BRD-A19500257_geldanamycin_A549_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

240 genes differentially expressed following the BRD-A19500257_geldanamycin_A549_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACBD3 acyl-CoA binding domain containing 3
AGR2 anterior gradient 2
AKAP9 A kinase (PRKA) anchor protein 9
ALOX15B arachidonate 15-lipoxygenase, type B
ARFIP2 ADP-ribosylation factor interacting protein 2
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1
AURKA aurora kinase A
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BMP2 bone morphogenetic protein 2
BRD4 bromodomain containing 4
C1QA complement component 1, q subcomponent, A chain
C6ORF48 chromosome 6 open reading frame 48
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAT catalase
CCL5 chemokine (C-C motif) ligand 5
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCNG1 cyclin G1
CD44 CD44 molecule (Indian blood group)
CES1 carboxylesterase 1
CGA glycoprotein hormones, alpha polypeptide
CHI3L2 chitinase 3-like 2
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
COPA coatomer protein complex, subunit alpha
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRABP1 cellular retinoic acid binding protein 1
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CRYAB crystallin, alpha B
CXCL13 chemokine (C-X-C motif) ligand 13
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
DSC2 desmocollin 2
DSP desmoplakin
DUSP14 dual specificity phosphatase 14
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFHD1 EF-hand domain family, member D1
EGFR epidermal growth factor receptor
EIF4B eukaryotic translation initiation factor 4B
ELF5 E74-like factor 5 (ets domain transcription factor)
ELOVL5 ELOVL fatty acid elongase 5
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPHX2 epoxide hydrolase 2, cytoplasmic
EPS8L2 EPS8-like 2
ERBB2 erb-b2 receptor tyrosine kinase 2
FAM117A family with sequence similarity 117, member A
FBLN1 fibulin 1
FOSL2 FOS-like antigen 2
FOXF2 forkhead box F2
FXR1 fragile X mental retardation, autosomal homolog 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45B growth arrest and DNA-damage-inducible, beta
GCLC glutamate-cysteine ligase, catalytic subunit
GLUL glutamate-ammonia ligase
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
GOLGB1 golgin B1
GOLPH3L golgi phosphoprotein 3-like
GPR88 G protein-coupled receptor 88
GPX3 glutathione peroxidase 3
GSTA1 glutathione S-transferase alpha 1
HMOX1 heme oxygenase 1
HOXA5 homeobox A5
HOXC10 homeobox C10
HSPA8 heat shock 70kDa protein 8
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
KRT14 keratin 14, type I
KRT16 keratin 16, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
LAMB3 laminin, beta 3
LBH limb bud and heart development
LDHB lactate dehydrogenase B
LRRC8D leucine rich repeat containing 8 family, member D
LTBP1 latent transforming growth factor beta binding protein 1
MAOA monoamine oxidase A
MFAP5 microfibrillar associated protein 5
MME membrane metallo-endopeptidase
MSMB microseminoprotein, beta-
N4BP2L1 NEDD4 binding protein 2-like 1
NAV2 neuron navigator 2
NDRG1 N-myc downstream regulated 1
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEFH neurofilament, heavy polypeptide
NFIL3 nuclear factor, interleukin 3 regulated
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NXN nucleoredoxin
P3H2 prolyl 3-hydroxylase 2
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDIA5 protein disulfide isomerase family A, member 5
PENK proenkephalin
PLTP phospholipid transfer protein
PRR5 proline rich 5 (renal)
PTP4A1 protein tyrosine phosphatase type IVA, member 1
QPRT quinolinate phosphoribosyltransferase
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RASIP1 Ras interacting protein 1
RBKS ribokinase
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RGN regucalcin
RORA RAR-related orphan receptor A
RPL31 ribosomal protein L31
S100A10 S100 calcium binding protein A10
SCPEP1 serine carboxypeptidase 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SPP1 secreted phosphoprotein 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STC2 stanniocalcin 2
STK26 serine/threonine protein kinase 26
STOM stomatin
TARP TCR gamma alternate reading frame protein
TIMP3 TIMP metallopeptidase inhibitor 3
TP53 tumor protein p53
TSKU tsukushi, small leucine rich proteoglycan
TSPAN13 tetraspanin 13
TUSC3 tumor suppressor candidate 3
UBR2 ubiquitin protein ligase E3 component n-recognin 2
VAV3 vav 3 guanine nucleotide exchange factor
XCL1 chemokine (C motif) ligand 1

decreased expression

Symbol Name
AIM1 absent in melanoma 1
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA1 annexin A1
ASRGL1 asparaginase like 1
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
BAMBI BMP and activin membrane-bound inhibitor
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BHLHE40 basic helix-loop-helix family, member e40
BRCA1 breast cancer 1, early onset
C3ORF14 chromosome 3 open reading frame 14
CASP4 caspase 4, apoptosis-related cysteine peptidase
CCDC109B coiled-coil domain containing 109B
CCDC85B coiled-coil domain containing 85B
CCNB2 cyclin B2
CCNE2 cyclin E2
CD200 CD200 molecule
CD47 CD47 molecule
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDK2 cyclin-dependent kinase 2
CENPU centromere protein U
CHL1 cell adhesion molecule L1-like
COPS7A COP9 signalosome subunit 7A
CRIP2 cysteine-rich protein 2
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CXCL12 chemokine (C-X-C motif) ligand 12
CYCS cytochrome c, somatic
DCTPP1 dCTP pyrophosphatase 1
DHFR dihydrofolate reductase
DHRS2 dehydrogenase/reductase (SDR family) member 2
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EGR3 early growth response 3
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EPHA2 EPH receptor A2
EPHB2 EPH receptor B2
ETV1 ets variant 1
ETV5 ets variant 5
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP7 fatty acid binding protein 7, brain
FEN1 flap structure-specific endonuclease 1
FHL1 four and a half LIM domains 1
FOSL1 FOS-like antigen 1
GGCT gamma-glutamylcyclotransferase
GINS2 GINS complex subunit 2 (Psf2 homolog)
GRIA2 glutamate receptor, ionotropic, AMPA 2
HBEGF heparin-binding EGF-like growth factor
HPCAL1 hippocalcin-like 1
IER3 immediate early response 3
IFI16 interferon, gamma-inducible protein 16
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM2 interferon induced transmembrane protein 2
IGFBP5 insulin-like growth factor binding protein 5
ISG15 ISG15 ubiquitin-like modifier
ITGB1BP1 integrin beta 1 binding protein 1
LOC100505650 uncharacterized LOC100505650
MAL mal, T-cell differentiation protein
MARCKSL1 MARCKS-like 1
METRN meteorin, glial cell differentiation regulator
MMD monocyte to macrophage differentiation-associated
MSLN mesothelin
MX1 MX dynamin-like GTPase 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NCF2 neutrophil cytosolic factor 2
NPTX2 neuronal pentraxin II
NRGN neurogranin (protein kinase C substrate, RC3)
NT5E 5'-nucleotidase, ecto (CD73)
PCSK1 proprotein convertase subtilisin/kexin type 1
PDGFD platelet derived growth factor D
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDLIM3 PDZ and LIM domain 3
PEA15 phosphoprotein enriched in astrocytes 15
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PHTF2 putative homeodomain transcription factor 2
PLAT plasminogen activator, tissue
PLSCR1 phospholipid scramblase 1
PNMA1 paraneoplastic Ma antigen 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRKCA protein kinase C, alpha
PRSS3 protease, serine, 3
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PXMP2 peroxisomal membrane protein 2, 22kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RRM2 ribonucleotide reductase M2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SHCBP1 SHC SH2-domain binding protein 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SPRY2 sprouty homolog 2 (Drosophila)
SQRDL sulfide quinone reductase-like (yeast)
SSBP2 single-stranded DNA binding protein 2
STX1A syntaxin 1A (brain)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
THBS2 thrombospondin 2
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TIPIN TIMELESS interacting protein
TK1 thymidine kinase 1, soluble
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM5 transmembrane protein 5
UPP1 uridine phosphorylase 1
WSB2 WD repeat and SOCS box containing 2
WT1 Wilms tumor 1