BRD-A19248578_L5288-1MG_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

107 genes differentially expressed following the BRD-A19248578_L5288-1MG_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
BDKRB2 bradykinin receptor B2
BEX4 brain expressed, X-linked 4
C14ORF132 chromosome 14 open reading frame 132
C2CD2 C2 calcium-dependent domain containing 2
CAPG capping protein (actin filament), gelsolin-like
CCL20 chemokine (C-C motif) ligand 20
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
DYNLT3 dynein, light chain, Tctex-type 3
FOXO4 forkhead box O4
GBP2 guanylate binding protein 2, interferon-inducible
GLRX glutaredoxin (thioltransferase)
GULP1 GULP, engulfment adaptor PTB domain containing 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HIST1H2AC histone cluster 1, H2ac
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IRF9 interferon regulatory factor 9
ITM2C integral membrane protein 2C
MTMR11 myotubularin related protein 11
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
MYO1D myosin ID
NDRG1 N-myc downstream regulated 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PLAU plasminogen activator, urokinase
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RGS2 regulator of G-protein signaling 2
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB2A1 secretoglobin, family 2A, member 1
SELENBP1 selenium binding protein 1
SERINC5 serine incorporator 5
SPINK1 serine peptidase inhibitor, Kazal type 1
STC1 stanniocalcin 1
STON1 stonin 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNIP1 TNFAIP3 interacting protein 1
TPP1 tripeptidyl peptidase I
TSPAN7 tetraspanin 7
VEGFA vascular endothelial growth factor A
VGLL4 vestigial-like family member 4
WDR45 WD repeat domain 45
WLS wntless Wnt ligand secretion mediator
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
ANOS1 anosmin 1
ANXA3 annexin A3
AXL AXL receptor tyrosine kinase
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCNA2 cyclin A2
CCNF cyclin F
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
COPS7A COP9 signalosome subunit 7A
CXCL9 chemokine (C-X-C motif) ligand 9
CYR61 cysteine-rich, angiogenic inducer, 61
DIO2 deiodinase, iodothyronine, type II
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP14 dual specificity phosphatase 14
DUT deoxyuridine triphosphatase
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FEN1 flap structure-specific endonuclease 1
FOLR1 folate receptor 1 (adult)
FOXM1 forkhead box M1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GTSE1 G-2 and S-phase expressed 1
HN1 hematological and neurological expressed 1
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF2C kinesin family member 2C
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NKX3-1 NK3 homeobox 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NOP16 NOP16 nucleolar protein
PBK PDZ binding kinase
PLK1 polo-like kinase 1
PRC1 protein regulator of cytokinesis 1
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
QDPR quinoid dihydropteridine reductase
S100A2 S100 calcium binding protein A2
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SNRPF small nuclear ribonucleoprotein polypeptide F
SPC25 SPC25, NDC80 kinetochore complex component
SRSF3 serine/arginine-rich splicing factor 3
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TMPO thymopoietin
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
ZW10 zw10 kinetochore protein