BRD-A19500257_geldanamycin_A375_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

247 genes differentially expressed following the BRD-A19500257_geldanamycin_A375_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACTA2 actin, alpha 2, smooth muscle, aorta
ADIRF adipogenesis regulatory factor
AHNAK2 AHNAK nucleoprotein 2
AK4 adenylate kinase 4
ARID5B AT rich interactive domain 5B (MRF1-like)
ASS1 argininosuccinate synthase 1
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
BAX BCL2-associated X protein
BTG2 BTG family, member 2
CA12 carbonic anhydrase XII
CCND2 cyclin D2
CCNG1 cyclin G1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLU clusterin
COL4A5 collagen, type IV, alpha 5
CPE carboxypeptidase E
CRYAB crystallin, alpha B
CSTA cystatin A (stefin A)
DCN decorin
DDB2 damage-specific DNA binding protein 2, 48kDa
DENND1B DENN/MADD domain containing 1B
DFNA5 deafness, autosomal dominant 5
DLK1 delta-like 1 homolog (Drosophila)
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7
DSE dermatan sulfate epimerase
ECHDC2 enoyl CoA hydratase domain containing 2
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ESR1 estrogen receptor 1
FAS Fas cell surface death receptor
FDXR ferredoxin reductase
FNBP1 formin binding protein 1
GATA3 GATA binding protein 3
GDF15 growth differentiation factor 15
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GJA1 gap junction protein, alpha 1, 43kDa
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
HACD1 3-hydroxyacyl-CoA dehydratase 1
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BK histone cluster 1, H2bk
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
HSPB8 heat shock 22kDa protein 8
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER5 immediate early response 5
IL32 interleukin 32
KAZN kazrin, periplakin interacting protein
KIZ kizuna centrosomal protein
KRT19 keratin 19, type I
KRT23 keratin 23, type I
MAOA monoamine oxidase A
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
METTL7A methyltransferase like 7A
MFAP5 microfibrillar associated protein 5
MYBPC1 myosin binding protein C, slow type
MYL9 myosin, light chain 9, regulatory
ODC1 ornithine decarboxylase 1
P3H2 prolyl 3-hydroxylase 2
PBX3 pre-B-cell leukemia homeobox 3
PNMA2 paraneoplastic Ma antigen 2
PRUNE2 prune homolog 2 (Drosophila)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGIS prostaglandin I2 (prostacyclin) synthase
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RPS27L ribosomal protein S27-like
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SESN1 sestrin 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC38A1 solute carrier family 38, member 1
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLPI secretory leukocyte peptidase inhibitor
SNX6 sorting nexin 6
SPATA20 spermatogenesis associated 20
TCEA2 transcription elongation factor A (SII), 2
TFRC transferrin receptor
TIGAR TP53 induced glycolysis regulatory phosphatase
TMEM106C transmembrane protein 106C
TOB1 transducer of ERBB2, 1
TP53 tumor protein p53
TRIM22 tripartite motif containing 22
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ADGRF5 adhesion G protein-coupled receptor F5
AKR1C1 aldo-keto reductase family 1, member C1
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANO1 anoctamin 1, calcium activated chloride channel
APOD apolipoprotein D
ASPH aspartate beta-hydroxylase
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BASP1 brain abundant, membrane attached signal protein 1
C1QTNF3 C1q and tumor necrosis factor related protein 3
CADM1 cell adhesion molecule 1
CCL21 chemokine (C-C motif) ligand 21
CCNE2 cyclin E2
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDC6 cell division cycle 6
CDH19 cadherin 19, type 2
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
COL15A1 collagen, type XV, alpha 1
COL18A1 collagen, type XVIII, alpha 1
COL4A2 collagen, type IV, alpha 2
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
COL9A3 collagen, type IX, alpha 3
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCR4 chemokine (C-X-C motif) receptor 4
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DCBLD2 discoidin, CUB and LCCL domain containing 2
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EDNRB endothelin receptor type B
EFNB2 ephrin-B2
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ENO1 enolase 1, (alpha)
ERBB3 erb-b2 receptor tyrosine kinase 3
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
ETV1 ets variant 1
FGF13 fibroblast growth factor 13
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
FXYD3 FXYD domain containing ion transport regulator 3
FZD7 frizzled class receptor 7
GAS7 growth arrest-specific 7
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
GNG11 guanine nucleotide binding protein (G protein), gamma 11
H1F0 H1 histone family, member 0
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HOPX HOP homeobox
IER3 immediate early response 3
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
INHBA inhibin, beta A
ITGA6 integrin, alpha 6
KDM3A lysine (K)-specific demethylase 3A
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KLF4 Kruppel-like factor 4 (gut)
KRT7 keratin 7, type II
L1CAM L1 cell adhesion molecule
LEF1 lymphoid enhancer-binding factor 1
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LIF leukemia inhibitory factor
LPXN leupaxin
LRRC15 leucine rich repeat containing 15
MAP1B microtubule-associated protein 1B
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MGLL monoglyceride lipase
MIA melanoma inhibitory activity
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MT1X metallothionein 1X
NDRG1 N-myc downstream regulated 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NES nestin
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NPTX1 neuronal pentraxin I
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRG1 neuregulin 1
NRN1 neuritin 1
NRP1 neuropilin 1
NTS neurotensin
OSBPL10 oxysterol binding protein-like 10
PDE2A phosphodiesterase 2A, cGMP-stimulated
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLP1 proteolipid protein 1
PMP22 peripheral myelin protein 22
PPARG peroxisome proliferator-activated receptor gamma
PVRL3 poliovirus receptor-related 3
REG3A regenerating islet-derived 3 alpha
S100B S100 calcium binding protein B
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SFRP1 secreted frizzled-related protein 1
SGK1 serum/glucocorticoid regulated kinase 1
SH3BP4 SH3-domain binding protein 4
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SMAD1 SMAD family member 1
SNAP25 synaptosomal-associated protein, 25kDa
SOX11 SRY (sex determining region Y)-box 11
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPARCL1 SPARC-like 1 (hevin)
SPATS2L spermatogenesis associated, serine-rich 2-like
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SPTBN1 spectrin, beta, non-erythrocytic 1
STC1 stanniocalcin 1
STK32B serine/threonine kinase 32B
STX1A syntaxin 1A (brain)
SYNM synemin, intermediate filament protein
TCF7 transcription factor 7 (T-cell specific, HMG-box)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFF3 trefoil factor 3 (intestinal)
TFPI2 tissue factor pathway inhibitor 2
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBD thrombomodulin
TIMP3 TIMP metallopeptidase inhibitor 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM2 transmembrane protein 2
TMSB15A thymosin beta 15a
TNC tenascin C
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TRIB2 tribbles pseudokinase 2
TSC22D1 TSC22 domain family, member 1
TSPAN4 tetraspanin 4
TSPAN8 tetraspanin 8
VSNL1 visinin-like 1
WWTR1 WW domain containing transcription regulator 1
ZFP36L1 ZFP36 ring finger protein-like 1