BRD-A19500257_geldanamycin_A673_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

135 genes differentially expressed following the BRD-A19500257_geldanamycin_A673_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATF5 activating transcription factor 5
AZU1 azurocidin 1
BAG3 BCL2-associated athanogene 3
BASP1 brain abundant, membrane attached signal protein 1
CALR calreticulin
CANX calnexin
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLIC4 chloride intracellular channel 4
CRELD2 cysteine-rich with EGF-like domains 2
CTH cystathionine gamma-lyase
CXCL13 chemokine (C-X-C motif) ligand 13
DCLK1 doublecortin-like kinase 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
ELANE elastase, neutrophil expressed
EPB41L3 erythrocyte membrane protein band 4.1-like 3
EZR ezrin
FAM129A family with sequence similarity 129, member A
FAM46A family with sequence similarity 46, member A
GAREM GRB2 associated, regulator of MAPK1
GOT1 glutamic-oxaloacetic transaminase 1, soluble
GSTA1 glutathione S-transferase alpha 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
HYOU1 hypoxia up-regulated 1
IGHD immunoglobulin heavy constant delta
IGL immunoglobulin lambda locus
INHBE inhibin, beta E
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
LCK LCK proto-oncogene, Src family tyrosine kinase
LMAN1 lectin, mannose-binding, 1
LUM lumican
MAP7 microtubule-associated protein 7
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MBNL2 muscleblind-like splicing regulator 2
MFSD10 major facilitator superfamily domain containing 10
MXRA5 matrix-remodelling associated 5
MYOF myoferlin
NRIP1 nuclear receptor interacting protein 1
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDE4D phosphodiesterase 4D, cAMP-specific
PDGFD platelet derived growth factor D
PDIA3 protein disulfide isomerase family A, member 3
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PON3 paraoxonase 3
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAT1 phosphoserine aminotransferase 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RBKS ribokinase
RCAN1 regulator of calcineurin 1
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SDF2L1 stromal cell-derived factor 2-like 1
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SORBS2 sorbin and SH3 domain containing 2
STC2 stanniocalcin 2
SYT1 synaptotagmin I
TLR4 toll-like receptor 4
TMEM14A transmembrane protein 14A
TMEM176B transmembrane protein 176B
UGDH UDP-glucose 6-dehydrogenase
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1

decreased expression

Symbol Name
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACTG2 actin, gamma 2, smooth muscle, enteric
BPHL biphenyl hydrolase-like (serine hydrolase)
CD44 CD44 molecule (Indian blood group)
CD9 CD9 molecule
COCH cochlin
CST1 cystatin SN
CXCL8 chemokine (C-X-C motif) ligand 8
DHRS2 dehydrogenase/reductase (SDR family) member 2
DUSP6 dual specificity phosphatase 6
EDNRA endothelin receptor type A
EIF5A eukaryotic translation initiation factor 5A
F2R coagulation factor II (thrombin) receptor
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAR2 fatty acyl CoA reductase 2
GATA2 GATA binding protein 2
GLS glutaminase
GSTM3 glutathione S-transferase mu 3 (brain)
IER3 immediate early response 3
IQGAP2 IQ motif containing GTPase activating protein 2
KANK2 KN motif and ankyrin repeat domains 2
KIAA0226L KIAA0226-like
METRN meteorin, glial cell differentiation regulator
MN1 meningioma (disrupted in balanced translocation) 1
MYH11 myosin, heavy chain 11, smooth muscle
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PRKD3 protein kinase D3
QPCT glutaminyl-peptide cyclotransferase
RAMP1 receptor (G protein-coupled) activity modifying protein 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SNN stannin
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
SYNM synemin, intermediate filament protein
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TGFBR3 transforming growth factor, beta receptor III
THBD thrombomodulin
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TPM4 tropomyosin 4
VGLL4 vestigial-like family member 4
ZCCHC24 zinc finger, CCHC domain containing 24