BRD-A19500257_geldanamycin_A549_24_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

83 genes differentially expressed following the BRD-A19500257_geldanamycin_A549_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
AGTR1 angiotensin II receptor, type 1
ANGPT1 angiopoietin 1
BCL3 B-cell CLL/lymphoma 3
BIRC3 baculoviral IAP repeat containing 3
CCL5 chemokine (C-C motif) ligand 5
CLU clusterin
COCH cochlin
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CTSK cathepsin K
CXCL10 chemokine (C-X-C motif) ligand 10
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
EGFL6 EGF-like-domain, multiple 6
FXR1 fragile X mental retardation, autosomal homolog 1
GAA glucosidase, alpha; acid
GAGE3 G antigen 3
GALC galactosylceramidase
GATA3 GATA binding protein 3
GPR171 G protein-coupled receptor 171
HIST1H2BD histone cluster 1, H2bd
IFI27 interferon, alpha-inducible protein 27
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IL2RA interleukin 2 receptor, alpha
IL2RB interleukin 2 receptor, beta
IL32 interleukin 32
KIAA0125 KIAA0125
KRT17 keratin 17, type I
KRT23 keratin 23, type I
LDHB lactate dehydrogenase B
LRRN3 leucine rich repeat neuronal 3
MAGEA3 melanoma antigen family A3
MAGEA4 melanoma antigen family A4
MAGEA6 melanoma antigen family A6
NEFH neurofilament, heavy polypeptide
NELL2 NEL-like 2 (chicken)
NLRP2 NLR family, pyrin domain containing 2
OPTN optineurin
PGF placental growth factor
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RCAN2 regulator of calcineurin 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RUNX3 runt-related transcription factor 3
S100A7 S100 calcium binding protein A7
SATB1 SATB homeobox 1
SIDT2 SID1 transmembrane family, member 2
SNAP25 synaptosomal-associated protein, 25kDa
SYNGR3 synaptogyrin 3
TM4SF4 transmembrane 4 L six family member 4
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TSPYL5 TSPY-like 5
XCL1 chemokine (C motif) ligand 1
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble

decreased expression

Symbol Name
AMIGO2 adhesion molecule with Ig-like domain 2
ASCL1 achaete-scute family bHLH transcription factor 1
CALR calreticulin
CDC25B cell division cycle 25B
CSTA cystatin A (stefin A)
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP6 dual specificity phosphatase 6
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EMP1 epithelial membrane protein 1
EREG epiregulin
ETV1 ets variant 1
FOSL1 FOS-like antigen 1
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
IER3 immediate early response 3
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
LCN2 lipocalin 2
NRP1 neuropilin 1
ODC1 ornithine decarboxylase 1
SCG5 secretogranin V
SCGB2A1 secretoglobin, family 2A, member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
TACSTD2 tumor-associated calcium signal transducer 2
TFF1 trefoil factor 1
TIAM1 T-cell lymphoma invasion and metastasis 1
TSPAN8 tetraspanin 8
WNT5A wingless-type MMTV integration site family, member 5A
ZDHHC6 zinc finger, DHHC-type containing 6
Funding