BRD-A19500257_geldanamycin_A549_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

362 genes differentially expressed following the BRD-A19500257_geldanamycin_A549_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACBD3 acyl-CoA binding domain containing 3
ACKR3 atypical chemokine receptor 3
ADAMDEC1 ADAM-like, decysin 1
AFF1 AF4/FMR2 family, member 1
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ANOS1 anosmin 1
ANPEP alanyl (membrane) aminopeptidase
APOB apolipoprotein B
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BAG6 BCL2-associated athanogene 6
BBX bobby sox homolog (Drosophila)
BEX1 brain expressed, X-linked 1
BRD8 bromodomain containing 8
C1ORF54 chromosome 1 open reading frame 54
C6ORF48 chromosome 6 open reading frame 48
CAST calpastatin
CAT catalase
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCNG1 cyclin G1
CCNG2 cyclin G2
CD163 CD163 molecule
CD24 CD24 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK19 cyclin-dependent kinase 19
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CES1 carboxylesterase 1
CES2 carboxylesterase 2
CGA glycoprotein hormones, alpha polypeptide
CHGB chromogranin B
CLU clusterin
COL4A5 collagen, type IV, alpha 5
CPB1 carboxypeptidase B1 (tissue)
CRABP1 cellular retinoic acid binding protein 1
CRABP2 cellular retinoic acid binding protein 2
CREM cAMP responsive element modulator
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CRYAB crystallin, alpha B
CSNK2B casein kinase 2, beta polypeptide
CSRP2 cysteine and glycine-rich protein 2
CXADR coxsackie virus and adenovirus receptor
CXCL13 chemokine (C-X-C motif) ligand 13
CYFIP2 cytoplasmic FMR1 interacting protein 2
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DAPK1 death-associated protein kinase 1
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DENND2D DENN/MADD domain containing 2D
DEPTOR DEP domain containing MTOR-interacting protein
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DSP desmoplakin
DUSP14 dual specificity phosphatase 14
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EGFL6 EGF-like-domain, multiple 6
EGFR epidermal growth factor receptor
EIF4B eukaryotic translation initiation factor 4B
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPB41L3 erythrocyte membrane protein band 4.1-like 3
EPCAM epithelial cell adhesion molecule
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERBB2 erb-b2 receptor tyrosine kinase 2
EXT1 exostosin glycosyltransferase 1
FAM117A family with sequence similarity 117, member A
FAM134B family with sequence similarity 134, member B
FBLN1 fibulin 1
FNBP1 formin binding protein 1
FOSL2 FOS-like antigen 2
FOXO4 forkhead box O4
FTH1 ferritin, heavy polypeptide 1
FXR1 fragile X mental retardation, autosomal homolog 1
FZD7 frizzled class receptor 7
GABARAPL1 GABA(A) receptor-associated protein like 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45B growth arrest and DNA-damage-inducible, beta
GCLM glutamate-cysteine ligase, modifier subunit
GLUL glutamate-ammonia ligase
GOLGB1 golgin B1
GPATCH8 G patch domain containing 8
GPX3 glutathione peroxidase 3
GSTA1 glutathione S-transferase alpha 1
HBD hemoglobin, delta
HBP1 HMG-box transcription factor 1
HEBP1 heme binding protein 1
HEPH hephaestin
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
HSPA4 heat shock 70kDa protein 4
HSPE1 heat shock 10kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
IGBP1 immunoglobulin (CD79A) binding protein 1
IGF1R insulin-like growth factor 1 receptor
JUP junction plakoglobin
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIF5C kinesin family member 5C
KIZ kizuna centrosomal protein
KLHDC10 kelch domain containing 10
KLHL24 kelch-like family member 24
KRT13 keratin 13, type I
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT17 keratin 17, type I
KRT19 keratin 19, type I
KRT5 keratin 5, type II
KRT8 keratin 8, type II
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial)
LBH limb bud and heart development
LTA4H leukotriene A4 hydrolase
LXN latexin
MAN2A1 mannosidase, alpha, class 2A, member 1
MAOA monoamine oxidase A
MAP7 microtubule-associated protein 7
MAST2 microtubule associated serine/threonine kinase 2
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MERTK MER proto-oncogene, tyrosine kinase
MFAP5 microfibrillar associated protein 5
MME membrane metallo-endopeptidase
MSMB microseminoprotein, beta-
MYB v-myb avian myeloblastosis viral oncogene homolog
MYH10 myosin, heavy chain 10, non-muscle
MYO6 myosin VI
NDRG1 N-myc downstream regulated 1
NEFH neurofilament, heavy polypeptide
NFIL3 nuclear factor, interleukin 3 regulated
NID2 nidogen 2 (osteonidogen)
NR1D2 nuclear receptor subfamily 1, group D, member 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRIP1 nuclear receptor interacting protein 1
NUMA1 nuclear mitotic apparatus protein 1
NXN nucleoredoxin
OSBPL9 oxysterol binding protein-like 9
P3H2 prolyl 3-hydroxylase 2
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PBLD phenazine biosynthesis-like protein domain containing
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDLIM5 PDZ and LIM domain 5
PDZK1 PDZ domain containing 1
PERP PERP, TP53 apoptosis effector
PGAP1 post-GPI attachment to proteins 1
PLBD1 phospholipase B domain containing 1
PLD3 phospholipase D family, member 3
PLTP phospholipid transfer protein
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PPL periplakin
PROM1 prominin 1
PRRC1 proline-rich coiled-coil 1
PRUNE prune exopolyphosphatase
QPRT quinolinate phosphoribosyltransferase
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBKS ribokinase
RND3 Rho family GTPase 3
RPL22 ribosomal protein L22
RPL31 ribosomal protein L31
RRBP1 ribosome binding protein 1
RSL1D1 ribosomal L1 domain containing 1
S100A10 S100 calcium binding protein A10
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SCPEP1 serine carboxypeptidase 1
SEC31A SEC31 homolog A (S. cerevisiae)
SEPP1 selenoprotein P, plasma, 1
SESN1 sestrin 1
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SI sucrase-isomaltase (alpha-glucosidase)
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SLPI secretory leukocyte peptidase inhibitor
SNAP25 synaptosomal-associated protein, 25kDa
SOD2 superoxide dismutase 2, mitochondrial
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STC2 stanniocalcin 2
STK26 serine/threonine protein kinase 26
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SV2C synaptic vesicle glycoprotein 2C
TBC1D4 TBC1 domain family, member 4
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TBX3 T-box 3
TFF1 trefoil factor 1
TGFBR3 transforming growth factor, beta receptor III
TSPAN13 tetraspanin 13
TSPYL5 TSPY-like 5
TXNIP thioredoxin interacting protein
UBB ubiquitin B
WIF1 WNT inhibitory factor 1
ZBTB38 zinc finger and BTB domain containing 38
ZKSCAN1 zinc finger with KRAB and SCAN domains 1
ZSWIM8 zinc finger, SWIM-type containing 8

decreased expression

Symbol Name
AHNAK2 AHNAK nucleoprotein 2
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMDHD2 amidohydrolase domain containing 2
ANK2 ankyrin 2, neuronal
ANKRD10 ankyrin repeat domain 10
ANXA1 annexin A1
AREG amphiregulin
ASRGL1 asparaginase like 1
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
BAMBI BMP and activin membrane-bound inhibitor
BHLHE40 basic helix-loop-helix family, member e40
BRCA1 breast cancer 1, early onset
C1R complement component 1, r subcomponent
C3 complement component 3
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCDC109B coiled-coil domain containing 109B
CCDC85B coiled-coil domain containing 85B
CCNE2 cyclin E2
CD47 CD47 molecule
CD69 CD69 molecule
CDC7 cell division cycle 7
CDCA4 cell division cycle associated 4
CDK2 cyclin-dependent kinase 2
CENPU centromere protein U
CHL1 cell adhesion molecule L1-like
CHRDL1 chordin-like 1
CKLF chemokine-like factor
COPS7A COP9 signalosome subunit 7A
CRIP1 cysteine-rich protein 1 (intestinal)
CRIP2 cysteine-rich protein 2
CSTA cystatin A (stefin A)
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
DGKZ diacylglycerol kinase, zeta
DHFR dihydrofolate reductase
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLX2 distal-less homeobox 2
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EIF5A eukaryotic translation initiation factor 5A
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENO1 enolase 1, (alpha)
EPHA2 EPH receptor A2
EPHB2 EPH receptor B2
ETV1 ets variant 1
EXOSC4 exosome component 4
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP7 fatty acid binding protein 7, brain
FEN1 flap structure-specific endonuclease 1
FHL1 four and a half LIM domains 1
FOSL1 FOS-like antigen 1
FOXG1 forkhead box G1
FSD1 fibronectin type III and SPRY domain containing 1
G0S2 G0/G1 switch 2
GINS2 GINS complex subunit 2 (Psf2 homolog)
GNAS GNAS complex locus
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GRIA2 glutamate receptor, ionotropic, AMPA 2
HIST1H2BG histone cluster 1, H2bg
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
ITGA6 integrin, alpha 6
ITGB1BP1 integrin beta 1 binding protein 1
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JUN jun proto-oncogene
KAT2B K(lysine) acetyltransferase 2B
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
L1CAM L1 cell adhesion molecule
LMO4 LIM domain only 4
LOC100505650 uncharacterized LOC100505650
MCL1 myeloid cell leukemia 1
MCM10 minichromosome maintenance complex component 10
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MELK maternal embryonic leucine zipper kinase
METRN meteorin, glial cell differentiation regulator
MGLL monoglyceride lipase
MMD monocyte to macrophage differentiation-associated
MX1 MX dynamin-like GTPase 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCALD neurocalcin delta
NFIB nuclear factor I/B
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRGN neurogranin (protein kinase C substrate, RC3)
NT5E 5'-nucleotidase, ecto (CD73)
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCSK1 proprotein convertase subtilisin/kexin type 1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PFKP phosphofructokinase, platelet
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PHTF2 putative homeodomain transcription factor 2
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLN phospholamban
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRKCA protein kinase C, alpha
PRSS3 protease, serine, 3
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PXMP2 peroxisomal membrane protein 2, 22kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RGS1 regulator of G-protein signaling 1
RGS4 regulator of G-protein signaling 4
RHOB ras homolog family member B
RNASEH2A ribonuclease H2, subunit A
RRM2 ribonucleotide reductase M2
SATB2 SATB homeobox 2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SMAD1 SMAD family member 1
SOBP sine oculis binding protein homolog (Drosophila)
SOX9 SRY (sex determining region Y)-box 9
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SQRDL sulfide quinone reductase-like (yeast)
STEAP1 six transmembrane epithelial antigen of the prostate 1
STK17A serine/threonine kinase 17a
STX1A syntaxin 1A (brain)
SULF1 sulfatase 1
TACC1 transforming, acidic coiled-coil containing protein 1
TFF3 trefoil factor 3 (intestinal)
TFPI2 tissue factor pathway inhibitor 2
TGFBI transforming growth factor, beta-induced, 68kDa
THBS2 thrombospondin 2
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TK1 thymidine kinase 1, soluble
TNC tenascin C
TRIB2 tribbles pseudokinase 2
TRIB3 tribbles pseudokinase 3
TUBB2A tubulin, beta 2A class IIa
TUBB6 tubulin, beta 6 class V
TUBG1 tubulin, gamma 1
UBE2E3 ubiquitin-conjugating enzyme E2E 3
VSNL1 visinin-like 1
WARS tryptophanyl-tRNA synthetase
WSB2 WD repeat and SOCS box containing 2
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
ZBTB18 zinc finger and BTB domain containing 18