BRD-A19500257_geldanamycin_A375_24_h_0.12_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

245 genes differentially expressed following the BRD-A19500257_geldanamycin_A375_24_h_0.12_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIRF adipogenesis regulatory factor
AHCY adenosylhomocysteinase
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ASCL1 achaete-scute family bHLH transcription factor 1
ATP5G2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
C6ORF48 chromosome 6 open reading frame 48
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCND2 cyclin D2
CCNG1 cyclin G1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CYFIP2 cytoplasmic FMR1 interacting protein 2
DAPK1 death-associated protein kinase 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DLK1 delta-like 1 homolog (Drosophila)
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF4B eukaryotic translation initiation factor 4B
EPS8L2 EPS8-like 2
ERBB2 erb-b2 receptor tyrosine kinase 2
FAM117A family with sequence similarity 117, member A
FAM134B family with sequence similarity 134, member B
FAM171A1 family with sequence similarity 171, member A1
FAS Fas cell surface death receptor
FDXR ferredoxin reductase
FOXO1 forkhead box O1
FXR1 fragile X mental retardation, autosomal homolog 1
GATA2 GATA binding protein 2
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
GM2A GM2 ganglioside activator
GMPR guanosine monophosphate reductase
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA4L heat shock 70kDa protein 4-like
HSPB1 heat shock 27kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
LETMD1 LETM1 domain containing 1
MATN2 matrilin 2
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MN1 meningioma (disrupted in balanced translocation) 1
MYH10 myosin, heavy chain 10, non-muscle
MYLIP myosin regulatory light chain interacting protein
NEFH neurofilament, heavy polypeptide
NME5 NME/NM23 family member 5
NUPR1 nuclear protein, transcriptional regulator, 1
NXN nucleoredoxin
OSBPL9 oxysterol binding protein-like 9
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDGFC platelet derived growth factor C
PFKM phosphofructokinase, muscle
PLAGL1 pleiomorphic adenoma gene-like 1
PLCB4 phospholipase C, beta 4
PLTP phospholipid transfer protein
PROM1 prominin 1
PTGIS prostaglandin I2 (prostacyclin) synthase
QPRT quinolinate phosphoribosyltransferase
RBP4 retinol binding protein 4, plasma
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RPL28 ribosomal protein L28
RPL31 ribosomal protein L31
RPS27L ribosomal protein S27-like
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SIRT3 sirtuin 3
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLPI secretory leukocyte peptidase inhibitor
SNX6 sorting nexin 6
SOX4 SRY (sex determining region Y)-box 4
STOM stomatin
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TOX thymocyte selection-associated high mobility group box
TP53 tumor protein p53
TRIM22 tripartite motif containing 22
UFM1 ubiquitin-fold modifier 1
WFS1 Wolfram syndrome 1 (wolframin)
YPEL5 yippee-like 5 (Drosophila)
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ADAM19 ADAM metallopeptidase domain 19
AGTR1 angiotensin II receptor, type 1
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
APOLD1 apolipoprotein L domain containing 1
AREG amphiregulin
ARL4C ADP-ribosylation factor-like 4C
ASF1B anti-silencing function 1B histone chaperone
ASPH aspartate beta-hydroxylase
ASPN asporin
ATAD2 ATPase family, AAA domain containing 2
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
ATXN1 ataxin 1
AURKB aurora kinase B
BAMBI BMP and activin membrane-bound inhibitor
BCAR3 breast cancer anti-estrogen resistance 3
C1QTNF3 C1q and tumor necrosis factor related protein 3
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCND1 cyclin D1
CCND3 cyclin D3
CCNE2 cyclin E2
CCNF cyclin F
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDK14 cyclin-dependent kinase 14
CDK2 cyclin-dependent kinase 2
CDKN3 cyclin-dependent kinase inhibitor 3
CEMIP cell migration inducing protein, hyaluronan binding
CENPU centromere protein U
COL13A1 collagen, type XIII, alpha 1
COL4A2 collagen, type IV, alpha 2
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
COL9A3 collagen, type IX, alpha 3
CRIP2 cysteine-rich protein 2
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
DOCK4 dedicator of cytokinesis 4
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EDNRB endothelin receptor type B
EFHD2 EF-hand domain family, member D2
EGR3 early growth response 3
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMP1 epithelial membrane protein 1
EREG epiregulin
ETV1 ets variant 1
ETV5 ets variant 5
EXOSC4 exosome component 4
FABP7 fatty acid binding protein 7, brain
FCMR Fc fragment of IgM receptor
FEN1 flap structure-specific endonuclease 1
FGF13 fibroblast growth factor 13
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
FZD7 frizzled class receptor 7
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GAS7 growth arrest-specific 7
GATA3 GATA binding protein 3
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GRIA2 glutamate receptor, ionotropic, AMPA 2
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HMGA2 high mobility group AT-hook 2
HPCAL1 hippocalcin-like 1
IER2 immediate early response 2
IER3 immediate early response 3
IGFBP3 insulin-like growth factor binding protein 3
IGHM immunoglobulin heavy constant mu
INHBA inhibin, beta A
IRS2 insulin receptor substrate 2
JAG1 jagged 1
KYNU kynureninase
L1CAM L1 cell adhesion molecule
LGALS3 lectin, galactoside-binding, soluble, 3
LIF leukemia inhibitory factor
LMCD1 LIM and cysteine-rich domains 1
LPCAT1 lysophosphatidylcholine acyltransferase 1
LRRC15 leucine rich repeat containing 15
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCL1 myeloid cell leukemia 1
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MEF2C myocyte enhancer factor 2C
MGLL monoglyceride lipase
MGP matrix Gla protein
MLPH melanophilin
MMD monocyte to macrophage differentiation-associated
MMP1 matrix metallopeptidase 1
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NES nestin
NPAS2 neuronal PAS domain protein 2
NRGN neurogranin (protein kinase C substrate, RC3)
NRP1 neuropilin 1
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
OSBPL10 oxysterol binding protein-like 10
PCSK1 proprotein convertase subtilisin/kexin type 1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEA15 phosphoprotein enriched in astrocytes 15
PEG10 paternally expressed 10
PHC2 polyhomeotic homolog 2 (Drosophila)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPARG peroxisome proliferator-activated receptor gamma
PRRX1 paired related homeobox 1
PTPN12 protein tyrosine phosphatase, non-receptor type 12
QPCT glutaminyl-peptide cyclotransferase
RFC2 replication factor C (activator 1) 2, 40kDa
RIN2 Ras and Rab interactor 2
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RRM2 ribonucleotide reductase M2
S100B S100 calcium binding protein B
SCGB2A2 secretoglobin, family 2A, member 2
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERTAD2 SERTA domain containing 2
SH2B3 SH2B adaptor protein 3
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC43A3 solute carrier family 43, member 3
SNAI2 snail family zinc finger 2
SOX9 SRY (sex determining region Y)-box 9
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SRPX sushi-repeat containing protein, X-linked
STK17A serine/threonine kinase 17a
STX1A syntaxin 1A (brain)
SYNM synemin, intermediate filament protein
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TGFA transforming growth factor, alpha
THBS2 thrombospondin 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TK1 thymidine kinase 1, soluble
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM2 transmembrane protein 2
TNC tenascin C
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TRD T cell receptor delta locus
TRIB2 tribbles pseudokinase 2
TRIM9 tripartite motif containing 9
TSPAN8 tetraspanin 8
UPP1 uridine phosphorylase 1
VSNL1 visinin-like 1
WWTR1 WW domain containing transcription regulator 1
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
ZWINT ZW10 interacting kinetochore protein