BRD-A19500257_geldanamycin_A375_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

370 genes differentially expressed following the BRD-A19500257_geldanamycin_A375_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ACSF2 acyl-CoA synthetase family member 2
ADCK3 aarF domain containing kinase 3
AKR1C1 aldo-keto reductase family 1, member C1
ARID5B AT rich interactive domain 5B (MRF1-like)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATG14 autophagy related 14
BAG2 BCL2-associated athanogene 2
BAG3 BCL2-associated athanogene 3
BAX BCL2-associated X protein
BRD2 bromodomain containing 2
BSDC1 BSD domain containing 1
BST2 bone marrow stromal cell antigen 2
BTG2 BTG family, member 2
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCDC28A coiled-coil domain containing 28A
CCND2 cyclin D2
CCNG1 cyclin G1
CDK7 cyclin-dependent kinase 7
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CES2 carboxylesterase 2
CFB complement factor B
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COBLL1 cordon-bleu WH2 repeat protein-like 1
CRYAB crystallin, alpha B
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DAPK1 death-associated protein kinase 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT3 DNA-damage-inducible transcript 3
DHRS7 dehydrogenase/reductase (SDR family) member 7
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF4B eukaryotic translation initiation factor 4B
FAM117A family with sequence similarity 117, member A
FAS Fas cell surface death receptor
FDXR ferredoxin reductase
FNBP1 formin binding protein 1
FOLR1 folate receptor 1 (adult)
FOSL2 FOS-like antigen 2
FTH1 ferritin, heavy polypeptide 1
FXR1 fragile X mental retardation, autosomal homolog 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GAS6 growth arrest-specific 6
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
GNS glucosamine (N-acetyl)-6-sulfatase
GOLGA8B golgin A8 family, member B
GPNMB glycoprotein (transmembrane) nmb
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HOXB2 homeobox B2
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA4L heat shock 70kDa protein 4-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
IFITM1 interferon induced transmembrane protein 1
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
ISCU iron-sulfur cluster assembly enzyme
JAM3 junctional adhesion molecule 3
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KIZ kizuna centrosomal protein
LETMD1 LETM1 domain containing 1
LOXL1 lysyl oxidase-like 1
LRPPRC leucine-rich pentatricopeptide repeat containing
MAOA monoamine oxidase A
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MFAP5 microfibrillar associated protein 5
MTSS1 metastasis suppressor 1
MXI1 MAX interactor 1, dimerization protein
NDRG1 N-myc downstream regulated 1
NEFH neurofilament, heavy polypeptide
NEU1 sialidase 1 (lysosomal sialidase)
NUPR1 nuclear protein, transcriptional regulator, 1
NXN nucleoredoxin
OSBPL2 oxysterol binding protein-like 2
OSBPL9 oxysterol binding protein-like 9
P3H2 prolyl 3-hydroxylase 2
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDIA3 protein disulfide isomerase family A, member 3
PEG3 paternally expressed 3
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PLTP phospholipid transfer protein
PLXNB2 plexin B2
POLR1D polymerase (RNA) I polypeptide D, 16kDa
QPRT quinolinate phosphoribosyltransferase
RABGAP1L RAB GTPase activating protein 1-like
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RND3 Rho family GTPase 3
RORA RAR-related orphan receptor A
RPL28 ribosomal protein L28
RPL31 ribosomal protein L31
RPS27L ribosomal protein S27-like
S100A8 S100 calcium binding protein A8
SCUBE2 signal peptide, CUB domain, EGF-like 2
SEPP1 selenoprotein P, plasma, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SESN1 sestrin 1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SNX6 sorting nexin 6
SOX4 SRY (sex determining region Y)-box 4
SP140L SP140 nuclear body protein-like
SPATA20 spermatogenesis associated 20
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STAR steroidogenic acute regulatory protein
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SUSD4 sushi domain containing 4
TMEM30B transmembrane protein 30B
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNNC1 troponin C type 1 (slow)
TOX thymocyte selection-associated high mobility group box
TOX3 TOX high mobility group box family member 3
TRIM22 tripartite motif containing 22
TTC39A tetratricopeptide repeat domain 39A
TUSC3 tumor suppressor candidate 3
USP3 ubiquitin specific peptidase 3
WSB1 WD repeat and SOCS box containing 1
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)
ZMAT3 zinc finger, matrin-type 3
ZNF331 zinc finger protein 331
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACP6 acid phosphatase 6, lysophosphatidic
ADAM19 ADAM metallopeptidase domain 19
ADRB2 adrenoceptor beta 2, surface
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMDHD2 amidohydrolase domain containing 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANO1 anoctamin 1, calcium activated chloride channel
APOLD1 apolipoprotein L domain containing 1
AREG amphiregulin
ASF1B anti-silencing function 1B histone chaperone
ASPH aspartate beta-hydroxylase
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
ATXN1 ataxin 1
AURKB aurora kinase B
BCAR3 breast cancer anti-estrogen resistance 3
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
C1ORF106 chromosome 1 open reading frame 106
C1QTNF3 C1q and tumor necrosis factor related protein 3
CALD1 caldesmon 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CBFB core-binding factor, beta subunit
CCDC85B coiled-coil domain containing 85B
CCNA2 cyclin A2
CCND1 cyclin D1
CCNE2 cyclin E2
CCNF cyclin F
CD24 CD24 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDCA4 cell division cycle associated 4
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDH19 cadherin 19, type 2
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHSY1 chondroitin sulfate synthase 1
CKLF chemokine-like factor
CMTM6 CKLF-like MARVEL transmembrane domain containing 6
COL13A1 collagen, type XIII, alpha 1
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
COL9A3 collagen, type IX, alpha 3
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CST1 cystatin SN
CST6 cystatin E/M
CTGF connective tissue growth factor
CXCL14 chemokine (C-X-C motif) ligand 14
CYR61 cysteine-rich, angiogenic inducer, 61
DCBLD2 discoidin, CUB and LCCL domain containing 2
DCK deoxycytidine kinase
DKK1 dickkopf WNT signaling pathway inhibitor 1
DOCK4 dedicator of cytokinesis 4
DPY19L1 dpy-19-like 1 (C. elegans)
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
DYNLT3 dynein, light chain, Tctex-type 3
EDNRB endothelin receptor type B
EFNB2 ephrin-B2
EGR3 early growth response 3
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMP1 epithelial membrane protein 1
ENO1 enolase 1, (alpha)
EPHA2 EPH receptor A2
EREG epiregulin
ETV1 ets variant 1
ETV5 ets variant 5
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FADD Fas (TNFRSF6)-associated via death domain
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
FZD7 frizzled class receptor 7
GAS7 growth arrest-specific 7
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GRIA2 glutamate receptor, ionotropic, AMPA 2
H2AFX H2A histone family, member X
HES1 hes family bHLH transcription factor 1
HHEX hematopoietically expressed homeobox
HJURP Holliday junction recognition protein
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMGA1 high mobility group AT-hook 1
HMGA2 high mobility group AT-hook 2
HOPX HOP homeobox
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP3 insulin-like growth factor binding protein 3
IGFBP4 insulin-like growth factor binding protein 4
IGFBP7 insulin-like growth factor binding protein 7
IL13RA2 interleukin 13 receptor, alpha 2
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
INHBA inhibin, beta A
ITGA6 integrin, alpha 6
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
JADE2 jade family PHD finger 2
JAG1 jagged 1
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KIF14 kinesin family member 14
KIF18B kinesin family member 18B
LAMB1 laminin, beta 1
LEF1 lymphoid enhancer-binding factor 1
LIF leukemia inhibitory factor
LMCD1 LIM and cysteine-rich domains 1
LMNB1 lamin B1
LMO2 LIM domain only 2 (rhombotin-like 1)
MAP7 microtubule-associated protein 7
MARCKSL1 MARCKS-like 1
MCM10 minichromosome maintenance complex component 10
MCM4 minichromosome maintenance complex component 4
MEGF9 multiple EGF-like-domains 9
MELK maternal embryonic leucine zipper kinase
MGLL monoglyceride lipase
MGP matrix Gla protein
MKI67 marker of proliferation Ki-67
MMD monocyte to macrophage differentiation-associated
MSN moesin
MTCL1 microtubule crosslinking factor 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NAV3 neuron navigator 3
NBN nibrin
NCAPG non-SMC condensin I complex, subunit G
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NES nestin
NET1 neuroepithelial cell transforming 1
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NQO1 NAD(P)H dehydrogenase, quinone 1
NRGN neurogranin (protein kinase C substrate, RC3)
NRN1 neuritin 1
NRP1 neuropilin 1
NT5E 5'-nucleotidase, ecto (CD73)
NTM neurotrimin
NUSAP1 nucleolar and spindle associated protein 1
OSBPL10 oxysterol binding protein-like 10
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PCSK1 proprotein convertase subtilisin/kexin type 1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PLK1 polo-like kinase 1
PMEPA1 prostate transmembrane protein, androgen induced 1
PMP22 peripheral myelin protein 22
POSTN periostin, osteoblast specific factor
PPAP2C phosphatidic acid phosphatase type 2C
PPARG peroxisome proliferator-activated receptor gamma
PRKD3 protein kinase D3
PSIP1 PC4 and SFRS1 interacting protein 1
PTPN12 protein tyrosine phosphatase, non-receptor type 12
QPCT glutaminyl-peptide cyclotransferase
RAB31 RAB31, member RAS oncogene family
RBMS1 RNA binding motif, single stranded interacting protein 1
RMI1 RecQ mediated genome instability 1
RNASEH2A ribonuclease H2, subunit A
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RRM2 ribonucleotide reductase M2
S100B S100 calcium binding protein B
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SHCBP1 SHC SH2-domain binding protein 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SMOX spermine oxidase
SNAI2 snail family zinc finger 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX9 SRY (sex determining region Y)-box 9
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPARCL1 SPARC-like 1 (hevin)
SPATS2L spermatogenesis associated, serine-rich 2-like
SPC25 SPC25, NDC80 kinetochore complex component
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SRPX sushi-repeat containing protein, X-linked
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STC1 stanniocalcin 1
STK17A serine/threonine kinase 17a
STX1A syntaxin 1A (brain)
SYNM synemin, intermediate filament protein
TACC3 transforming, acidic coiled-coil containing protein 3
TCL1A T-cell leukemia/lymphoma 1A
TGFA transforming growth factor, alpha
TGFBI transforming growth factor, beta-induced, 68kDa
THBD thrombomodulin
THBS1 thrombospondin 1
TIAM1 T-cell lymphoma invasion and metastasis 1
TIMP3 TIMP metallopeptidase inhibitor 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TMEM2 transmembrane protein 2
TMX4 thioredoxin-related transmembrane protein 4
TNC tenascin C
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIB2 tribbles pseudokinase 2
TSPAN4 tetraspanin 4
TSPAN5 tetraspanin 5
UBE2C ubiquitin-conjugating enzyme E2C
UPP1 uridine phosphorylase 1
VCAN versican
VGLL4 vestigial-like family member 4
WWTR1 WW domain containing transcription regulator 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein