia homolog (mouse)
AKAP12 A kinase (PRKA) anchor protein 12
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
AMDHD2 amidohydrolase domain containing 2
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA1 annexin A1
ANXA5 annexin A5
ASPH aspartate beta-hydroxylase
ATHL1 ATH1, acid trehalase-like 1 (yeast)
BST2 bone marrow stromal cell antigen 2
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAPN1 calpain 1, (mu/I) large subunit
CAPN2 calpain 2, (m/II) large subunit
CCNE2 cyclin E2
CD24 CD24 molecule
CD44 CD44 molecule (Indian blood group)
CDC20 cell division cycle 20
CDC45 cell division cycle 45
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDK4 cyclin-dependent kinase 4
CDKN2A cyclin-dependent kinase inhibitor 2A
CFI complement factor I
CLTB clathrin, light chain B
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family)
CYB5A cytochrome b5 type A (microsomal)
CYR61 cysteine-rich, angiogenic inducer, 61
DHFR dihydrofolate reductase
EGFR epidermal growth factor receptor
ELOVL1 ELOVL fatty acid elongase 1
F3 coagulation factor III (thromboplastin, tissue factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FKBP11 FK506 binding protein 11, 19 kDa
FMO1 flavin containing monooxygenase 1
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
FXYD5 FXYD domain containing ion transport regulator 5
GALE UDP-galactose-4-epimerase
GATA6 GATA binding protein 6
GBP1 guanylate binding protein 1, interferon-inducible
GSTA4 glutathione S-transferase alpha 4
HOPX HOP homeobox
IER2 immediate early response 2
IER3 immediate early response 3
IFI16 interferon, gamma-inducible protein 16
IGFBP6 insulin-like growth factor binding protein 6
IL17RB interleukin 17 receptor B
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
KRT18 keratin 18, type I
KRT6B keratin 6B, type II
KYNU kynureninase
LAPTM4B lysosomal protein transmembrane 4 beta
LIMCH1 LIM and calponin homology domains 1
LOC100505650 uncharacterized LOC100505650
LSR lipolysis stimulated lipoprotein receptor
MARCKSL1 MARCKS-like 1
MBNL2 muscleblind-like splicing regulator 2
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MFSD10 major facilitator superfamily domain containing 10
MMP7 matrix metallopeptidase 7
MSN moesin
MTA1 metastasis associated 1
MTSS1 metastasis suppressor 1
MYOF myoferlin
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NPY1R neuropeptide Y receptor Y1
NQO1 NAD(P)H dehydrogenase, quinone 1
NRIP1 nuclear receptor interacting protein 1
PAQR4 progestin and adipoQ receptor family member IV
PCNA proliferating cell nuclear antigen
PFKP phosphofructokinase, platelet
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAU plasminogen activator, urokinase
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLK2 polo-like kinase 2
PLN phospholamban
PLS3 plastin 3
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPAP2C phosphatidic acid phosphatase type 2C
PRKCD protein kinase C, delta
PSIP1 PC4 and SFRS1 interacting protein 1
PSPH phosphoserine phosphatase
PTPRD protein tyrosine phosphatase, receptor type, D
RAI14 retinoic acid induced 14
RBM34 RNA binding motif protein 34
RBP1 retinol binding protein 1, cellular
RBPMS RNA binding protein with multiple splicing
RIN2 Ras and Rab interactor 2
S100A11 S100 calcium binding protein A11
S100A12 S100 calcium binding protein A12
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
SCAND1 SCAN domain containing 1
SDC1 syndecan 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFN stratifin
SPP1 secreted phosphoprotein 1
SRSF6 serine/arginine-rich splicing factor 6
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TFPI2 tissue factor pathway inhibitor 2
THAP11 THAP domain containing 11
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TK1 thymidine kinase 1, soluble
TM4SF1 transmembrane 4 L six family member 1
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TP53I3 tumor protein p53 inducible protein 3
TPM1 tropomyosin 1 (alpha)
VCAN versican
VIM vimentin
WNT5A wingless-type MMTV integration site family, member 5A
WSB2 WD repeat and SOCS box containing 2
ZFP36L1 ZFP36 ring finger protein-like 1
ZFPM2 zinc finger protein, FOG family member 2