BRD-A19500257_geldanamycin_A375_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

126 genes differentially expressed following the BRD-A19500257_geldanamycin_A375_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADCK3 aarF domain containing kinase 3
ADIRF adipogenesis regulatory factor
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
BASP1 brain abundant, membrane attached signal protein 1
BTG2 BTG family, member 2
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNA1 cyclin A1
CCND2 cyclin D2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CELF2 CUGBP, Elav-like family member 2
CFB complement factor B
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CRYAB crystallin, alpha B
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT3 DNA-damage-inducible transcript 3
DHDDS dehydrodolichyl diphosphate synthase
DLK1 delta-like 1 homolog (Drosophila)
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DUSP1 dual specificity phosphatase 1
FAM46A family with sequence similarity 46, member A
FAS Fas cell surface death receptor
FDXR ferredoxin reductase
FOS FBJ murine osteosarcoma viral oncogene homolog
GADD45A growth arrest and DNA-damage-inducible, alpha
GDF15 growth differentiation factor 15
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IFITM1 interferon induced transmembrane protein 1
IFRD1 interferon-related developmental regulator 1
JMJD6 jumonji domain containing 6
KAZN kazrin, periplakin interacting protein
MAMLD1 mastermind-like domain containing 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1M metallothionein 1M
NEFH neurofilament, heavy polypeptide
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUPR1 nuclear protein, transcriptional regulator, 1
P3H2 prolyl 3-hydroxylase 2
PLAGL1 pleiomorphic adenoma gene-like 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RPL27A ribosomal protein L27a
RPS27L ribosomal protein S27-like
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SFN stratifin
SIK1 salt-inducible kinase 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLPI secretory leukocyte peptidase inhibitor
SOX4 SRY (sex determining region Y)-box 4
TNNC1 troponin C type 1 (slow)
TRIM22 tripartite motif containing 22
TRIP6 thyroid hormone receptor interactor 6
TTC39A tetratricopeptide repeat domain 39A
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WISP2 WNT1 inducible signaling pathway protein 2
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AREG amphiregulin
ATXN1 ataxin 1
CCDC85B coiled-coil domain containing 85B
CCND1 cyclin D1
CDCA4 cell division cycle associated 4
CXCL14 chemokine (C-X-C motif) ligand 14
DOCK4 dedicator of cytokinesis 4
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EFNB2 ephrin-B2
EREG epiregulin
ETV1 ets variant 1
ETV5 ets variant 5
FGFR2 fibroblast growth factor receptor 2
FOSL1 FOS-like antigen 1
FXYD2 FXYD domain containing ion transport regulator 2
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
HPCAL1 hippocalcin-like 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL13RA2 interleukin 13 receptor, alpha 2
IL1R1 interleukin 1 receptor, type I
ITGA6 integrin, alpha 6
JAG1 jagged 1
KYNU kynureninase
MGLL monoglyceride lipase
MMD monocyte to macrophage differentiation-associated
NES nestin
NET1 neuroepithelial cell transforming 1
NRGN neurogranin (protein kinase C substrate, RC3)
NRP1 neuropilin 1
NT5E 5'-nucleotidase, ecto (CD73)
NUSAP1 nucleolar and spindle associated protein 1
OSBPL10 oxysterol binding protein-like 10
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAT plasminogen activator, tissue
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PRKD3 protein kinase D3
RIN2 Ras and Rab interactor 2
RRM2 ribonucleotide reductase M2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SPRY4 sprouty homolog 4 (Drosophila)
SYNM synemin, intermediate filament protein
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TLR4 toll-like receptor 4
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TSPAN4 tetraspanin 4
WWTR1 WW domain containing transcription regulator 1