BRD-A19500257_geldanamycin_BT20_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

251 genes differentially expressed following the BRD-A19500257_geldanamycin_BT20_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACKR3 atypical chemokine receptor 3
ACSL1 acyl-CoA synthetase long-chain family member 1
AFF1 AF4/FMR2 family, member 1
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
ALCAM activated leukocyte cell adhesion molecule
APOD apolipoprotein D
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)
ARMCX1 armadillo repeat containing, X-linked 1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
B3GNT1
BAG3 BCL2-associated athanogene 3
BAX BCL2-associated X protein
BHMT2 betaine--homocysteine S-methyltransferase 2
BPGM 2,3-bisphosphoglycerate mutase
C1ORF54 chromosome 1 open reading frame 54
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
CA12 carbonic anhydrase XII
CALU calumenin
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCDC28A coiled-coil domain containing 28A
CD1A CD1a molecule
CDK19 cyclin-dependent kinase 19
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL6A3 collagen, type VI, alpha 3
COPA coatomer protein complex, subunit alpha
CPE carboxypeptidase E
CRYAB crystallin, alpha B
CTR9 CTR9, Paf1/RNA polymerase II complex component
CTSK cathepsin K
CXCL13 chemokine (C-X-C motif) ligand 13
DCN decorin
DEFB1 defensin, beta 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
ENO2 enolase 2 (gamma, neuronal)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FXR1 fragile X mental retardation, autosomal homolog 1
FYN FYN proto-oncogene, Src family tyrosine kinase
GABARAPL1 GABA(A) receptor-associated protein like 1
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GLUL glutamate-ammonia ligase
GPNMB glycoprotein (transmembrane) nmb
HIST1H2BK histone cluster 1, H2bk
HMGB2 high mobility group box 2
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB8 heat shock 22kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPE1 heat shock 10kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
INPP1 inositol polyphosphate-1-phosphatase
INSR insulin receptor
ISLR immunoglobulin superfamily containing leucine-rich repeat
JAK1 Janus kinase 1
JMJD6 jumonji domain containing 6
KDM3A lysine (K)-specific demethylase 3A
KIF3B kinesin family member 3B
KLHDC10 kelch domain containing 10
KRT19 keratin 19, type I
LAMB1 laminin, beta 1
LRP12 low density lipoprotein receptor-related protein 12
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LY96 lymphocyte antigen 96
MAGED2 melanoma antigen family D2
MAOA monoamine oxidase A
MARCH8 membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
MB myoglobin
MEIS2 Meis homeobox 2
MFAP5 microfibrillar associated protein 5
MME membrane metallo-endopeptidase
MOXD1 monooxygenase, DBH-like 1
MSMB microseminoprotein, beta-
NEFL neurofilament, light polypeptide
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NPTX2 neuronal pentraxin II
OLFML3 olfactomedin-like 3
OXTR oxytocin receptor
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PCDH9 protocadherin 9
PEG3 paternally expressed 3
PIP prolactin-induced protein
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2
POPDC3 popeye domain containing 3
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTN pleiotrophin
PTX3 pentraxin 3, long
RANBP2 RAN binding protein 2
RIOK3 RIO kinase 3
RND3 Rho family GTPase 3
SCG2 secretogranin II
SCYL2 SCY1-like 2 (S. cerevisiae)
SF3B1 splicing factor 3b, subunit 1, 155kDa
SGK1 serum/glucocorticoid regulated kinase 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5)
SNX3 sorting nexin 3
SOD2 superoxide dismutase 2, mitochondrial
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
STK17B serine/threonine kinase 17b
STOM stomatin
TARP TCR gamma alternate reading frame protein
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM45A transmembrane protein 45A
TMEM47 transmembrane protein 47
TPBG trophoblast glycoprotein
TSC22D3 TSC22 domain family, member 3
TWF1 twinfilin actin binding protein 1
TWIST1 twist family bHLH transcription factor 1
TXNIP thioredoxin interacting protein
UPK1B uroplakin 1B
ZC3H11A zinc finger CCCH-type containing 11A
ZNF304 zinc finger protein 304
ZNF331 zinc finger protein 331
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
ACD adrenocortical dysplasia homolog (mouse)
ADRB2 adrenoceptor beta 2, surface
AMDHD2 amidohydrolase domain containing 2
ANKRD10 ankyrin repeat domain 10
ANXA3 annexin A3
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ATP11B ATPase, class VI, type 11B
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
CAB39 calcium binding protein 39
CALML5 calmodulin-like 5
CAPN1 calpain 1, (mu/I) large subunit
CCNE2 cyclin E2
CD24 CD24 molecule
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDK4 cyclin-dependent kinase 4
CDKN2A cyclin-dependent kinase inhibitor 2A
CLIC3 chloride intracellular channel 3
CRIP2 cysteine-rich protein 2
CRLF1 cytokine receptor-like factor 1
CSRP1 cysteine and glycine-rich protein 1
CYR61 cysteine-rich, angiogenic inducer, 61
DACT1 dishevelled-binding antagonist of beta-catenin 1
DERA deoxyribose-phosphate aldolase (putative)
DHFR dihydrofolate reductase
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLX2 distal-less homeobox 2
DMD dystrophin
EIF5 eukaryotic translation initiation factor 5
EREG epiregulin
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FGFBP1 fibroblast growth factor binding protein 1
FKBP11 FK506 binding protein 11, 19 kDa
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GFOD1 glucose-fructose oxidoreductase domain containing 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
GRIA2 glutamate receptor, ionotropic, AMPA 2
GSTA4 glutathione S-transferase alpha 4
HLF hepatic leukemia factor
HN1 hematological and neurological expressed 1
HOPX HOP homeobox
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IGFBP5 insulin-like growth factor binding protein 5
IL17RB interleukin 17 receptor B
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ITGA6 integrin, alpha 6
JAG1 jagged 1
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KIAA0485 uncharacterized LOC57235
KIF20A kinesin family member 20A
KLF6 Kruppel-like factor 6
KRT6B keratin 6B, type II
LGALS3 lectin, galactoside-binding, soluble, 3
LIMCH1 LIM and calponin homology domains 1
LMCD1 LIM and cysteine-rich domains 1
LMNA lamin A/C
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
MACF1 microtubule-actin crosslinking factor 1
MARCKSL1 MARCKS-like 1
MCM3 minichromosome maintenance complex component 3
MPZL2 myelin protein zero-like 2
MSH6 mutS homolog 6
NFIB nuclear factor I/B
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NR2F1 nuclear receptor subfamily 2, group F, member 1
PALMD palmdelphin
PAQR4 progestin and adipoQ receptor family member IV
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHYH phytanoyl-CoA 2-hydroxylase
PITX1 paired-like homeodomain 1
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLN phospholamban
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRKCD protein kinase C, delta
PRSS2 protease, serine, 2 (trypsin 2)
PRSS3 protease, serine, 3
RBPMS RNA binding protein with multiple splicing
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
RPS4Y1 ribosomal protein S4, Y-linked 1
RRAS2 related RAS viral (r-ras) oncogene homolog 2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCN3A sodium channel, voltage gated, type III alpha subunit
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SET SET nuclear proto-oncogene
SFN stratifin
SFRP4 secreted frizzled-related protein 4
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SPP1 secreted phosphoprotein 1
SPRY2 sprouty homolog 2 (Drosophila)
SRSF7 serine/arginine-rich splicing factor 7
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TACSTD2 tumor-associated calcium signal transducer 2
TAGLN2 transgelin 2
TKTL1 transketolase-like 1
TM4SF1 transmembrane 4 L six family member 1
TPM1 tropomyosin 1 (alpha)
TRIB3 tribbles pseudokinase 3
TYRP1 tyrosinase-related protein 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZFPM2 zinc finger protein, FOG family member 2