BRD-A19500257_geldanamycin_A375_24_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

272 genes differentially expressed following the BRD-A19500257_geldanamycin_A375_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ALCAM activated leukocyte cell adhesion molecule
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BEX4 brain expressed, X-linked 4
BMP4 bone morphogenetic protein 4
C6ORF48 chromosome 6 open reading frame 48
CA11 carbonic anhydrase XI
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCND2 cyclin D2
CCNG1 cyclin G1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CELF2 CUGBP, Elav-like family member 2
CES2 carboxylesterase 2
CFB complement factor B
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COBLL1 cordon-bleu WH2 repeat protein-like 1
COL4A5 collagen, type IV, alpha 5
COL8A2 collagen, type VIII, alpha 2
COL9A2 collagen, type IX, alpha 2
CRYAB crystallin, alpha B
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL13 chemokine (C-X-C motif) ligand 13
CYFIP2 cytoplasmic FMR1 interacting protein 2
DDB2 damage-specific DNA binding protein 2, 48kDa
DLD dihydrolipoamide dehydrogenase
DLK1 delta-like 1 homolog (Drosophila)
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DSE dermatan sulfate epimerase
DYRK4 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
FADS3 fatty acid desaturase 3
FAM117A family with sequence similarity 117, member A
FAS Fas cell surface death receptor
FBN2 fibrillin 2
FDXR ferredoxin reductase
FTH1 ferritin, heavy polypeptide 1
FXR1 fragile X mental retardation, autosomal homolog 1
GAS6 growth arrest-specific 6
GBP1 guanylate binding protein 1, interferon-inducible
GDF15 growth differentiation factor 15
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSPA4L heat shock 70kDa protein 4-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPA9 heat shock 70kDa protein 9 (mortalin)
HSPH1 heat shock 105kDa/110kDa protein 1
IL32 interleukin 32
KAZN kazrin, periplakin interacting protein
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KIZ kizuna centrosomal protein
KRT13 keratin 13, type I
KRT17 keratin 17, type I
LRPPRC leucine-rich pentatricopeptide repeat containing
LRRC8D leucine rich repeat containing 8 family, member D
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MEST mesoderm specific transcript
NEFH neurofilament, heavy polypeptide
NUPR1 nuclear protein, transcriptional regulator, 1
NXN nucleoredoxin
ODC1 ornithine decarboxylase 1
P3H2 prolyl 3-hydroxylase 2
PCP4 Purkinje cell protein 4
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFC platelet derived growth factor C
PEG3 paternally expressed 3
PFKM phosphofructokinase, muscle
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLAGL1 pleiomorphic adenoma gene-like 1
PLD3 phospholipase D family, member 3
PLXNB2 plexin B2
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
QPRT quinolinate phosphoribosyltransferase
RCN1 reticulocalbin 1, EF-hand calcium binding domain
REPIN1 replication initiator 1
RGS1 regulator of G-protein signaling 1
RGS10 regulator of G-protein signaling 10
RGS2 regulator of G-protein signaling 2
RPL31 ribosomal protein L31
RPS21 ribosomal protein S21
RPS27L ribosomal protein S27-like
S100A8 S100 calcium binding protein A8
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SESN1 sestrin 1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SNCAIP synuclein, alpha interacting protein
SNX6 sorting nexin 6
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
STAR steroidogenic acute regulatory protein
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
TLK2 tousled-like kinase 2
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TNNT1 troponin T type 1 (skeletal, slow)
TOX thymocyte selection-associated high mobility group box
TRIM22 tripartite motif containing 22
USP3 ubiquitin specific peptidase 3
WISP2 WNT1 inducible signaling pathway protein 2
XIST X inactive specific transcript (non-protein coding)
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANO1 anoctamin 1, calcium activated chloride channel
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARHGAP12 Rho GTPase activating protein 12
ASF1B anti-silencing function 1B histone chaperone
ASPH aspartate beta-hydroxylase
ATAD2 ATPase family, AAA domain containing 2
AURKB aurora kinase B
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCAR3 breast cancer anti-estrogen resistance 3
C1QTNF3 C1q and tumor necrosis factor related protein 3
CBFB core-binding factor, beta subunit
CCNA2 cyclin A2
CCND1 cyclin D1
CCNE2 cyclin E2
CD24 CD24 molecule
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDK2 cyclin-dependent kinase 2
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CENPU centromere protein U
CNIH3 cornichon family AMPA receptor auxiliary protein 3
COL4A2 collagen, type IV, alpha 2
COL9A3 collagen, type IX, alpha 3
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCL14 chemokine (C-X-C motif) ligand 14
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCBLD2 discoidin, CUB and LCCL domain containing 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLX2 distal-less homeobox 2
DNM1L dynamin 1-like
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EDNRB endothelin receptor type B
EFNB2 ephrin-B2
EGR3 early growth response 3
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMP1 epithelial membrane protein 1
ENO1 enolase 1, (alpha)
ERBB3 erb-b2 receptor tyrosine kinase 3
EREG epiregulin
ETV1 ets variant 1
ETV5 ets variant 5
EXOSC4 exosome component 4
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FEN1 flap structure-specific endonuclease 1
FGF13 fibroblast growth factor 13
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
FZD7 frizzled class receptor 7
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLRX glutaredoxin (thioltransferase)
GNG11 guanine nucleotide binding protein (G protein), gamma 11
HES1 hes family bHLH transcription factor 1
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMGA2 high mobility group AT-hook 2
HN1 hematological and neurological expressed 1
HOPX HOP homeobox
ICAM3 intercellular adhesion molecule 3
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IGFBP3 insulin-like growth factor binding protein 3
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
INHBA inhibin, beta A
IRS2 insulin receptor substrate 2
ITGA6 integrin, alpha 6
JAG1 jagged 1
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4
KLF6 Kruppel-like factor 6
KYNU kynureninase
LAMB1 laminin, beta 1
LGALS3 lectin, galactoside-binding, soluble, 3
LIF leukemia inhibitory factor
MARCKSL1 MARCKS-like 1
MCL1 myeloid cell leukemia 1
MCM4 minichromosome maintenance complex component 4
MELK maternal embryonic leucine zipper kinase
MGLL monoglyceride lipase
MIA melanoma inhibitory activity
MMD monocyte to macrophage differentiation-associated
NEFL neurofilament, light polypeptide
NES nestin
NET1 neuroepithelial cell transforming 1
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NQO1 NAD(P)H dehydrogenase, quinone 1
NRGN neurogranin (protein kinase C substrate, RC3)
NRN1 neuritin 1
NRP1 neuropilin 1
OSBPL10 oxysterol binding protein-like 10
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLEC plectin
PMEPA1 prostate transmembrane protein, androgen induced 1
PMP22 peripheral myelin protein 22
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POSTN periostin, osteoblast specific factor
PPAP2B phosphatidic acid phosphatase type 2B
PPARG peroxisome proliferator-activated receptor gamma
PPIF peptidylprolyl isomerase F
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRKD3 protein kinase D3
PRSS3 protease, serine, 3
PTPN12 protein tyrosine phosphatase, non-receptor type 12
QPCT glutaminyl-peptide cyclotransferase
RBMS1 RNA binding motif, single stranded interacting protein 1
RCAN1 regulator of calcineurin 1
RFC2 replication factor C (activator 1) 2, 40kDa
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RRM2 ribonucleotide reductase M2
S100A11 S100 calcium binding protein A11
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SKAP2 src kinase associated phosphoprotein 2
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SMAGP small cell adhesion glycoprotein
SNAI2 snail family zinc finger 2
SOX11 SRY (sex determining region Y)-box 11
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPATS2L spermatogenesis associated, serine-rich 2-like
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SRPX sushi-repeat containing protein, X-linked
SRSF1 serine/arginine-rich splicing factor 1
STK17A serine/threonine kinase 17a
STX1A syntaxin 1A (brain)
SYNM synemin, intermediate filament protein
TAGLN2 transgelin 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFPI2 tissue factor pathway inhibitor 2
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIAM1 T-cell lymphoma invasion and metastasis 1
TIMP3 TIMP metallopeptidase inhibitor 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TMBIM6 transmembrane BAX inhibitor motif containing 6
TMEM2 transmembrane protein 2
TNC tenascin C
TRIM9 tripartite motif containing 9
TUBA4A tubulin, alpha 4a
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
USP1 ubiquitin specific peptidase 1
VCAN versican
WSB2 WD repeat and SOCS box containing 2
WWTR1 WW domain containing transcription regulator 1